New insights into the role of endosomal proteins for African swine fever virus infection

Ebola virus glycoprotein interacts with cholesterol to enhance membrane fusion and cell entry

(2021) Jinwoo Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

African Swine Fever Virus Ubiquitin-Conjugating Enzyme Interacts With Host Translation Machinery to Regulate the Host Protein Synthesis

(2021) Lucía Barrado-Gil et al.   Frontiers in Microbiology

Identification of Niemann-Pick C1 protein as a potential novel SARS-CoV-2 intracellular target

(2021) Isabel García-Dorival et al.   ANTIVIRAL RESEARCH

The lysosome: A potential juncture between SARS‐CoV‐2 infectivity and Niemann‐Pick disease type C, with therapeutic implications

(2020) Rami A. Ballout et al.   FASEB JOURNAL

Potential COVID-19 therapeutics from a rare disease: Weaponizing lipid dysregulation to combat viral infectivity

(2020) Stephen Sturley et al.   JOURNAL OF LIPID RESEARCH

Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2

(2020) Hongwu Qian et al.   CELL

NPC1 as a Modulator of Disease Severity and Viral Entry of Sars-CoV-2

(2020) Cecilia Vial et al.   CURRENT MOLECULAR MEDICINE

African Swine Fever Virus Protein pE199L Mediates Virus Entry by Enabling Membrane Fusion and Core Penetration

(2020) Tania Matamoros et al.   mBio

The cryo-EM structure of African swine fever virus unravels a unique architecture comprising two icosahedral protein capsids and two lipoprotein membranes

(2019) German Andres et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Architecture of African swine fever virus and implications for viral assembly

(2019) Nan Wang et al.   SCIENCE

U18666A inhibits classical swine fever virus replication through interference with intracellular cholesterol trafficking

(2019) Xiao-Dong Liang et al.   VETERINARY MICROBIOLOGY

African Swine Fever Epidemiology and Control

(2019) Linda K. Dixon et al.   Annual Review of Animal Biosciences

Cryo-EM Structure of the African Swine Fever Virus

(2019) Sheng Liu et al.   Cell Host & Microbe

Mechanisms of cellular cholesterol compartmentalization: recent insights

(2018) Elina Ikonen   CURRENT OPINION IN CELL BIOLOGY

The Role of Host Cholesterol During Flavivirus Infection

(2018) Juan Fidel Osuna-Ramos et al.   Frontiers in Cellular and Infection Microbiology

Hepatitis C Virus Replication Depends on Endosomal Cholesterol Homeostasis

(2017) Ina Karen Stoeck et al.   JOURNAL OF VIROLOGY

Redistribution of Endosomal Membranes to the African Swine Fever Virus Replication Site

(2017) Miguel Cuesta-Geijo et al.   Viruses-Basel

The ubiquitin-proteasome system is required for African swine fever replication

(2017) Lucía Barrado-Gil et al.   PLoS One

Imipramine Inhibits Chikungunya Virus Replication in Human Skin Fibroblasts through Interference with Intracellular Cholesterol Trafficking

(2017) Sineewanlaya Wichit et al.   Scientific Reports

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

(2016) Xin Gong et al.   CELL

Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1

(2016) Han Wang et al.   CELL

Elucidation of the Cellular Interactome of Ebola Virus Nucleoprotein and Identification of Therapeutic Targets

(2016) Isabel García-Dorival et al.   JOURNAL OF PROTEOME RESEARCH

African Swine Fever Virus Undergoes Outer Envelope Disruption, Capsid Disassembly and Inner Envelope Fusion before Core Release from Multivesicular Endosomes

(2016) Bruno Hernáez et al.   PLoS Pathogens

Lysosomal membrane glycoproteins bind cholesterol and contribute to lysosomal cholesterol export

(2016) Jian Li et al.   eLife

Cholesterol Flux Is Required for Endosomal Progression of African Swine Fever Virions during the Initial Establishment of Infection

(2015) Miguel Ángel Cuesta-Geijo et al.   JOURNAL OF VIROLOGY

African swine fever virus infects macrophages, the natural host cells, via clathrin- and cholesterol-dependent endocytosis

(2015) Inmaculada Galindo et al.   VIRUS RESEARCH

Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection

(2015) Feiran Lu et al.   eLife

Oxysterol-Binding Protein Is a Phosphatidylinositol 4-Kinase Effector Required for HCV Replication Membrane Integrity and Cholesterol Trafficking

(2014) Hongliang Wang et al.   GASTROENTEROLOGY

Elucidation of the Ebola Virus VP24 Cellular Interactome and Disruption of Virus Biology through Targeted Inhibition of Host-Cell Protein Function

(2014) Isabel García-Dorival et al.   JOURNAL OF PROTEOME RESEARCH

Modulation of Hepatitis C Virus Genome Replication by Glycosphingolipids and Four-Phosphate Adaptor Protein 2

(2014) I. Khan et al.   JOURNAL OF VIROLOGY

Lassa virus entry requires a trigger-induced receptor switch

(2014) L. T. Jae et al.   SCIENCE

Ezetimibe blocks hepatitis B virus infection after virus uptake into hepatocytes

(2012) Julie Lucifora et al.   ANTIVIRAL RESEARCH

Ebola virus entry requires the host-programmed recognition of an intracellular receptor

(2012) Emily Happy Miller et al.   EMBO JOURNAL

Identification of the Niemann-Pick C1–like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor

(2012) Bruno Sainz et al.   NATURE MEDICINE

Endosomal Maturation, Rab7 GTPase and Phosphoinositides in African Swine Fever Virus Entry

(2012) Miguel A. Cuesta-Geijo et al.   PLoS One

African Swine Fever Virus Uses Macropinocytosis to Enter Host Cells

(2012) Elena G. Sánchez et al.   PLoS Pathogens

Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

(2011) Marceline Côté et al.   NATURE

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

Niemann–Pick C2 (NPC2) and intracellular cholesterol trafficking

(2009) Judith Storch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

(2009) Hyock Joo Kwon et al.   CELL

Ebolavirusglycoprotein structure and mechanism of entry

(2009) Jeffrey E Lee et al.   Future Virology

Role for LAMP-2 in endosomal cholesterol transport

(2009) Alexander Schneede et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Deficiency of Niemann-Pick Type C-1 Protein Impairs Release of Human Immunodeficiency Virus Type 1 and Results in Gag Accumulation in Late Endosomal/Lysosomal Compartments

(2009) Y. Tang et al.   JOURNAL OF VIROLOGY

The African Swine Fever Virus Virion Membrane Protein pE248R Is Required for Virus Infectivity and an Early Postentry Event

(2009) I. Rodriguez et al.   JOURNAL OF VIROLOGY

The structure and function of Niemann???Pick C1-like 1 protein

(2008) Liqing Yu   CURRENT OPINION IN LIPIDOLOGY