Ebola virus glycoprotein interacts with cholesterol to enhance membrane fusion and cell entry

Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding

(2020) Dibyendu Kumar Das et al.   PLOS BIOLOGY

Target Membrane Cholesterol Modulates Single Influenza Virus Membrane Fusion Efficiency but Not Rate

(2020) Katherine N. Liu et al.   BIOPHYSICAL JOURNAL

Virion-Associated Cholesterol Regulates the Infection of Human Parainfluenza Virus Type 3

(2019) Qiaopeng Tang et al.   Viruses-Basel

Science under fire: Ebola researchers fight to test drugs and vaccines in a war zone

(2019) Amy Maxmen   NATURE

An exploration of conditions proposed to trigger the Ebola virus glycoprotein for fusion

(2019) Lucie Fénéant et al.   PLoS One

A Hyperstabilizing Mutation in the Base of the Ebola Virus Glycoprotein Acts at Multiple Steps To Abrogate Viral Entry

(2019) J. Maximilian Fels et al.   mBio

Identification of Combinations of Approved Drugs With Synergistic Activity Against Ebola Virus in Cell Cultures

(2018) Julie Dyall et al.   JOURNAL OF INFECTIOUS DISEASES

Cholesterol enhances influenza binding avidity by controlling nanoscale receptor clustering

(2018) I. N. Goronzy et al.   Chemical Science

Statins Suppress Ebola Virus Infectivity by Interfering with Glycoprotein Processing

(2018) Punya Shrivastava-Ranjan et al.   mBio

A molecular mechanism for calcium-mediated synaptotagmin-triggered exocytosis

(2018) Volker Kiessling et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Ebola virus envelope protein MPER/TM domain and its interaction with the fusion loop explains their fusion activity

(2017) Jinwoo Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Herpes Simplex Virus 1 Envelope Cholesterol Facilitates Membrane Fusion

(2017) George A. Wudiri et al.   Frontiers in Microbiology

Reconstitution of calcium-mediated exocytosis of dense-core vesicles

(2017) Alex J. B. Kreutzberger et al.   Science Advances

HIV virions sense plasma membrane heterogeneity for cell entry

(2017) Sung-Tae Yang et al.   Science Advances

Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1

(2016) Han Wang et al.   CELL

The role of cholesterol in membrane fusion

(2016) Sung-Tae Yang et al.   CHEMISTRY AND PHYSICS OF LIPIDS

The Tetherin Antagonism of the Ebola Virus Glycoprotein Requires an Intact Receptor-Binding Domain and Can Be Blocked by GP1-Specific Antibodies

(2016) Constantin Brinkmann et al.   JOURNAL OF VIROLOGY

Post-Ebola syndrome

(2016) Talha Khan Burki   LANCET INFECTIOUS DISEASES

Fusion of Enveloped Viruses in Endosomes

(2016) Judith M. White et al.   TRAFFIC

Line tension at lipid phase boundaries as driving force for HIV fusion peptide-mediated fusion

(2016) Sung-Tae Yang et al.   Nature Communications

Influenza viral membrane fusion is sensitive to sterol concentration but surprisingly robust to sterol chemical identity

(2016) Katarzyna E. Zawada et al.   Scientific Reports

The hemifusion structure induced by influenza virus haemagglutinin is determined by physical properties of the target membranes

(2016) Petr Chlanda et al.   Nature Microbiology

A cholesterol consensus motif is required for efficient intracellular transport and raft association of a group 2 HA from influenza virus

(2015) Maren de Vries et al.   BIOCHEMICAL JOURNAL

Hemagglutinin Spatial Distribution Shifts in Response to Cholesterol in the Influenza Viral Envelope

(2015) Marta K. Domanska et al.   BIOPHYSICAL JOURNAL

High Cholesterol Obviates a Prolonged Hemifusion Intermediate in Fast SNARE-Mediated Membrane Fusion

(2015) Alex J.B. Kreutzberger et al.   BIOPHYSICAL JOURNAL

Post-Ebolavirus disease syndrome: what do we know?

