A general approach to antibody thermostabilization

Mutational Analysis of 48G7 Reveals that Somatic Hypermutation Affects Both Antibody Stability and Binding Affinity

(2013) Sophie B. Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineering a therapeutic IgG molecule to address cysteinylation, aggregation and enhance thermal stability and expression

(2013) Andrew Buchanan et al.   mAbs

Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation

(2013) Feng Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toward aggregation-resistant antibodies by design

(2013) Christine C. Lee et al.   TRENDS IN BIOTECHNOLOGY

Structure-Based Design of Supercharged, Highly Thermoresistant Antibodies

(2012) Aleksandr E. Miklos et al.   CHEMISTRY & BIOLOGY

Engineering Aggregation Resistance in IgG by Two Independent Mechanisms: Lessons from Comparison of Pichia pastoris and Mammalian Cell Expression

(2012) Jonas V. Schaefer et al.   JOURNAL OF MOLECULAR BIOLOGY

Rugged Single Domain Antibody Detection Elements for Bacillus anthracis Spores and Vegetative Cells

(2012) Scott A. Walper et al.   PLoS One

High Affinity Humanized Antibodies without Making Hybridomas; Immunization Paired with Mammalian Cell Display and In Vitro Somatic Hypermutation

(2012) Audrey D. McConnell et al.   PLoS One

An integrated approach to extreme thermostabilization and affinity maturation of an antibody

(2012) A. D. McConnell et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions

(2012) J. M. Perchiacca et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Beyond natural antibodies: the power of in vitro display technologies

(2011) Andrew R M Bradbury et al.   NATURE BIOTECHNOLOGY

Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies

(2011) P. M. Bowers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered Human Antibody Constant Domains with Increased Stability

(2009) Rui Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design of therapeutic proteins with enhanced stability

(2009) N. Chennamsetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire

(2009) J. Glanville et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody production, design and use for biosensor-based applications

(2009) Paul J. Conroy et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Single-domain antibodies as building blocks for novel therapeutics

(2008) D SAERENS et al.   CURRENT OPINION IN PHARMACOLOGY

Contribution of Variable Domains to the Stability of Humanized IgG1 Monoclonal Antibodies

(2007) Roxana M. Ionescu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES