Natural and Designed Proteins Inspired by Extremotolerant Organisms Can Form Condensates and Attenuate Apoptosis in Human Cells

Biomolecular condensates and cancer

(2021) Ann Boija et al.   CANCER CELL

Water content influences the vitrified properties of CAHS proteins

(2021) Thomas C. Boothby   MOLECULAR CELL

Reconsidering the “glass transition” hypothesis of intrinsically unstructured CAHS proteins in desiccation tolerance of tardigrades

(2021) Kazuharu Arakawa et al.   MOLECULAR CELL

Aducanumab: a new phase in therapeutic development for Alzheimer’s disease?

(2021) Giovanna Lalli et al.   EMBO Molecular Medicine

Intrinsically Disordered Tardigrade Proteins Self‐Assemble into Fibrous Gels in Response to Environmental Stress

(2021) Anas Malki et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protection by desiccation‐tolerance proteins probed at the residue level

(2021) Candice J. Crilly et al.   PROTEIN SCIENCE

Physical Principles Underlying the Complex Biology of Intracellular Phase Transitions

(2020) Jeong-Mo Choi et al.   Annual Review of Biophysics

Stress- and ubiquitylation-dependent phase separation of the proteasome

(2020) Sayaka Yasuda et al.   NATURE

Liquid-liquid phase separation promotes animal desiccation tolerance

(2020) Clinton Belott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Molecular Basis for Apolipoprotein E4 as the Major Risk Factor for Late-Onset Alzheimer's Disease

(2019) Ana-Caroline Raulin et al.   JOURNAL OF MOLECULAR BIOLOGY

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

Proteomic analysis of eleven tissues in the Chinese giant salamander (Andrias davidianus)

(2019) Xiaofang Geng et al.   Scientific Reports

Probing and engineering liquid-phase organelles

(2019) Dan Bracha et al.   NATURE BIOTECHNOLOGY

Chemically induced proximity in biology and medicine

(2018) Benjamin Z. Stanton et al.   SCIENCE

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

LEA Proteins and the Evolution of the WHy Domain

(2018) Jasmin Mertens et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

(2018) Ann Boija et al.   CELL

Mapping Local and Global Liquid Phase Behavior in Living Cells Using Photo-Oligomerizable Seeds

(2018) Dan Bracha et al.   CELL

P-Body Purification Reveals the Condensation of Repressed mRNA Regulons

(2017) Arnaud Hubstenberger et al.   MOLECULAR CELL

Tardigrades Use Intrinsically Disordered Proteins to Survive Desiccation

(2017) Thomas C. Boothby et al.   MOLECULAR CELL

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

Exploring the repeat protein universe through computational protein design

(2015) TJ Brunette et al.   NATURE

Novel Mitochondria-Targeted Heat-Soluble Proteins Identified in the Anhydrobiotic Tardigrade Improve Osmotic Tolerance of Human Cells

(2015) Sae Tanaka et al.   PLoS One

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)

(2014) Francois-Xavier Theillet et al.   CHEMICAL REVIEWS

X-Linked Inhibitor of Apoptosis Protein – A Critical Death Resistance Regulator and Therapeutic Target for Personalized Cancer Therapy

(2014) Petra Obexer et al.   Frontiers in Oncology

The Bacterial Cytoplasm Has Glass-like Properties and Is Fluidized by Metabolic Activity

(2013) Bradley R. Parry et al.   CELL

Late embryogenesis abundant proteins protect human hepatoma cells during acute desiccation

(2012) S. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LEA Proteins During Water Stress: Not Just for Plants Anymore

(2011) Steven C. Hand et al.   Annual Review of Physiology

Catalytic and chaperone-like functions in an intrinsically disordered protein associated with desiccation tolerance

(2010) S. Chakrabortee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid Fibrillation of Human Apaf-1 CARD

(2009) P. Nageswara Rao et al.   BIOCHEMISTRY

Protection of Neurons from Apoptosis by Apolipoprotein E-containing Lipoproteins Does Not Require Lipoprotein Uptake and Involves Activation of Phospholipase Cγ1 and Inhibition of Calcineurin

(2009) Hideki Hayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

De novo identification of highly diverged protein repeats by probabilistic consistency

(2008) A. Biegert et al.   BIOINFORMATICS

Tardigrades survive exposure to space in low Earth orbit

(2008) K. Ingemar Jönsson et al.   CURRENT BIOLOGY

Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways

(2008) Kyoko Arimoto et al.   NATURE CELL BIOLOGY