Multiocular organoids from human induced pluripotent stem cells displayed retinal, corneal, and retinal pigment epithelium lineages

Generation of functional conjunctival epithelium, including goblet cells, from human iPSCs

(2021) Kimihito Nomi et al.   Cell Reports

Engineering organoids

(2021) Moritz Hofer et al.   Nature Reviews Materials

Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors

(2021) Joana Ribeiro et al.   Cell Reports

Repopulation of decellularized retinas with hiPSC-derived retinal pigment epithelial and ocular progenitor cells shows cell engraftment, organization and differentiation

(2021) Maria Maqueda et al.   BIOMATERIALS

Transplantation of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium in a Swine Model of Geographic Atrophy

(2021) Anna Duarri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective effects of human iPS-derived retinal pigmented epithelial cells on retinal degenerative disease

(2020) Deliang Zhu et al.   Stem Cell Research & Therapy

Do not keep it simple: recent advances in the generation of complex organoids

(2020) Philipp Wörsdörfer et al.   JOURNAL OF NEURAL TRANSMISSION

Human organoids: model systems for human biology and medicine

(2020) Jihoon Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ocular surface ectoderm instigated by WNT inhibition and BMP4

(2020) Yuki Kobayashi et al.   Stem Cell Research

Cell spheroid fusion: beyond liquid drops model

(2020) Nastasia V. Kosheleva et al.   Scientific Reports

The Use of Induced Pluripotent Stem Cells as a Model for Developmental Eye Disorders

(2020) Jonathan Eintracht et al.   Frontiers in Cellular Neuroscience

Corneal development: Role of the periocular mesenchyme and bi-directional signaling

(2020) Haydn Walker et al.   EXPERIMENTAL EYE RESEARCH

Organoids and organ chips in ophthalmology

(2020) Navid Manafi et al.   Ocular Surface

Human corneal limbal organoids maintaining limbal stem cell niche function

(2020) Kazunari Higa et al.   Stem Cell Research

Transcriptomics analysis of Ccl2/Cx3cr1/Crb1rd8 deficient mice provides new insights into the pathophysiology of progressive retinal degeneration

(2020) Anna Badia et al.   EXPERIMENTAL EYE RESEARCH

Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents

(2019) Ting Zou et al.   Nature Communications

Rapid Differentiation of Multi-Zone Ocular Cells from Human Induced Pluripotent Stem Cells and Generation of Corneal Epithelial and Endothelial Cells

(2019) Zongyi Li et al.   STEM CELLS AND DEVELOPMENT

CRX Expression in Pluripotent Stem Cell-Derived Photoreceptors Marks a Transplantable Subpopulation of Early Cones

(2019) Joseph Collin et al.   STEM CELLS

An integrated transcriptional analysis of the developing human retina

(2019) Carla B. Mellough et al.   DEVELOPMENT

Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in the Subretinal Space of the Cat Eye

(2019) Ratnesh K. Singh et al.   STEM CELLS AND DEVELOPMENT

Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells

(2019) Liqing Song et al.   Scientific Reports

Dexamethasone Provides Effective Immunosuppression for Improved Survival of Retinal Organoids after Epiretinal Transplantation

(2019) Bikun Xian et al.   Stem Cells International

Generation of complex human organoid models including vascular networks by incorporation of mesodermal progenitor cells

(2019) Philipp Wörsdörfer et al.   Scientific Reports

Retinogenesis of the Human Fetal Retina: An Apical Polarity Perspective

(2019) Peter M.J. Quinn et al.   Genes

Regenerating Eye Tissues to Preserve and Restore Vision

(2018) Jeffrey H. Stern et al.   Cell Stem Cell

Organoid technology for retinal repair

(2018) Sílvia Llonch et al.   DEVELOPMENTAL BIOLOGY

Relationship between neural crest cell specification and rare ocular diseases

(2018) Monica Akula et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Organoids

(2018) Natalie de Souza   NATURE METHODS

Feeder-free differentiation of cells exhibiting characteristics of corneal endothelium from human induced pluripotent stem cells

(2018) Michael D. Wagoner et al.   Biology Open

Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients

(2018) Wen-Li Deng et al.   Stem Cell Reports

In vitrodrusen model – three-dimensional spheroid culture of retinal pigment epithelial cells

(2018) Hideaki Usui et al.   JOURNAL OF CELL SCIENCE

Characterization and Transplantation of CD73-Positive Photoreceptors Isolated from Human iPSC-Derived Retinal Organoids

(2018) Giuliana Gagliardi et al.   Stem Cell Reports

Thyroid hormone signaling specifies cone subtypes in human retinal organoids

(2018) Kiara C. Eldred et al.   SCIENCE

Microglia innately develop within cerebral organoids

(2018) Paul R. Ormel et al.   Nature Communications

Selective Laminin-Directed Differentiation of Human Induced Pluripotent Stem Cells into Distinct Ocular Lineages

(2018) Shun Shibata et al.   Cell Reports

Coordinated generation of multiple ocular-like cell lineages and fabrication of functional corneal epithelial cell sheets from human iPS cells

(2017) Ryuhei Hayashi et al.   Nature Protocols

Generation of Transplantable Retinal Photoreceptors from a Current Good Manufacturing Practice-Manufactured Human Induced Pluripotent Stem Cell Line

(2017) Jie Zhu et al.   Stem Cells Translational Medicine

Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis

(2017) Seth R Flaxman et al.   Lancet Global Health

Cornea organoids from human induced pluripotent stem cells

(2017) James W. Foster et al.   Scientific Reports

Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells

(2017) Karl J. Wahlin et al.   Scientific Reports

Subretinal implantation of a monolayer of human embryonic stem cell-derived retinal pigment epithelium: a feasibility and safety study in Yucatán minipigs

(2016) Michael J. Koss et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Co-ordinated ocular development from human iPS cells and recovery of corneal function

(2016) Ryuhei Hayashi et al.   NATURE

Comparative study of human embryonic stem cells (hESC) and human induced pluripotent stem cells (hiPSC) as a treatment for retinal dystrophies

(2016) Marina Riera et al.   Molecular Therapy-Methods & Clinical Development

IGF-1 Signaling Plays an Important Role in the Formation of Three-Dimensional Laminated Neural Retina and Other Ocular Structures From Human Embryonic Stem Cells

(2015) Carla B. Mellough et al.   STEM CELLS

Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue

(2015) Atsushi Kuwahara et al.   Nature Communications

An Update on Ocular Surface Epithelial Stem Cells: Cornea and Conjunctiva

(2015) Tiago Ramos et al.   Stem Cells International

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E

(2014) Khandakar A.S.M. Saadat et al.   FEBS Open Bio

Cell fate determination in the vertebrate retina

(2012) Erin A. Bassett et al.   TRENDS IN NEUROSCIENCES

The Retinal Pigment Epithelium in Health and Disease

(2010) J. R. Sparrrow et al.   CURRENT MOLECULAR MEDICINE

Generation of Induced Pluripotent Stem Cells from Human Cord Blood Using OCT4 and SOX2

(2009) Alessandra Giorgetti et al.   Cell Stem Cell

Regulation of Neural Specification from Human Embryonic Stem Cells by BMP and FGF

(2009) Timothy M. LaVaute et al.   STEM CELLS

Inhibition of Activin/Nodal signaling promotes specification of human embryonic stem cells into neuroectoderm

(2007) Joseph R. Smith et al.   DEVELOPMENTAL BIOLOGY