(2015) Francisco Javier Carod-Artal   Expert Review of Anti-Infective Therapy

Host Cell Plasma Membrane Phosphatidylserine Regulates the Assembly and Budding of Ebola Virus

(2015) Emmanuel Adu-Gyamfi et al.   JOURNAL OF VIROLOGY

HIV gp41–mediated membrane fusion occurs at edges of cholesterol-rich lipid domains

(2015) Sung-Tae Yang et al.   Nature Chemical Biology

Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

(2015) Yasuteru Sakurai et al.   SCIENCE

A screen of approved drugs and molecular probes identifies therapeutics with anti–Ebola virus activity

(2015) Lisa M. Johansen et al.   Science Translational Medicine

Treating the Host Response to Ebola Virus Disease with Generic Statins and Angiotensin Receptor Blockers

(2015) David S. Fedson et al.   mBio

Inhibition of Ebola virus glycoprotein-mediated cytotoxicity by targeting its transmembrane domain and cholesterol

(2015) Moritz Hacke et al.   Nature Communications

Ebolavirus Entry Requires a Compact Hydrophobic Fist at the Tip of the Fusion Loop

(2014) S. M. Gregory et al.   JOURNAL OF VIROLOGY

Multiphasic Effects of Cholesterol on Influenza Fusion Kinetics Reflect Multiple Mechanistic Roles

(2013) Marta K. Domanska et al.   BIOPHYSICAL JOURNAL

Vesicle fusion to planar membranes is enhanced by cholesterol and low temperature

(2012) David E. Lee et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Fusion Activity of HIV gp41 Fusion Domain Is Related to Its Secondary Structure and Depth of Membrane Insertion in a Cholesterol-Dependent Fashion

(2012) Alex L. Lai et al.   JOURNAL OF MOLECULAR BIOLOGY

Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

(2011) Marceline Côté et al.   NATURE

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

Measuring the Strength of Interaction between the Ebola Fusion Peptide and Lipid Rafts: Implications for Membrane Fusion and Virus Infection

(2011) Mônica S. Freitas et al.   PLoS One

Structure and function of the complete internal fusion loop from Ebolavirus glycoprotein 2

(2011) S. M. Gregory et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus

(2011) A. S. Kondratowicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Designed protein mimics of the Ebola virus glycoprotein GP2 α-helical bundle: Stability and pH effects

(2011) Joseph S. Harrison et al.   PROTEIN SCIENCE

Docking and Fast Fusion of Synaptobrevin Vesicles Depends on the Lipid Compositions of the Vesicle and the Acceptor SNARE Complex-Containing Target Membrane

(2010) Marta K. Domanska et al.   BIOPHYSICAL JOURNAL

Single SNARE-Mediated Vesicle Fusion Observed In Vitro by Polarized TIRFM

(2010) Volker Kiessling et al.   BIOPHYSICAL JOURNAL

Ebola haemorrhagic fever

(2010) Heinz Feldmann et al.   LANCET

Single Vesicle Millisecond Fusion Kinetics Reveals Number of SNARE Complexes Optimal for Fast SNARE-mediated Membrane Fusion

(2009) Marta K. Domanska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Gaussian Curvature Elastic Energy of Intermediates in Membrane Fusion

(2008) David P. Siegel   BIOPHYSICAL JOURNAL

Structures and Mechanisms of Viral Membrane Fusion Proteins: Multiple Variations on a Common Theme

(2008) Judith M. White et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Cholesterol Promotes Hemifusion and Pore Widening in Membrane Fusion Induced by Influenza Hemagglutinin

(2008) Subrata Biswas et al.   JOURNAL OF GENERAL PHYSIOLOGY

Identification of the LWYIK Motif Located in the Human Immunodeficiency Virus Type 1 Transmembrane gp41 Protein as a Distinct Determinant for Viral Infection

(2008) S. S.-L. Chen et al.   JOURNAL OF VIROLOGY

Viral membrane fusion

(2008) Stephen C Harrison   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Single-particle kinetics of influenza virus membrane fusion

(2008) D. L. Floyd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA