Activation of GPR18 by Resolvin D2 Relieves Pain and Improves Bladder Function in Cyclophosphamide-Induced Cystitis Through Inhibiting TRPV1

Interstitial cystitis/bladder pain syndrome: The evolving landscape, animal models and future perspectives

(2020) Yoshiyuki Akiyama et al.   INTERNATIONAL JOURNAL OF UROLOGY

A Novel Alternative in the Treatment of Detrusor Overactivity? In Vivo Activity of O-1602, the Newly Synthesized Agonist of GPR55 and GPR18 Cannabinoid Receptors

(2020) Andrzej Wróbel et al.   MOLECULES

CB1 receptor‐dependent TRPV1 desensitisation contributes to the analgesic effect of dipyrone in sensitised primary sensory neurons

(2020) Gilson Gonçalves dos Santos et al.   BRITISH JOURNAL OF PHARMACOLOGY

O-1602, an Agonist of Atypical Cannabinoid Receptors GPR55, Reverses the Symptoms of Depression and Detrusor Overactivity in Rats Subjected to Corticosterone Treatment

(2020) Andrzej Wróbel et al.   Frontiers in Pharmacology

The effect of O-1602, a GPR55 agonist, on the cyclophosphamide-induced rat hemorrhagic cystitis

(2020) Andrzej Wróbel et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effect of resolvins on sensitisation of TRPV1 and visceral hypersensitivity in IBS

(2020) Eluisa Perna et al.   GUT

Novel selective agonist of GPR18, PSB‐KK‐1415 exerts potent anti‐inflammatory and anti‐nociceptive activities in animal models of intestinal inflammation and inflammatory pain

(2020) Adam Fabisiak et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Suppression of adenosine A2a receptors alleviates bladder overactivity and hyperalgesia in cyclophosphamide-induced cystitis by inhibiting TRPV1

(2020) Yang Yang et al.   BIOCHEMICAL PHARMACOLOGY

A Comprehensive Review of Overactive Bladder Pathophysiology: On the Way to Tailored Treatment

(2019) Benoit Peyronnet et al.   EUROPEAN UROLOGY

Interstitial cystitis, bladder pain syndrome, hypersensitive bladder, and interstitial cystitis/bladder pain syndrome – clarification of definitions and relationships

(2019) Yukio Homma   INTERNATIONAL JOURNAL OF UROLOGY

Anti-cancer and analgesic effects of resolvin D2 in oral squamous cell carcinoma

(2018) Yi Ye et al.   NEUROPHARMACOLOGY

Resolvin D2 Relieving Radicular Pain is Associated with Regulation of Inflammatory Mediators, Akt/GSK-3β Signal Pathway and GPR18

(2018) Lan-yu Zhang et al.   NEUROCHEMICAL RESEARCH

Expression of cannabinoid 1 and, 2 receptors and the effects of cannabinoid 1 and, 2 receptor agonists on detrusor overactivity associated with bladder outlet obstruction in rats

(2017) Sung Dae Kim et al.   BMC Urology

Histamine Receptor H1–Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome

(2016) Mira M. Wouters et al.   GASTROENTEROLOGY

Receptors, channels and signalling in the urothelial sensory system in the bladder

(2016) Liana Merrill et al.   Nature Reviews Urology

Co-administration of transient receptor potential vanilloid 4 (TRPV4) and TRPV1 antagonists potentiate the effect of each drug in a rat model of cystitis

(2015) Ana Charrua et al.   BJU INTERNATIONAL

URB937, a peripherally restricted inhibitor for fatty acid amide hydrolase, reduces prostaglandin E2-induced bladder overactivity and hyperactivity of bladder mechano-afferent nerve fibres in rats

(2015) Naoki Aizawa et al.   BJU INTERNATIONAL

Urinary bladder inflammation induces changes in urothelial nerve growth factor and TRPV1 channels

(2015) A Coelho et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoid receptor expression in the bladder is altered in detrusor overactivity

