Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape

Prospective mapping of viral mutations that escape antibodies used to treat COVID-19

(2021) Tyler N. Starr et al.   SCIENCE

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

(2021) Paul-Albert Koenig et al.   SCIENCE

Immunological characteristics govern the transition of COVID-19 to endemicity

(2021) Jennie S. Lavine et al.   SCIENCE

Structural Analysis of Neutralizing Epitopes of the SARS-CoV-2 Spike to Guide Therapy and Vaccine Design Strategies

(2021) Maxwell T. Finkelstein et al.   Viruses-Basel

The antigenic anatomy of SARS-CoV-2 receptor binding domain

(2021) Wanwisa Dejnirattisai et al.   CELL

Extremely potent human monoclonal antibodies from COVID-19 convalescent patients

(2021) Emanuele Andreano et al.   CELL

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

(2021) Wilfredo F. Garcia-Beltran et al.   CELL

Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization

(2021) Zhuoming Liu et al.   Cell Host & Microbe

Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies

(2021) Allison J. Greaney et al.   Cell Host & Microbe

Potent Neutralization of SARS-CoV-2 by Hetero-bivalent Alpaca Nanobodies Targeting the Spike Receptor-Binding Domain

(2021) Huan Ma et al.   JOURNAL OF VIROLOGY

Emergence of a SARS-CoV-2 variant of concern with mutations in spike glycoprotein

(2021) Houriiyah Tegally et al.   NATURE

The coronavirus is here to stay — here’s what that means

(2021) Nicky Phillips   NATURE

Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7

(2021) Pengfei Wang et al.   NATURE

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

(2021) Zijun Wang et al.   NATURE

SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

(2021) Constantinos Kurt Wibmer et al.   NATURE MEDICINE

Rapid Determination of Antibody-Antigen Affinity by Mass Photometry

(2021) Di Wu et al.   Jove-Journal of Visualized Experiments

The Case for S2: The Potential Benefits of the S2 Subunit of the SARS-CoV-2 Spike Protein as an Immunogen in Fighting the COVID-19 Pandemic

(2021) Priyanka Shah et al.   Frontiers in Immunology

Integrative proteomics identifies thousands of distinct, multi-epitope, and high-affinity nanobodies

(2021) Yufei Xiang et al.   Cell Systems

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2

(2021) Matthew McCallum et al.   CELL

High-resolution profiling of pathways of escape for SARS-CoV-2 spike-binding antibodies

(2021) Meghan E. Garrett et al.   CELL

Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice

(2021) Raoul De Gasparo et al.   NATURE

Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice

(2021) Phillip Pymm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection

(2021) Leonidas Stamatatos et al.   SCIENCE

Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection

(2021) Ge Song et al.   Nature Communications

A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies

(2021) Chunyan Wang et al.   Nature Communications

A Structural Landscape of Neutralizing Antibodies Against SARS-CoV-2 Receptor Binding Domain

(2021) Ling Niu et al.   Frontiers in Immunology

Tackling COVID-19 with neutralizing monoclonal antibodies

(2021) Davide Corti et al.   CELL

Increased transmissibility and global spread of SARS-CoV-2 variants of concern as at June 2021

(2021) Finlay Campbell et al.   Eurosurveillance

Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations

(2021) Frauke Muecksch et al.   IMMUNITY

COVID vaccines to reach poorest countries in 2023 — despite recent pledges

(2021) T. V. Padma   NATURE

Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants

(2021) Jianliang Xu et al.   NATURE

Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes

(2021) Dapeng Sun et al.   Nature Communications

The development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates

(2021) Gang Ye et al.   eLife

A resource of high-quality and versatile nanobodies for drug delivery

(2021) Zhuolun Shen et al.   iScience

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

SciPy 1.0: fundamental algorithms for scientific computing in Python

(2020) Pauli Virtanen et al.   NATURE METHODS

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody

(2020) Xiaolong Tian et al.   Emerging Microbes & Infections

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

(2020) Michael Letko et al.   Nature Microbiology

Quantifying protein‐protein interactions by molecular counting with mass photometry

