Repositioning of a novel GABA-B receptor agonist, AZD3355 (Lesogaberan), for the treatment of non-alcoholic steatohepatitis

Modeling dysbiosis of human NASH in mice: Loss of gut microbiome diversity and overgrowth of Erysipelotrichales

(2021) James K. Carter et al.   PLoS One

Selonsertib for Patients with Bridging Fibrosis or Compensated Cirrhosis Due to NASH: Results from Randomized Ph III STELLAR Trials

(2020) Stephen A. Harrison et al.   JOURNAL OF HEPATOLOGY

Women have Lower Risk of Nonalcoholic Fatty Liver Disease but Higher Risk of Progression vs Men: A Systematic Review and Meta-analysis

(2020) Maya Balakrishnan et al.   Clinical Gastroenterology and Hepatology

Why do so many NASH trials fail?

(2020) Vlad Ratziu et al.   GASTROENTEROLOGY

Hepatic molecular signatures highlight the sexual dimorphism of Non‐Alcoholic SteatoHepatitis (NASH)

(2020) Jimmy Vandel et al.   HEPATOLOGY

Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0

(2020) Nathalie Percie du Sert et al.   PLOS BIOLOGY

Sex Differences in NAFLD : State of the Art and Identification of Research Gaps

(2019) Amedeo Lonardo et al.   HEPATOLOGY

A Bioreactor Technology for Modeling Fibrosis in Human and Rodent Precision‐Cut Liver Slices

(2019) Hannah L. Paish et al.   HEPATOLOGY

Trends in clinical success rates and therapeutic focus

(2019) Helen Dowden et al.   NATURE REVIEWS DRUG DISCOVERY

pcaExplorer: an R/Bioconductor package for interacting with RNA-seq principal components

(2019) Federico Marini et al.   BMC BIOINFORMATICS

AKR1C1‑3, notably AKR1C3, are distinct biomarkers for liver cancer diagnosis and prognosis: Database mining in malignancies

(2019) Shou‑Feng Zhao et al.   Oncology Letters

Distinct molecular etiologies of male and female hepatocellular carcinoma

(2019) Heini M. Natri et al.   BMC CANCER

Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics

(2019) Alan Talevi et al.   Expert Opinion on Drug Discovery

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

(2019) Zobair M Younossi et al.   LANCET

A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer

(2018) Takuma Tsuchida et al.   JOURNAL OF HEPATOLOGY

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Impact of a five-dimensional framework on R&D productivity at AstraZeneca

(2018) Paul Morgan et al.   NATURE REVIEWS DRUG DISCOVERY

eXpression2Kinases (X2K) Web: linking expression signatures to upstream cell signaling networks

(2018) Daniel J B Clarke et al.   NUCLEIC ACIDS RESEARCH

Burden of Illness and Economic Model for Patients with Non-Alcoholic Steatohepatitis (NASH) in the United States

(2018) Zobair M. Younossi et al.   HEPATOLOGY

Global Perspectives on Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis

(2018) Zobair Younossi et al.   HEPATOLOGY

CXCL6-EGFR-induced Kupffer cells secrete TGF-β1 promoting hepatic stellate cell activation via the SMAD2/BRD4/C-MYC/EZH2 pathway in liver fibrosis

(2018) Xiaobo Cai et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Risk of Hepatocellular Cancer in Patients With Non-Alcoholic Fatty Liver Disease

(2018) Fasiha Kanwal et al.   GASTROENTEROLOGY

Temporal Trends Associated With the Rise in Alcoholic Liver Disease-related Liver Transplantation in the United States

(2018) George Cholankeril et al.   TRANSPLANTATION

Using Big Data to Discover Diagnostics and Therapeutics for Gastrointestinal and Liver Diseases

(2017) Benjamin Wooden et al.   GASTROENTEROLOGY

Nextflow enables reproducible computational workflows

(2017) Paolo Di Tommaso et al.   NATURE BIOTECHNOLOGY

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Ribosomal protein S15a promotes tumor angiogenesis via enhancing Wnt/β-catenin-induced FGF18 expression in hepatocellular carcinoma