(2015) Evangelia Bakali et al.   INTERNATIONAL UROGYNECOLOGY JOURNAL

Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy

(2015) Mark S. Wallace et al.   JOURNAL OF PAIN

Increased Severity of Inflammation Correlates with Elevated Expression of TRPV1 Nerve Fibers and Nerve Growth Factor on Interstitial Cystitis/Bladder Pain Syndrome

(2014) Bo-long Liu et al.   UROLOGIA INTERNATIONALIS

Activation of cannabinoid receptor 2 inhibits experimental cystitis

(2013) Zun-Yi Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Role of CXCR2 and TRPV1 in functional, inflammatory and behavioural changes in the rat model of cyclophosphamide-induced haemorrhagic cystitis

(2013) Fabiana N Dornelles et al.   BRITISH JOURNAL OF PHARMACOLOGY

Treatment Costs of Bladder Pain Syndrome/Interstitial Cystitis in Austria: A Pharmacoeconomic Approach Following Current Guidelines

(2013) Claus Riedl et al.   CLINICAL DRUG INVESTIGATION

Cyclophosphamide-induced cystitis reduces ASIC channel but enhances TRPV1 receptor function in rat bladder sensory neurons

(2013) Khoa Dang et al.   JOURNAL OF NEUROPHYSIOLOGY

Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial

(2012) J. Corey-Bloom et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Low-Dose Vaporized Cannabis Significantly Improves Neuropathic Pain

(2012) Barth Wilsey et al.   JOURNAL OF PAIN

Intrathecal Administration of the Cannabinoid 2 Receptor Agonist JWH015 Can Attenuate Cancer Pain and Decrease mRNA Expression of the 2B Subunit of N-Methyl-D-Aspartic Acid

(2011) XiaoPing Gu et al.   ANESTHESIA AND ANALGESIA

AUA Guideline for the Diagnosis and Treatment of Interstitial Cystitis/Bladder Pain Syndrome

(2011) Philip M. Hanno et al.   JOURNAL OF UROLOGY

Local Activation of Cannabinoid CB1 Receptors in the Urinary Bladder Reduces the Inflammation-Induced Sensitization of Bladder Afferents

(2011) Jean-Sébastien Walczak et al.   Molecular Pain

Antinociceptive effect of intrathecal cannabinoid receptor agonist WIN 55,212-2 in a rat bone tumor pain model

(2011) Jin Hua Cui et al.   NEUROSCIENCE LETTERS

The endogenous cannabinoid anandamide inhibits transient receptor potential vanilloid type 1 receptor-mediated currents in rat cultured primary sensory neurons

(2010) P. Sántha et al.   ACTA PHYSIOLOGICA HUNGARICA

Treatment choice, duration, and cost in patients with interstitial cystitis and painful bladder syndrome

(2010) Jennifer T. Anger et al.   INTERNATIONAL UROGYNECOLOGY JOURNAL

Sensor Mechanism and Afferent Signal Transduction of the Urinary Bladder: Special Focus on transient receptor potential Ion Channels

(2010) Masayuki TAKEDA et al.   LUTS-Lower Urinary Tract Symptoms

Distribution and Function of Cannabinoid Receptors 1 and 2 in the Rat, Monkey and Human Bladder

(2009) Christian Gratzke et al.   JOURNAL OF UROLOGY

Cannabinoid CB1 receptors are expressed in the mouse urinary bladder and their activation modulates afferent bladder activity

(2009) J.S. Walczak et al.   NEUROSCIENCE

The neural control of micturition

(2008) Clare J. Fowler et al.   NATURE REVIEWS NEUROSCIENCE

Cannabinoid receptor 2 is increased in acutely and chronically inflamed bladder of rats

(2008) Fabiola Voznika Merriam et al.   NEUROSCIENCE LETTERS

Lack of TRPV1 inhibits cystitis-induced increased mechanical sensitivity in mice

(2008) Zun-Yi Wang et al.   PAIN