Cytolysin A (ClyA): A Bacterial Virulence Factor with Potential Applications in Nanopore Technology, Vaccine Development, and Tumor Therapy

Biological Nanopores: Engineering on Demand

(2021) Ana Crnković et al.   Life-Basel

Structural Basis of the Pore-Forming Toxin/Membrane Interaction

(2021) Yajuan Li et al.   Toxins

Promising Extracellular Vesicle-Based Vaccines against Viruses, Including SARS-CoV-2

(2021) Berina Sabanovic et al.   Biology-Basel

Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology

(2021) Keman Cheng et al.   Nature Communications

Microbiota–host communications: Bacterial extracellular vesicles as a common language

(2021) Rogers A. Ñahui Palomino et al.   PLoS Pathogens

Bacterial Outer Membrane Vesicles: From Discovery to Applications

(2021) Mariana G. Sartorio et al.   Annual Review of Microbiology

RBD-Modified Bacterial Vesicles Elicited Potential Protective Immunity against SARS-CoV-2

(2021) Zhongqian Yang et al.   NANO LETTERS

Engineered Bacteria Enhance Immunotherapy and Targeted Therapy through Stromal Remodeling of Tumors

(2021) Shindu C. Thomas et al.   Advanced Healthcare Materials

Complete, closed bacterial genomes from microbiomes using nanopore sequencing

(2020) Eli L. Moss et al.   NATURE BIOTECHNOLOGY

Rapamycin Re-Directs Lysosome Network, Stimulates ER-Remodeling, Involving Membrane CD317 and Affecting Exocytosis, in Campylobacter Jejuni-Lysate-Infected U937 Cells

(2020) Barbara Canonico et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bacterial Membrane Vesicles as Mediators of Microbe – Microbe and Microbe – Host Community Interactions

(2020) Julie C. Caruana et al.   Frontiers in Microbiology

Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults

(2020) Mark J. Mulligan et al.   NATURE

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

SlyA Transcriptional Regulator Is Not Directly Affected by ppGpp Levels

(2020) Julia Bartoli et al.   Frontiers in Microbiology

Mechanistic Insights into Pore Formation by an α-Pore Forming Toxin: Protein and Lipid Bilayer Interactions of Cytolysin A

(2020) Pradeep Sathyanarayana et al.   ACCOUNTS OF CHEMICAL RESEARCH

Bacterial Outer Membrane Vesicles Presenting Programmed Death 1 for Improved Cancer Immunotherapy via Immune Activation and Checkpoint Inhibition

(2020) Yao Li et al.   ACS Nano

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic bacteria to combat cancer; current advances, challenges, and opportunities

(2019) Mansour Sedighi et al.   Cancer Medicine

High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers

(2019) Wei Peng et al.   PLoS One

Identification and structural analysis of the tripartite α-pore forming toxin of Aeromonas hydrophila

(2019) Jason S. Wilson et al.   Nature Communications

Electrode-free nanopore sensing by DiffusiOptoPhysiology

(2019) Yuqin Wang et al.   Science Advances

Engineering of protein nanopores for sequencing, chemical or protein sensing and disease diagnosis

(2018) Shaoying Wang et al.   CURRENT OPINION IN BIOTECHNOLOGY

Cholesterol promotes Cytolysin A activity by stabilizing the intermediates during pore formation

(2018) Pradeep Sathyanarayana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Third Revolution in Sequencing Technology

(2018) Erwin L. van Dijk et al.   TRENDS IN GENETICS

Monocyte Response to Different Campylobacter jejuni Lysates Involves Endoplasmic Reticulum Stress and the Lysosomal–Mitochondrial Axis: When Cell Death Is Better Than Cell Survival

(2018) Barbara Canonico et al.   Toxins

Structural and Mechanistic Features of ClyA-Like α-Pore-Forming Toxins

(2018) Bastian Bräuning et al.   Toxins

Types and origins of bacterial membrane vesicles

(2018) Masanori Toyofuku et al.   NATURE REVIEWS MICROBIOLOGY

Assembly mechanism of the α-pore–forming toxin cytolysin A from Escherichia coli

(2017) Daniel Roderer et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Single-molecule nanopore enzymology

(2017) Kherim Willems et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response

(2017) Oh Youn Kim et al.   Nature Communications

Bacterial toxins: Offensive, defensive, or something else altogether?

(2017) Justine K. Rudkin et al.   PLoS Pathogens

Host cell interactions of outer membrane vesicle-associated virulence factors of enterohemorrhagic Escherichia coli O157: Intracellular delivery, trafficking and mechanisms of cell injury

(2017) Martina Bielaszewska et al.   PLoS Pathogens

Bacterial Toxins for Cancer Therapy

(2017) et al.   Toxins

DNA Translocation through Nanopores at Physiological Ionic Strengths Requires Precise Nanoscale Engineering

(2016) Lorenzo Franceschini et al.   ACS Nano

Three decades of nanopore sequencing

(2016) David Deamer et al.   NATURE BIOTECHNOLOGY

Recombinant M2e outer membrane vesicle vaccines protect against lethal influenza A challenge in BALB/c mice

