Novel selective agonist of GPR18, PSB‐KK‐1415 exerts potent anti‐inflammatory and anti‐nociceptive activities in animal models of intestinal inflammation and inflammatory pain

Evidence for a GPR18 Role in Chemotaxis, Proliferation, and the Course of Wound Closure in the Cornea

(2019) Natalia Murataeva et al.   CORNEA

GPR18 expression on PMNs as biomarker for outcome in patient with sepsis

(2018) Lanqiu Zhang et al.   LIFE SCIENCES

Resolvin D2 Relieving Radicular Pain is Associated with Regulation of Inflammatory Mediators, Akt/GSK-3β Signal Pathway and GPR18

(2018) Lan-yu Zhang et al.   NEUROCHEMICAL RESEARCH

Resolvin RvD2 reduces hypothalamic inflammation and rescues mice from diet-induced obesity

(2017) Livia B. Pascoal et al.   Journal of Neuroinflammation

Novel Resolvin D2 Receptor Axis in Infectious Inflammation

(2016) Nan Chiang et al.   JOURNAL OF IMMUNOLOGY

The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain

(2016) Natalia Malek et al.   PHARMACOLOGICAL RESEARCH

An Orally Active Cannabis Extract with High Content in Cannabidiol attenuates Chemically-induced Intestinal Inflammation and Hypermotility in the Mouse

(2016) Ester Pagano et al.   Frontiers in Pharmacology

GPR18 undergoes a high degree of constitutive trafficking but is unresponsive to N-Arachidonoyl Glycine

(2016) David B. Finlay et al.   PeerJ

Role of G Protein-coupled Orphan Receptors in Intestinal Inflammation

(2015) Andrzej Wasilewski et al.   INFLAMMATORY BOWEL DISEASES

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

(2015) Nan Chiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

G protein coupled receptor 18: A potential role for endocannabinoid signaling in metabolic dysfunction

(2015) Gayathri Rajaraman et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Novel orally available salvinorin A analog PR-38 protects against experimental colitis and reduces abdominal pain in mice by interaction with opioid and cannabinoid receptors

(2014) Maciej Sałaga et al.   BIOCHEMICAL PHARMACOLOGY

Activation of GPR18 by cannabinoid compounds: a tale of biased agonism

(2014) Linda Console-Bram et al.   BRITISH JOURNAL OF PHARMACOLOGY

GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment

(2014) Xiaoming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cannabinoids Alleviate Experimentally Induced Intestinal Inflammation by Acting at Central and Peripheral Receptors

(2014) Jakub Fichna et al.   PLoS One

Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55

(2014) V. Rempel et al.   MedChemComm

TRPV1 and Endocannabinoids: Emerging Molecular Signals that Modulate Mammalian Vision

(2014) Daniel Ryskamp et al.   Cells

GPR18 in microglia: implications for the CNS and endocannabinoid system signalling

(2012) D McHugh   BRITISH JOURNAL OF PHARMACOLOGY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Δ9-Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells

(2011) Douglas McHugh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Resolution of inflammation by N-arachidonoylglycine

(2011) Sumner H. Burstein et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor

(2010) Douglas McHugh et al.   BMC NEUROSCIENCE

N-arachidonyl-glycine modulates synaptic transmission in superficial dorsal horn

(2010) Hyo-Jin Jeong et al.   BRITISH JOURNAL OF PHARMACOLOGY

Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target

(2010) Y. Qin et al.   Pigment Cell & Melanoma Research

Pain and inflammatory bowel disease

(2009) Klaus Bielefeldt et al.   INFLAMMATORY BOWEL DISEASES