(2017) Pengyi Guo et al.   ONCOGENE

Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells

(2017) Daniel F. Hicks et al.   Scientific Reports

Predicting the Reliability of Drug-target Interaction Predictions with Maximum Coverage of Target Space

(2017) Antonio Peón et al.   Scientific Reports

Extraction and analysis of signatures from the Gene Expression Omnibus by the crowd

(2016) Zichen Wang et al.   Nature Communications

FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis

(2016) Len Verbeke et al.   Scientific Reports

Failure of Investigational Drugs in Late-Stage Clinical Development and Publication of Trial Results

(2016) Thomas J. Hwang et al.   JAMA Internal Medicine

Smad7 regulates compensatory hepatocyte proliferation in damaged mouse liver and positively relates to better clinical outcome in human hepatocellular carcinoma

(2015) Teng Feng et al.   CLINICAL SCIENCE

A hepatic stellate cell gene expression signature associated with outcomes in hepatitis C cirrhosis and hepatocellular carcinoma after curative resection

(2015) David Y Zhang et al.   GUT

Dose-dependent effects of lesogaberan on reflux measures in patients with refractory gastroesophageal reflux disease: a randomized, placebo-controlled study

(2014) Philip B Miner et al.   BMC GASTROENTEROLOGY

Inverse correlation of ribosomal protein S27A and multifunctional protein YB-1 in hepatocellular carcinoma

(2014) Vinoth Prasanna Gunasekaran et al.   CLINICAL BIOCHEMISTRY

A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors

(2013) N. S. Jahchan et al.   Cancer Discovery

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Antifibrotic Activity of Sorafenib in Experimental Hepatic Fibrosis: Refinement of Inhibitory Targets, Dosing, and Window of Efficacy In Vivo

(2012) Feng Hong et al.   DIGESTIVE DISEASES AND SCIENCES

Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis

(2012) Luciano Adorini et al.   DRUG DISCOVERY TODAY

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

A novel reflux inhibitor lesogaberan (AZD3355) as add-on treatment in patients with GORD with persistent reflux symptoms despite proton pump inhibitor therapy: a randomised placebo-controlled trial

(2011) G. E. Boeckxstaens et al.   GUT

Upregulation of Hemoglobin Expression by Oxidative Stress in Hepatocytes and Its Implication in Nonalcoholic Steatohepatitis

(2011) Wensheng Liu et al.   PLoS One

Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease

(2011) J. T. Dudley et al.   Science Translational Medicine

Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

(2011) M. Sirota et al.   Science Translational Medicine

The novel, peripherally restricted GABAB receptor agonist lesogaberan (AZD3355) inhibits acid reflux and reduces esophageal acid exposure as measured with 24-h pHmetry in dogs

(2010) Lena Brändén et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of Lesogaberan on Reflux and Lower Esophageal Sphincter Function in Patients With Gastroesophageal Reflux Disease

(2010) Guy E. Boeckxstaens et al.   GASTROENTEROLOGY

The GABAB Receptor Inhibits Activation of Hepatic Stellate Cells

(2009) Fan Xiao et al.   DIGESTIVE DISEASES AND SCIENCES

Identifying Apoptosis-Evasion Proteins/Pathways in Human Hepatoma Cells via Induction of Cellular Hormesis by UV Irradiation

(2009) Sen-Yung Hsieh et al.   JOURNAL OF PROTEOME RESEARCH

GABAB receptors as drug targets to treat gastroesophageal reflux disease

(2009) Anders Lehmann   PHARMACOLOGY & THERAPEUTICS

Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage

(2008) William S. Blaner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Synthesis and Pharmacological Evaluation of Novel γ-Aminobutyric Acid Type B (GABAB) Receptor Agonists as Gastroesophageal Reflux Inhibitors

(2008) Christer Alstermark et al.   JOURNAL OF MEDICINAL CHEMISTRY

Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma

(2008) Yujin Hoshida et al.   NEW ENGLAND JOURNAL OF MEDICINE