(2020) Fabian Soltermann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

Virological assessment of hospitalized patients with COVID-2019

(2020) Roman Wölfel et al.   NATURE

A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2

(2020) Yan Wu et al.   SCIENCE

Site-specific glycan analysis of the SARS-CoV-2 spike

(2020) Yasunori Watanabe et al.   SCIENCE

Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays

(2020) Katharine H. D. Crawford et al.   Viruses-Basel

Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients

(2020) Chek Meng Poh et al.   Nature Communications

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies

(2020) Daniel Wrapp et al.   CELL

Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding

(2020) Tyler N. Starr et al.   CELL

Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells

(2020) Yunlong Cao et al.   CELL

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

(2020) Bette Korber et al.   CELL

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike

(2020) Jiandong Huo et al.   Cell Host & Microbe

The molecular virology of Coronaviruses

(2020) Ella Hartenian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses

(2020) Fabian Schmidt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

(2020) Lihong Liu et al.   NATURE

Potently neutralizing and protective human antibodies against SARS-CoV-2

(2020) Seth J. Zost et al.   NATURE

Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

(2020) Jiangdong Huo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

(2020) Xiangyang Chi et al.   SCIENCE

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

(2020) Alina Baum et al.   SCIENCE

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

(2020) Thomas F. Rogers et al.   SCIENCE

Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

(2020) Kui K. Chan et al.   SCIENCE

Structure-based design of prefusion-stabilized SARS-CoV-2 spikes

(2020) Ching-Lin Hsieh et al.   SCIENCE

Distinct conformational states of SARS-CoV-2 spike protein

(2020) Yongfei Cai et al.   SCIENCE

Unlocking COVID therapeutic targets: a structure-based rationale against SARS-CoV-2, SARS-CoV and MERS-CoV Spike

(2020) João Trigueiro-Louro et al.   Computational and Structural Biotechnology Journal

Effects of Asthma and Human Rhinovirus A16 on the Expression of the SARS-CoV-2 Entry Factors in Human Airway Epithelium

(2020) Ryan C Murphy et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

synergy - A Python library for calculating, analyzing, and visualizing drug combination synergy

(2020) David J Wooten et al.   BIOINFORMATICS

CoV-AbDab: the Coronavirus Antibody Database

(2020) Matthew I J Raybould et al.   BIOINFORMATICS

Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients

(2020) Yang Li et al.   Cellular & Molecular Immunology

Site-specific N-glycosylation Characterization of Recombinant SARS-CoV-2 Spike Proteins

(2020) Yong Zhang et al.   MOLECULAR & CELLULAR PROTEOMICS

Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

(2020) Donald J. Benton et al.   NATURE

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies

(2020) Christopher O. Barnes et al.   NATURE

Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2

(2020) Colton J. Bracken et al.   Nature Chemical Biology

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges

(2020) Beata Turoňová et al.   SCIENCE

Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

(2020) M. Alejandra Tortorici et al.   SCIENCE

The Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes Revealed by Cryo-EM and Cryo-ET

(2020) Chuang Liu et al.   STRUCTURE

Growth, detection, quantification, and inactivation of SARS-CoV-2

(2020) James Brett Case et al.   VIROLOGY

An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction

(2020) Leo Hanke et al.   Nature Communications

Analysis of the SARS-CoV-2 spike protein glycan shield reveals implications for immune recognition

(2020) Oliver C. Grant et al.   Scientific Reports

Beyond Shielding: The Roles of Glycans in the SARS-CoV-2 Spike Protein

(2020) Lorenzo Casalino et al.   ACS Central Science

Using Integrative Modeling Platform to compute, validate, and archive a model of a protein complex structure

(2020) Daniel J. Saltzberg et al.   PROTEIN SCIENCE

High affinity nanobodies block SARS-CoV-2 spike receptor binding domain interaction with human angiotensin converting enzyme

(2020) Thomas J. Esparza et al.   Scientific Reports

Comparison of Four SARS-CoV-2 Neutralization Assays

(2020) Lydia Riepler et al.   Vaccines

Nanobodies as Versatile Tool for Multiscale Imaging Modalities

(2020) Marco Erreni et al.   Biomolecules

Nanobodies, the potent agents to detect and treat the Coronavirus infections: A systematic review

(2020) Hamed Zare et al.   MOLECULAR AND CELLULAR PROBES

Native Mass Spectrometry-Based Screening for Optimal Sample Preparation in Single-Particle Cryo-EM

