Apple phenolic extracts ameliorate lead-induced cognitive impairment and depression- and anxiety-like behavior in mice by abating oxidative stress, inflammation and apoptosis via the miR-22-3p/SIRT1 axis

Therapeutic effects of biochanin A, phloretin, and epigallocatechin-3-gallate in reducing oxidative stress in arsenic-intoxicated mice

(2021) Gyanendra Singh et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Dietary EPA‐Enriched Phospholipids Alleviate Chronic Stress and LPS‐Induced Depression‐ and Anxiety‐Like Behavior by Regulating Immunity and Neuroinflammation

(2021) Cheng‐Cheng Wang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Chlorogenic acid alleviates neurobehavioral disorders and brain damage in focal ischemia animal models

(2021) Murad-Ali Shah et al.   NEUROSCIENCE LETTERS

Protective Effect of Chlorogenic Acid and Its Analogues on Lead-Induced Developmental Neurotoxicity Through Modulating Oxidative Stress and Autophagy

(2021) Xiuna Ji et al.   Frontiers in Molecular Biosciences

Protocatechuic acid mitigates cadmium-induced neurotoxicity in rats: Role of oxidative stress, inflammation and apoptosis

(2020) Ebtesam M. Al Olayan et al.   SCIENCE OF THE TOTAL ENVIRONMENT

SIRT1 is a key regulatory target for the treatment of the endoplasmic reticulum stress-related organ damage

(2020) Fuquan Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Astragaloside IV-induced Nrf2 nuclear translocation ameliorates lead-related cognitive impairments in mice

(2020) Chunlei Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Moringa oleifera Lam. extract rescues lead‐induced oxidative stress, inflammation, and apoptosis in the rat cerebral cortex

(2020) Wedad S. Alqahtani et al.   JOURNAL OF FOOD BIOCHEMISTRY

Apple polyphenols extract alleviated dextran sulfate sodium‐induced ulcerative colitis in C57BL /6 male mice by restoring bile acid metabolism disorder and gut microbiota dysbiosis

(2020) Fang Liu et al.   PHYTOTHERAPY RESEARCH

Chlorogenic acid confers robust neuroprotection against arsenite toxicity in mice by reversing oxidative stress, inflammation, and apoptosis

(2020) Dina M. Metwally et al.   Journal of Functional Foods

Microglia-mediated neuroinflammation in neurodegenerative diseases

(2019) Charannya Sozheesvari Subhramanyam et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Long‐term consequences of early postnatal lead exposure on hippocampal synaptic activity in adult mice

(2019) Anahis Tena et al.   Brain and Behavior

Phloretin attenuates behavior deficits and neuroinflammatory response in MPTP induced Parkinson's disease in mice

(2019) Gejuan Zhang et al.   LIFE SCIENCES

The Neuroprotective Role of Coenzyme Q10 Against Lead Acetate-Induced Neurotoxicity Is Mediated by Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities

(2019) Al Omar S. Yousef et al.   International Journal of Environmental Research and Public Health

Procyanidin B2 Suppresses Lipopolysaccharides-Induced Inflammation and Apoptosis in Human Type II Alveolar Epithelial Cells and Lung Fibroblasts

(2019) Yinling Jiang et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Simultaneous determination of four flavonoids in rat plasma after oral administration of Malus hupehensis (Pamp.) Rehd. extracts by UPLC‐MS/MS and its application to a pharmacokinetics study

(2019) Dongyan Guo et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Antagonistic Efficacy of Luteolin against Lead Acetate Exposure-Associated with Hepatotoxicity is Mediated via Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Activities

(2019) Wafa A. AL-Megrin et al.   Antioxidants

Behavioral and neurochemical consequences of perinatal exposure to lead in adult male Wistar rats: protective effect by Centella asiatica

(2018) Swetha Chintapanti et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Resveratrol Boosts Cognitive Function by Targeting SIRT1

(2018) Wenyan Cao et al.   NEUROCHEMICAL RESEARCH

Pharmacokinetics and brain penetration study of chlorogenic acid in rats

(2018) Gaurav Kumar et al.   XENOBIOTICA

Bax, Bcl-2, and Bax/Bcl-2 as prognostic markers in acute myeloid leukemia: are we ready for Bcl-2-directed therapy?

