Translational control of ERK signaling through miRNA/4EHP-directed silencing

PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs

(2018) Kyle A. Cottrell et al.   Nature Communications

GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression

(2017) Daniel Peter et al.   GENES & DEVELOPMENT

Cap-binding protein 4EHP effects translation silencing by microRNAs

(2017) Clément Chapat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs

(2017) Aitor Garzia et al.   Nature Communications

Translation efficiency is a determinant of the magnitude of miRNA-mediated repression

(2017) Kyle A. Cottrell et al.   Scientific Reports

Differential Sensitivity of Target Genes to Translational Repression by miR-17~92

(2017) Hyun Yong Jin et al.   PLoS Genetics

MicroRNAs recruit eIF4E2 to repress translation of target mRNAs

(2017) Shaohong Chen et al.   Protein & Cell

Dual specificity phosphatase 6 deficiency is associated with impaired systemic glucose tolerance and reversible weight retardation in mice

(2017) Katrin Pfuhlmann et al.   PLoS One

The DDX6–4E-T interaction mediates translational repression and P-body assembly

(2016) Anastasiia Kamenska et al.   NUCLEIC ACIDS RESEARCH

Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia

(2015) Seyedmehdi Shojaee et al.   CANCER CELL

Towards a molecular understanding of microRNA-mediated gene silencing

(2015) Stefanie Jonas et al.   NATURE REVIEWS GENETICS

Structure of a Human 4E-T/DDX6/CNOT1 Complex Reveals the Different Interplay of DDX6-Binding Proteins with the CCR4-NOT Complex

(2015) Sevim Ozgur et al.   Cell Reports

Predicting effective microRNA target sites in mammalian mRNAs

(2015) Vikram Agarwal et al.   eLife

Constitutively active Ras negatively regulates Erk MAP kinase through induction of MAP kinase phosphatase 3 (MKP3) in NIH3T3 cells

(2015) Young Jae Park et al.   BMB Reports

Cancer Cells Exploit eIF4E2-Directed Synthesis of Hypoxia Response Proteins to Drive Tumor Progression

(2014) J. Uniacke et al.   CANCER RESEARCH

Integrated Genomic Characterization of Papillary Thyroid Carcinoma

(2014) Nishant Agrawal et al.   CELL

MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease

(2014) J. Banzhaf-Strathmann et al.   EMBO JOURNAL

mRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues

(2014) Stephen W. Eichhorn et al.   MOLECULAR CELL

Targeting RAS–ERK signalling in cancer: promises and challenges

(2014) Ahmed A. Samatar et al.   NATURE REVIEWS DRUG DISCOVERY

Rapid Induction of Apoptosis by PI3K Inhibitors Is Dependent upon Their Transient Inhibition of RAS-ERK Signaling

(2014) M. Will et al.   Cancer Discovery

Assessing gene-level translational control from ribosome profiling

(2013) Adam B. Olshen et al.   BIOINFORMATICS

The Translational Landscape of the Mammalian Cell Cycle

(2013) Craig R. Stumpf et al.   MOLECULAR CELL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing

(2013) A. Kamenska et al.   NUCLEIC ACIDS RESEARCH

Translational control by 3'-UTR-binding proteins

(2012) E. Szostak et al.   Briefings in Functional Genomics

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells

(2012) Julien Béthune et al.   EMBO REPORTS

Dual-specificity MAP kinase phosphatases (MKPs)

(2012) Christopher J. Caunt et al.   FEBS Journal

A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development

(2012) M. Morita et al.   MOLECULAR AND CELLULAR BIOLOGY

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

(2012) Guangjin Li et al.   NATURE MEDICINE

The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments

(2012) Nicholas T Ingolia et al.   Nature Protocols

HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA

(2012) Pradipta Kundu et al.   NUCLEIC ACIDS RESEARCH

miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay

(2012) S. Djuranovic et al.   SCIENCE

Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish

(2012) A. A. Bazzini et al.   SCIENCE

Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes

(2011) Nicholas T. Ingolia et al.   CELL

Cap in hand: Targeting eIF4E

(2011) Peter M. Fischer   CELL CYCLE

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

Kaposi's Sarcoma Herpesvirus microRNAs Target Caspase 3 and Regulate Apoptosis

(2011) Guillaume Suffert et al.   PLoS Pathogens

Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells

(2010) Zhenfeng Zhang et al.   CARCINOGENESIS

Post-transcriptional regulation of the DUSP6/MKP-3 phosphatase by MEK/ERK signaling and hypoxia

(2010) Olga Bermudez et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

A Pumilio-induced RNA structure switch in p27-3′ UTR controls miR-221 and miR-222 accessibility

(2010) Martijn Kedde et al.   NATURE CELL BIOLOGY

The relationship between the evolution of microRNA targets and the length of their UTRs

(2009) Chao Cheng et al.   BMC GENOMICS

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

ERK and cell death: Mechanisms of ERK-induced cell death - apoptosis, autophagy and senescence

(2009) Sebastien Cagnol et al.   FEBS Journal

Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation

(2009) Marc R. Fabian et al.   MOLECULAR CELL

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages

(2009) Gabriela Molina et al.   Nature Chemical Biology

Identification of miR-21 targets in breast cancer cells using a quantitative proteomic approach

(2009) Yi Yang et al.   PROTEOMICS

Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within theDUSP6/MKP-3gene promoter

(2008) Maria Ekerot et al.   BIOCHEMICAL JOURNAL

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

Post-translational regulation of the ERK phosphatase DUSP6/MKP3 by the mTOR pathway

(2008) O Bermudez et al.   ONCOGENE

Comparative Analysis of mRNA Targets for Human PUF-Family Proteins Suggests Extensive Interaction with the miRNA Regulatory System

(2008) Alessia Galgano et al.   PLoS One