(2016) C. Garrett Rappazzo et al.   VACCINE

Plug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunization

(2016) Karl D. Brune et al.   Scientific Reports

Employing Escherichia coli-derived outer membrane vesicles as an antigen delivery platform elicits protective immunity against Acinetobacter baumannii infection

(2016) Weiwei Huang et al.   Scientific Reports

Single-Molecule Analyte Recognition with ClyA Nanopores Equipped with Internal Protein Adaptors

(2015) Misha Soskine et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A complete bacterial genome assembled de novo using only nanopore sequencing data

(2015) Nicholas J Loman et al.   NATURE METHODS

Pore-forming toxins: ancient, but never really out of fashion

(2015) Matteo Dal Peraro et al.   NATURE REVIEWS MICROBIOLOGY

The assembly dynamics of the cytolytic pore toxin ClyA

(2015) Stephan Benke et al.   Nature Communications

Bioengineered Bacterial Outer Membrane Vesicles as Cell-Specific Drug-Delivery Vehicles for Cancer Therapy

(2014) Vipul Gujrati et al.   ACS Nano

RpoS integrates CRP, Fis, and PhoP signaling pathways to control Salmonella Typhi hlyE expression

(2014) Matías R Jofré et al.   BMC MICROBIOLOGY

Elevated recombinant clyA gene expression in the uropathogenic Escherichia coli strain 536, a clue to explain pathoadaptive mutations in a subset of extraintestinal E. coli strains

(2014) Constance Oben Ayuk Enow et al.   BMC MICROBIOLOGY

The Type 1 secretion pathway — The hemolysin system and beyond

(2013) Sabrina Thomas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Role of Pore-Forming Toxins in Bacterial Infectious Diseases

(2013) F. C. O. Los et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

A nanopore machine promotes the vectorial transport of DNA across membranes

(2013) Lorenzo Franceschini et al.   Nature Communications

General Aspects and Recent Advances on Bacterial Protein Toxins

(2013) E. Lemichez et al.   Cold Spring Harbor Perspectives in Medicine

An Engineered ClyA Nanopore Detects Folded Target Proteins by Selective External Association and Pore Entry

(2012) Misha Soskine et al.   NANO LETTERS

Haemolysin E- and enterohaemolysin-derived haemolytic activity of O55/O157 strains and other Escherichia coli lineages

(2011) K. Murase et al.   MICROBIOLOGY-SGM

Biological Functions and Biogenesis of Secreted Bacterial Outer Membrane Vesicles

(2010) Adam Kulp et al.   Annual Review of Microbiology

Mutations Affecting Export and Activity of Cytolysin A from Escherichia coli

(2010) A. Ludwig et al.   JOURNAL OF BACTERIOLOGY

Selective Sorting of Cargo Proteins into Bacterial Membrane Vesicles

(2010) M. Florencia Haurat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Delivery of foreign antigens by engineered outer membrane vesicle vaccines

(2010) D. J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane injury by pore-forming proteins

(2009) Mirko Bischofberger et al.   CURRENT OPINION IN CELL BIOLOGY

Bacterial delivery of a novel cytolysin to hypoxic areas of solid tumors

(2009) R M Ryan et al.   GENE THERAPY

A novel PhoP-regulated locus encoding the cytolysin ClyA and the secreted invasin TaiA of Salmonella enterica serovar Typhi is involved in virulence

(2009) S. P. Faucher et al.   MICROBIOLOGY-SGM

The structure of a cytolytic α-helical toxin pore reveals its assembly mechanism

(2009) Marcus Mueller et al.   NATURE

Continuous base identification for single-molecule nanopore DNA sequencing

(2009) James Clarke et al.   Nature Nanotechnology

Single-nucleotide discrimination in immobilized DNA oligonucleotides with a biological nanopore

(2009) D. Stoddart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RpoS- and Crp-dependent transcriptional control of Salmonella Typhi taiA and hlyE genes: role of environmental conditions

(2009) Juan A. Fuentes et al.   RESEARCH IN MICROBIOLOGY

Occurrence and characteristics of the cytolysin A gene inShigellastrains and other members of the familyEnterobacteriaceae

(2008) Christine von Rhein et al.   FEMS MICROBIOLOGY LETTERS

ClyA cytolysin from Salmonella: Distribution within the genus, regulation of expression by SlyA, and pore-forming characteristics

(2008) C VONRHEIN et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Engineered Bacterial Outer Membrane Vesicles with Enhanced Functionality

(2008) Jae-Young Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

Bacillus cereus Nhe is a pore-forming toxin with structural and functional properties similar to the ClyA (HlyE, SheA) family of haemolysins, able to induce osmotic lysis in epithelia

(2008) A. Fagerlund et al.   MICROBIOLOGY-SGM

The potential and challenges of nanopore sequencing

(2008) Daniel Branton et al.   NATURE BIOTECHNOLOGY

The Salmonella Typhi hlyE gene plays a role in invasion of cultured epithelial cells and its functional transfer to S. Typhimurium promotes deep organ infection in mice

(2008) Juan A. Fuentes et al.   RESEARCH IN MICROBIOLOGY