(2018) Bibi Kulsoom et al.   Cancer Management and Research

Phlorizin administration ameliorates cognitive deficits by reducing oxidative stress, tau hyper-phosphorylation, and neuroinflammation in a rat model of Alzheimer’s disease

(2018) Yuan Tian et al.   JOURNAL OF FOOD BIOCHEMISTRY

Protective Effects of Dietary Supplements Containing Probiotics, Micronutrients, and Plant Extracts Against Lead Toxicity in Mice

(2018) Qixiao Zhai et al.   Frontiers in Microbiology

The Significance of Regulatory MicroRNAs: Their Roles in Toxicodynamics of Mycotoxins and in the Protection Offered by Dietary Therapeutics Against Mycotoxin-Induced Toxicity

(2018) Xue Rong et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Beneficial effect of catechin and epicatechin on cognitive impairment and oxidative stress induced by extremely low frequency electromagnetic field

(2017) Qing-Han Gao et al.   JOURNAL OF FOOD BIOCHEMISTRY

Antioxidant and hepatoprotective effect of polyphenols from apple pomace extract via apoptosis inhibition and Nrf2 activation in mice

(2016) S Sharma et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Heavy Metals, Cardiovascular Disease, and the Unexpected Benefits of Chelation Therapy

(2016) Gervasio A. Lamas et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages

(2016) Jong-Seok Moon et al.   NATURE MEDICINE

Molecular and Histopathological Study on the Ameliorative Effects of Curcumin Against Lead Acetate-Induced Hepatotoxicity and Nephrototoxicity in Wistar Rats

(2015) Mohamed M. Soliman et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Protective effects of Egyptian cloudy apple juice and apple peel extract on lipid peroxidation, antioxidant enzymes and inflammatory status in diabetic rat pancreas

(2015) Samah M. Fathy et al.   BMC Complementary and Alternative Medicine

Overexpression of SIRT1 Induced by Resveratrol and Inhibitor of miR-204 Suppresses Activation and Proliferation of Microglia

(2015) Lihong Li et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Activation of the Nrf2 defense pathway contributes to neuroprotective effects of phloretin on oxidative stress injury after cerebral ischemia/reperfusion in rats

(2015) Yu Liu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Honey prevents neurobehavioural deficit and oxidative stress induced by lead acetate exposure in male wistar rats- a preliminary study

(2015) Wahab Imam Abdulmajeed et al.   METABOLIC BRAIN DISEASE

Procyanidin B2 attenuates neurological deficits and blood-brain barrier disruption in a rat model of cerebral ischemia

(2015) Shuangchan Wu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Protective effect of apple (Ralls) polyphenol extract against aluminum-induced cognitive impairment and oxidative damage in rat

(2014) Dai Cheng et al.   NEUROTOXICOLOGY

Anti-apoptotic effect of phloretin on cisplatin-induced apoptosis in HEI-OC1 auditory cells

(2014) Byung-Min Choi et al.   Pharmacological Reports

Effects of (−)Epicatechin on the Pathology of APP/PS1 Transgenic Mice

(2014) Yue-Qin Zeng et al.   Frontiers in Neurology

Polyphenols and triterpenes from Chaenomeles fruits: Chemical analysis and antioxidant activities assessment

(2013) Hui Du et al.   FOOD CHEMISTRY

Apple Peel Polyphenols and Their Beneficial Actions on Oxidative Stress and Inflammation

(2013) Marie Claude Denis et al.   PLoS One

Hypotriglyceridemic effects of apple polyphenols extract via up-regulation of lipoprotein lipase in triton WR-1339-induced mice

(2012) Nan Yao et al.   Chinese Journal of Integrative Medicine

Pharmacokinetics and Blood–Brain Barrier Penetration of (+)-Catechin and (−)-Epicatechin in Rats by Microdialysis Sampling Coupled to High-Performance Liquid Chromatography with Chemiluminescence Detection

(2012) Liang Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Mechanism of Oxidative Stress in Neurodegeneration

(2012) Sonia Gandhi et al.   Oxidative Medicine and Cellular Longevity

Effects of Flaxseed Oil on Lead Acetate-Induced Neurotoxicity in Rats

(2011) Ahmed E. Abdel Moneim et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease

(2011) Giuseppa Mudò et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Juices, Fibres and Skin Waste Extracts from White, Pink or Red-Fleshed Apple Genotypes as Potential Food Ingredients

(2011) Dongxiao Sun-Waterhouse et al.   Food and Bioprocess Technology

Neurotoxic Effects and Biomarkers of Lead Exposure: A Review

(2011) T. Sanders et al.   REVIEWS ON ENVIRONMENTAL HEALTH

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Comparative analysis of fruit-based functional snack bars

(2009) D. Sun-Waterhouse et al.   FOOD CHEMISTRY