Dietary EPA‐Enriched Phospholipids Alleviate Chronic Stress and LPS‐Induced Depression‐ and Anxiety‐Like Behavior by Regulating Immunity and Neuroinflammation

EPA is More Effective than DHA to Improve Depression-Like Behavior, Glia Cell Dysfunction and Hippcampal Apoptosis Signaling in a Chronic Stress-Induced Rat Model of Depression

(2020) Zhilan Peng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ameliorative effect of anthocyanin on depression mice by increasing monoamine neurotransmitter and up-regulating BDNF expression

(2020) Ji-Li Fang et al.   Journal of Functional Foods

Acute stress induces chronic neuroinflammatory, microglial and behavioral priming: A role for potentiated NLRP3 inflammasome activation

(2020) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Decreased stress-induced depression-like behavior in lactating rats is associated with changes in the hypothalamic-pituitary-adrenal axis, brain monoamines, and brain amino acid metabolism

(2019) Mizuki Hamada et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Brain eicosapentaenoic acid metabolism as a lead for novel therapeutics in major depression

(2019) Richard P. Bazinet et al.   BRAIN BEHAVIOR AND IMMUNITY

Health benefits of dietary marine DHA/EPA-enriched glycerophospholipids

(2019) Tian-Tian Zhang et al.   PROGRESS IN LIPID RESEARCH

Anhedonic-like behavior correlates with IFNγ serum levels in a two-hit model of depression

(2019) Luiza P. Géa et al.   BEHAVIOURAL BRAIN RESEARCH

Targeting the NLRP3 Inflammasome in Neuroinflammation: Health Promoting Effects of Dietary Phytochemicals in Neurological Disorders

(2019) Wei‐Lun Hung et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Marine omega‐3 (n‐3) phospholipids: A comprehensive review of their properties, sources, bioavailability, and relation to brain health

(2019) Mirja Kaizer Ahmmed et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Eicosapentaenoic acid prevents inflammation induced by acute cerebral infarction through inhibition of NLRP3 inflammasome activation

(2019) Zhihuai Mo et al.   LIFE SCIENCES

Sex differences in the neuro-immune consequences of stress: Focus on depression and anxiety

(2018) Mandakh Bekhbat et al.   BRAIN BEHAVIOR AND IMMUNITY

Maternal n-3 polyunsaturated fatty acid dietary supply modulates microglia lipid content in the offspring

(2018) Charlotte Rey et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

DHA enriched phospholipids with different polar groups (PC and PS) had different improvements on MPTP-induced mice with Parkinson’s disease

(2018) Chengcheng Wang et al.   Journal of Functional Foods

An Ω-3 fatty acid-deficient diet during gestation induces depressive-like behavior in rats: the role of the hypothalamo–pituitary–adrenal (HPA) system

(2018) Mimi Tang et al.   Food & Function

rTMS ameliorated depressive-like behaviors by restoring HPA axis balance and prohibiting hippocampal neuron apoptosis in a rat model of depression

(2018) Lin Zhao et al.   PSYCHIATRY RESEARCH

A comparative study about EPA-PL and EPA-EE on ameliorating behavioral deficits in MPTP-induced mice with Parkinson’s disease by suppressing oxidative stress and apoptosis

(2018) Cheng-Cheng Wang et al.   Journal of Functional Foods

Food for Mood: Relevance of Nutritional Omega-3 Fatty Acids for Depression and Anxiety

(2018) Thomas Larrieu et al.   Frontiers in Physiology

Dietary lysophosphatidylcholine-EPA enriches both EPA and DHA in the brain: Potential treatment for depression

(2018) Poorna ChandraRao Yalagala et al.   JOURNAL OF LIPID RESEARCH

Dietary eicosapentaenoic acid normalizes hippocampal omega-3 and 6 polyunsaturated fatty acid profile, attenuates glial activation and regulates BDNF function in a rodent model of neuroinflammation induced by central interleukin-1β administration

(2017) Yilong Dong et al.   EUROPEAN JOURNAL OF NUTRITION

Anti-Inflammatory Effects of Omega-3 Fatty Acids in the Brain: Physiological Mechanisms and Relevance to Pharmacology

(2017) Sophie Layé et al.   PHARMACOLOGICAL REVIEWS

Behavioral, inflammatory and neurochemical disturbances in LPS and UCMS-induced mouse models of depression

