Histone methyltransferase DOT1L mediates the TGF-β1/Smad3 signaling pathway through epigenetic modification of SYK in myocardial infarction

GRK5 is a regulator of fibroblast activation and cardiac fibrosis

(2021) Akito Eguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diagnostic and Prognostic Biomarkers for Myocardial Infarction

(2021) Yuling Wu et al.   Frontiers in Cardiovascular Medicine

FOXF1 ameliorates angiotensin II-induced cardiac fibrosis in cardiac fibroblasts through inhibiting the TGF-β1/Smad3 signaling pathway

(2020) Daoxin Jin et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Nullifying epigenetic writer DOT1L attenuates neointimal hyperplasia

(2020) Yitao Huang et al.   ATHEROSCLEROSIS

The Expression and Clinical Significance of Spleen Tyrosine Kinase in Patients with Coronary Heart Disease

(2019) Ke Liang et al.   MEDICAL SCIENCE MONITOR

Targeting SYK signaling in myeloid cells protects against liver fibrosis and hepatocarcinogenesis

(2019) Alejandro Torres-Hernandez et al.   ONCOGENE

Blocking the histone lysine 79 methyltransferase DOT1L alleviates renal fibrosis through inhibition of renal fibroblast activation and epithelial-mesenchymal transition

(2019) Lirong Liu et al.   FASEB JOURNAL

Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice

(2019) Sangeeta Maity et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Histone H3 K79 Methyltransferase Dot1l Facilitates Kidney Fibrosis by Upregulating Endothelin 1 through Histone Deacetylase 2

(2019) Long Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inhibition of Disruptor of Telomeric Silencing 1-Like Alleviated Renal Ischemia and Reperfusion Injury-Induced Fibrosis by Blocking PI3K/AKT-Mediated Oxidative Stress

(2019) Chuan Yang et al.   Drug Design Development and Therapy

Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer

(2019) Liqun Yang et al.   Clinical Epigenetics

Spleen Tyrosine Kinase (SYK) in the Progression of Peritoneal Fibrosis Through Activation of the TGF-β1/Smad3 Signaling Pathway

(2019) Kang-Han Liu et al.   MEDICAL SCIENCE MONITOR

New insights into TGF-β/Smad signaling in tissue fibrosis

(2018) He-He Hu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Tyrosine kinase SYK is a potential therapeutic target for liver fibrosis

(2018) Chen Qu et al.   HEPATOLOGY

Prognostic value of spleen tyrosine kinase in human solid tumors

(2018) Beibei Ni et al.   OncoTargets and Therapy

The upstreams and downstreams of H3K79 methylation by DOT1L

(2016) Hanneke Vlaming et al.   CHROMOSOMA

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

The role of DOT1L in the maintenance of leukemia gene expression

(2016) Xi Wang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Inhibition of spleen tyrosine kinase (syk) suppresses renal fibrosis through anti-inflammatory effects and down regulation of the MAPK-p38 pathway

(2016) Kuan-Hsing Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese

(2014) Megumi Hirokawa et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Hypermethylation and prognostic implication of Syk gene in human colorectal cancer

(2013) Zuli Yang et al.   MEDICAL ONCOLOGY

The promoter methylation of the Syk gene in nasopharyngeal carcinoma cell lines

(2012) CHONG YAN et al.   Oncology Letters

Deficiency of H3K79 Histone Methyltransferase Dot1-like Protein (DOT1L) Inhibits Cell Proliferation

(2011) Wootae Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression and methylation status of the Syk gene in cervical carcinoma

(2010) Shuping Zhao et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

A Novel and Efficient Model of Coronary Artery Ligation and Myocardial Infarction in the Mouse

(2010) Erhe Gao et al.   CIRCULATION RESEARCH

Research on the reactivation of Syk expression caused by the inhibition of DNA promoter methylation in the lung cancer

(2010) S. DONG et al.   NEOPLASMA