Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets

ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity

(2021) Michael Shum et al.   Science Translational Medicine

Comparison of N-ethyl maleimide and N-(1-phenylethyl) maleimide for derivatization of biological thiols using liquid chromatography-mass spectrometry

(2020) Mariana S. T. Russo et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

MetaboAnalystR 3.0: Toward an Optimized Workflow for Global Metabolomics

(2020) Zhiqiang Pang et al.   Metabolites

Pancreatic β-cells detoxify H2O2 through the peroxiredoxin/thioredoxin antioxidant system

(2019) Jennifer S. Stancill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver

(2019) David A. Cappel et al.   Cell Metabolism

Oxidative stress pathways in pancreatic beta cells and insulin sensitive cells and tissues - importance to cell metabolism, function and dysfunction

(2019) Philip Newsholme et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes

(2019) Maria Lytrivi et al.   JOURNAL OF MOLECULAR BIOLOGY

Nutrient Metabolism, Subcellular Redox State, and Oxidative Stress in Pancreatic Islets and β-Cells

(2019) Leticia P. Roma et al.   JOURNAL OF MOLECULAR BIOLOGY

Divergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation

(2018) Atsushi Miki et al.   PLoS One

Differential expression of islet glutaredoxin 1 and 5 with high reactive oxygen species production in a mouse model of diabesity

(2017) Sebastian Friedrich Petry et al.   PLoS One

Metabolic Stress and Compromised Identity of Pancreatic Beta Cells

(2017) Avital Swisa et al.   Frontiers in Genetics

Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

(2016) Melissa F. Brereton et al.   Nature Communications

The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells

(2016) Xiaomu Li et al.   Nature Communications

Phospho-BAD BH3 Mimicry Protects β Cells and Restores Functional β Cell Mass in Diabetes

(2015) Sanda Ljubicic et al.   Cell Reports

The Furan Fatty Acid Metabolite CMPF Is Elevated in Diabetes and Induces β Cell Dysfunction

(2014) Kacey J. Prentice et al.   Cell Metabolism

Regulation of Hepatic Energy Metabolism and Gluconeogenesis by BAD

(2014) Alfredo Giménez-Cassina et al.   Cell Metabolism

Minireview: Thioredoxin-Interacting Protein: Regulation and Function in the Pancreatic β-Cell

(2014) Anath Shalev   MOLECULAR ENDOCRINOLOGY

The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis

(2013) Lindsey E. Padgett et al.   Annals of the New York Academy of Sciences

Metabolic Signaling in Fuel-Induced Insulin Secretion

(2013) Marc Prentki et al.   Cell Metabolism

Inflammation in Obesity and Diabetes: Islet Dysfunction and Therapeutic Opportunity

(2013) Marc Y. Donath et al.   Cell Metabolism

A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators

(2013) Benjamin Szlyk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ChREBP Mediates Glucose-Stimulated Pancreatic  -Cell Proliferation

(2012) M. R. Metukuri et al.   DIABETES

Glucose metabolism: key endogenous regulator of β-cell replication and survival

(2012) D. Dadon et al.   DIABETES OBESITY & METABOLISM

The molecular mechanisms of pancreatic β-cell glucotoxicity: Recent findings and future research directions

(2012) Mohammed Bensellam et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

High-Throughput, Accurate Mass Metabolome Profiling of Cellular Extracts by Flow Injection–Time-of-Flight Mass Spectrometry

(2011) Tobias Fuhrer et al.   ANALYTICAL CHEMISTRY

Measuring EGSH and H2O2 with roGFP2-based redox probes

(2011) Bruce Morgan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst

(2011) Jianguo Xia et al.   Nature Protocols

Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD–severe combined immunodeficiency (SCID) mice

(2010) H. E. Levitt et al.   DIABETOLOGIA

Regulation of insulin secretion: role of mitochondrial signalling

(2010) S. Jitrapakdee et al.   DIABETOLOGIA

Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion

(2009) Emma Heart et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Proximity-based Protein Thiol Oxidation by H2O2-scavenging Peroxidases

(2009) Marcus Gutscher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Metabolic cycling in control of glucose-stimulated insulin secretion

(2008) Mette V. Jensen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The role of pyruvate carboxylase in insulin secretion and proliferation in rat pancreatic beta cells

(2008) J. Xu et al.   DIABETOLOGIA

Dual role of proapoptotic BAD in insulin secretion and beta cell survival

(2008) Nika N Danial et al.   NATURE MEDICINE

Real-time imaging of the intracellular glutathione redox potential

(2008) Marcus Gutscher et al.   NATURE METHODS