(2017) Xinnan Zhao et al.   BEHAVIOURAL BRAIN RESEARCH

Efficacy of omega-3 highly unsaturated fatty acids in the treatment of depression

(2016) Brian Hallahan et al.   BRITISH JOURNAL OF PSYCHIATRY

Phospholipid supplementation can attenuate vaccine-induced depressive-like behavior in mice

(2016) Shaye Kivity et al.   IMMUNOLOGIC RESEARCH

Activation of the NLRP3 inflammasome in lipopolysaccharide-induced mouse fatigue and its relevance to chronic fatigue syndrome

(2016) Zi-Teng Zhang et al.   Journal of Neuroinflammation

Effects of different fatty acids composition of phosphatidylcholine on brain function of dementia mice induced by scopolamine

(2016) Miao-miao Zhou et al.   Lipids in Health and Disease

The role of omega-3 polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids in the treatment of major depression and Alzheimer's disease: Acting separately or synergistically?

(2016) Cai Song et al.   PROGRESS IN LIPID RESEARCH

National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 2

(2015) Terry A. Jacobson et al.   Journal of Clinical Lipidology

Insulin resistance in brain alters dopamine turnover and causes behavioral disorders

(2015) Andre Kleinridders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

(2014) Long N. Nguyen et al.   NATURE

Polyunsaturated fatty acids and their metabolites in brain function and disease

(2014) Richard P. Bazinet et al.   NATURE REVIEWS NEUROSCIENCE

Role of Omega-3 Fatty Acids in the Treatment of Depressive Disorders: A Comprehensive Meta-Analysis of Randomized Clinical Trials

(2014) Giuseppe Grosso et al.   PLoS One

Nutritional omega-3 modulates neuronal morphology in the prefrontal cortex along with depression-related behaviour through corticosterone secretion

(2014) T Larrieu et al.   Translational Psychiatry

Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation

(2013) Yiqing Yan et al.   IMMUNITY

Eicosapentaenoic acid-enriched phospholipid ameliorates insulin resistance and lipid metabolism in diet-induced-obese mice

(2013) Xiaofang Liu et al.   Lipids in Health and Disease

Increased Expression of the Anti-Apoptotic Protein Bcl-xL in the Brain is Associated with Resilience to Stress-Induced Depression-Like Behavior

(2012) Nikolay N. Dygalo et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Short term effects of different omega-3 fatty acid formulation on lipid metabolism in mice fed high or low fat diet

(2012) Xiao Tang et al.   Lipids in Health and Disease

Using the rat forced swim test to assess antidepressant-like activity in rodents

(2012) David A Slattery et al.   Nature Protocols

The multiple roles of fatty acid handling proteins in brain

(2012) Valentine S. F. Moullé et al.   Frontiers in Physiology

Brain-derived neurotrophic factor (BDNF) infusion restored astrocytic plasticity in the hippocampus of a rat model of depression

(2011) Yuanyuan Ye et al.   NEUROSCIENCE LETTERS

Immune suppression and immune activation in depression

(2010) Joshua Blume et al.   BRAIN BEHAVIOR AND IMMUNITY

Access to the Spleen Microenvironment through Lymph Shows Local Cytokine Production, Increased Cell Flux, and Altered Signaling of Immune Cells during Lipopolysaccharide-Induced Acute Inflammation

(2010) E. Semaeva et al.   JOURNAL OF IMMUNOLOGY

Eicosapentaenoic acid decreases expression of anandamide synthesis enzyme and cannabinoid receptor 2 in osteoblast-like cells

(2010) Heather L. Hutchins et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Prostaglandins of the E series inhibit monoamine release via EP3 receptors: proof with the competitive EP3 receptor antagonist L-826,266

(2009) J. Günther et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Hochu-ekki-to combined with interferon-gamma moderately enhances daily activity of chronic fatigue syndrome mice by increasing NK cell activity, but not neuroprotection

(2008) Rui Chen et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Prevention of chronic stress-induced depression-like behavior by inducible nitric oxide inhibitor

(2008) Dan Wang et al.   NEUROSCIENCE LETTERS

The HPA axis in major depression: classical theories and new developments

(2008) Carmine M. Pariante et al.   TRENDS IN NEUROSCIENCES