The cyclic nucleotide–binding homology domain of the integral membrane protein CNNM mediates dimerization and is required for Mg2+ efflux activity

CrossTalk proposal: CNNM proteins are Na+ /Mg2+ exchangers playing a central role in transepithelial Mg2+ (re)absorption

(2018) Yosuke Funato et al.   JOURNAL OF PHYSIOLOGY-LONDON

CrossTalk opposing view: CNNM proteins are not Na+ /Mg2+ exchangers but Mg2+ transport regulators playing a central role in transepithelial Mg2+ (re)absorption

(2018) Francisco J. Arjona et al.   JOURNAL OF PHYSIOLOGY-LONDON

Structural insights into the mechanisms of CNBD channel function

(2017) Zachary M. James et al.   JOURNAL OF GENERAL PHYSIOLOGY

PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3

(2017) Huizhi Zhang et al.   Scientific Reports

Phosphocysteine in the PRL‐CNNM pathway mediates magnesium homeostasis

(2016) Irina Gulerez et al.   EMBO REPORTS

Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2

(2016) Paula Giménez-Mascarell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new familial case of Jalili syndrome caused by a novel mutation in CNNM4

(2016) Vehap Topçu et al.   OPHTHALMIC GENETICS

Structure of theLegionellaEffector, lpg1496, Suggests a Role in Nucleotide Metabolism

(2015) Kathy Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Magnesium in Man: Implications for Health and Disease

(2015) Jeroen H. F. de Baaij et al.   PHYSIOLOGICAL REVIEWS

Structure of the SthK Carboxy-Terminal Region Reveals a Gating Mechanism for Cyclic Nucleotide-Modulated Ion Channels

(2015) Divya Kesters et al.   PLoS One

Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure

(2014) María Ángeles Corral-Rodríguez et al.   BIOCHEMICAL JOURNAL

Mg2+-dependent Interactions of ATP with the Cystathionine-β-Synthase (CBS) Domains of a Magnesium Transporter

(2014) Yusuke Hirata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane protein CNNM4–dependent Mg2+ efflux suppresses tumor progression

(2014) Yosuke Funato et al.   JOURNAL OF CLINICAL INVESTIGATION

Determinants of ligand selectivity in a cyclic nucleotide–regulated potassium channel

(2014) João Pessoa et al.   JOURNAL OF GENERAL PHYSIOLOGY

The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis

(2014) S Hardy et al.   ONCOGENE

The structure and regulation of magnesium selective ion channels

(2013) Jian Payandeh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The structural mechanism of KCNH-channel regulation by the eag domain

(2013) Yoni Haitin et al.   NATURE

Basolateral Mg2+ Extrusion via CNNM4 Mediates Transcellular Mg2+ Transport across Epithelia: A Mouse Model

(2013) Daisuke Yamazaki et al.   PLoS Genetics

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Membrane Topology and Intracellular Processing of Cyclin M2 (CNNM2)

(2012) Jeroen H. F. de Baaij et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the carboxy-terminal region of a KCNH channel

(2012) Tinatin I. Brelidze et al.   NATURE

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

CNNM2, Encoding a Basolateral Protein Required for Renal Mg2+ Handling, Is Mutated in Dominant Hypomagnesemia

(2011) Marchel Stuiver et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Second messenger role for Mg2+ revealed by human T-cell immunodeficiency

(2011) Feng-Yen Li et al.   NATURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Developments in the US-SOMO Bead Modeling Suite: New Features in the Direct Residue-to-Bead Method, Improved Grid Routines, and Influence of Accessible Surface Area Screening

(2010) Emre Brookes et al.   MACROMOLECULAR BIOSCIENCE

Dali server: conservation mapping in 3D

(2010) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

Mutations in CNNM4 Cause Recessive Cone-Rod Dystrophy with Amelogenesis Imperfecta

(2009) Bozena Polok et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in CNNM4 Cause Jalili Syndrome, Consisting of Autosomal-Recessive Cone-Rod Dystrophy and Amelogenesis Imperfecta

(2009) David A. Parry et al.   AMERICAN JOURNAL OF HUMAN GENETICS