(2020) Paul Dominic B. Olinares et al.   STRUCTURE

Quantifying Drug Combination Synergy along Potency and Efficacy Axes

(2019) Christian T. Meyer et al.   Cell Systems

Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion

(2019) Alexandra C. Walls et al.   CELL

Principles for Integrative Structural Biology Studies

(2019) Michael P. Rout et al.   CELL

A high-speed search engine pLink 2 with systematic evaluation for proteome-scale identification of cross-linked peptides

(2019) Zhen-Lin Chen et al.   Nature Communications

The Therapeutic Potential of Nanobodies

(2019) Ivana Jovčevska et al.   BIODRUGS

Quantitative mass imaging of single biological macromolecules

(2018) Gavin Young et al.   SCIENCE

Integrative structure and functional anatomy of a nuclear pore complex

(2018) Seung Joong Kim et al.   NATURE

Caplacizumab: First Global Approval

(2018) Sean Duggan   DRUGS

Structural evaluation of a nanobody targeting complement receptor Vsig4 and its cross reactivity

(2017) Yurong Wen et al.   IMMUNOBIOLOGY

Nanobodies® † †Nanobody is a registered trademark of Ablynx NV. as inhaled biotherapeutics for lung diseases

(2017) Gino Van Heeke et al.   PHARMACOLOGY & THERAPEUTICS

Integrative structure modeling with the Integrative Modeling Platform

(2017) Benjamin Webb et al.   PROTEIN SCIENCE

Nanobodies and Nanobody-Based Human Heavy Chain Antibodies As Antitumor Therapeutics

(2017) Peter Bannas et al.   Frontiers in Immunology

A Robust Workflow for Native Mass Spectrometric Analysis of Affinity-Isolated Endogenous Protein Assemblies

(2016) Paul Dominic B. Olinares et al.   ANALYTICAL CHEMISTRY

Optimizing selection of large animals for antibody production by screening immune response to standard vaccines

(2016) Mary K. Thompson et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Prediction of multidimensional drug dose responses based on measurements of drug pairs

(2016) Anat Zimmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BRAID: A Unifying Paradigm for the Analysis of Combined Drug Action

(2016) Nathaniel R. Twarog et al.   Scientific Reports

Structure, Function, and Evolution of Coronavirus Spike Proteins

(2016) Fang Li   Annual Review of Virology

A strategy for dissecting the architectures of native macromolecular assemblies

(2015) Yi Shi et al.   NATURE METHODS

Emerging technologies in point-of-care molecular diagnostics for resource-limited settings

(2014) Rosanna W Peeling et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

A general approach to antibody thermostabilization

(2014) Audrey D McConnell et al.   mAbs

A robust pipeline for rapid production of versatile nanobody repertoires

(2014) Peter C Fridy et al.   NATURE METHODS

A Structurally Distinct Human Mycoplasma Protein that Generically Blocks Antigen-Antibody Union

(2014) R. K. Grover et al.   SCIENCE

Nanobodies: Natural Single-Domain Antibodies

(2013) Serge Muyldermans   Annual Review of Biochemistry

High throughput solution-based measurement of antibody-antigen affinity and epitope binning

(2013) Patricia Estep et al.   mAbs

Virus Neutralisation: New Insights from Kinetic Neutralisation Curves

(2013) Carsten Magnus   PLoS Computational Biology

Cross-linking/mass spectrometry as a new field and the proteomics information mountain of tomorrow

(2012) Juri Rappsilber   Expert Review of Proteomics

Human Monoclonal Antibodies against Highly Conserved HR1 and HR2 Domains of the SARS-CoV Spike Protein Are More Broadly Neutralizing

(2012) Hatem A. Elshabrawy et al.   PLoS One

Clustering biomolecular complexes by residue contacts similarity

(2012) João P. G. L. M. Rodrigues et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Putting the Pieces Together: Integrative Modeling Platform Software for Structure Determination of Macromolecular Assemblies

(2012) Daniel Russel et al.   PLOS BIOLOGY

General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold

(2008) Cécile Vincke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improved tumor targeting of anti-epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular Nanobody technology

(2008) B. M. Tijink et al.   MOLECULAR CANCER THERAPEUTICS