Suppression of adenosine A2a receptors alleviates bladder overactivity and hyperalgesia in cyclophosphamide-induced cystitis by inhibiting TRPV1

BDNF promotes activation of astrocytes and microglia contributing to neuroinflammation and mechanical allodynia in cyclophosphamide-induced cystitis

(2020) Honglu Ding et al.   Journal of Neuroinflammation

In Vitro, In Silico, and In Vivo Assessments of Pharmacokinetic Properties of ZM241385

(2020) Jin-Ju Byeon et al.   MOLECULES

Reappraisal of the treatment duration of antibiotic regimens for acute uncomplicated cystitis in adult women: a systematic review and network meta-analysis of 61 randomised clinical trials

(2020) Do Kyung Kim et al.   LANCET INFECTIOUS DISEASES

Neuregulin‐1‐ErbB signaling promotes microglia activation contributing to mechanical allodynia of cyclophosphamide‐induced cystitis

(2019) Jia‐Liang Chen et al.   NEUROUROLOGY AND URODYNAMICS

TRPV1 (Transient Receptor Potential Vanilloid 1) Cardiac Spinal Afferents Contribute to Hypertension in Spontaneous Hypertensive Rat

(2019) Julia Shanks et al.   HYPERTENSION

Pharmacology of Adenosine Receptors: The State of the Art

(2018) Pier Andrea Borea et al.   PHYSIOLOGICAL REVIEWS

Tetrodotoxin-sensitive voltage-gated sodium channels regulate bladder afferent responses to distension

(2018) Luke Grundy et al.   PAIN

Mechanisms Underlying Overactive Bladder and Interstitial Cystitis/Painful Bladder Syndrome

(2018) Luke Grundy et al.   Frontiers in Neuroscience

Mechanisms of the adenosine A2A receptor-induced sensitization of esophageal C fibers

(2016) M. Brozmanova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs

(2016) Gemma Navarro et al.   BMC BIOLOGY

The Role Played by Adenosine in Modulating Reflex Sympathetic and Pressor Responses Evoked by Stimulation of TRPV1 in Muscle Afferents

(2016) Jihong Xing et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Participation of pro- and anti-nociceptive interleukins in botulinum toxin A-induced analgesia in a rat model of neuropathic pain

(2016) Magdalena Zychowska et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

How does adenosine control neuronal dysfunction and neurodegeneration?

(2016) Rodrigo A. Cunha   JOURNAL OF NEUROCHEMISTRY

Omega-3 fatty acids are able to modulate the painful symptoms associated to cyclophosphamide-induced-hemorrhagic cystitis in mice

(2016) Raquel D.S. Freitas et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Spinal astrocytic activation contributes to mechanical allodynia in a rat model of cyclophosphamide-induced cystitis

(2016) Bolong Liu et al.   Molecular Pain

Adenosine receptor targets for pain

(2016) J. Sawynok   NEUROSCIENCE

Serotonin (5-HT)2A/2C receptor agonist (2,5-dimethoxy-4-idophenyl)-2-aminopropane hydrochloride (DOI) improves voiding efficiency in the diabetic rat

(2015) Hongjian Tu et al.   BJU INTERNATIONAL

Are Mast Cells Still Good Biomarkers for Bladder Pain Syndrome/Interstitial Cystitis?

(2015) Marianne Gamper et al.   JOURNAL OF UROLOGY

Bladder sensory physiology: neuroactive compounds and receptors, sensory transducers, and target-derived growth factors as targets to improve function

(2014) Eric J. Gonzalez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Bladder afferent hyperexcitability in bladder pain syndrome/interstitial cystitis

(2014) Naoki Yoshimura et al.   INTERNATIONAL JOURNAL OF UROLOGY

Evidence for Bladder Urothelial Pathophysiology in Functional Bladder Disorders

(2014) Susan K. Keay et al.   Biomed Research International

Cyclophosphamide-induced cystitis reduces ASIC channel but enhances TRPV1 receptor function in rat bladder sensory neurons

(2013) Khoa Dang et al.   JOURNAL OF NEUROPHYSIOLOGY

Brain-derived neurotrophic factor, acting at the spinal cord level, participates in bladder hyperactivity and referred pain during chronic bladder inflammation

(2013) B. Frias et al.   NEUROSCIENCE

Roles of adenosine A1 and A2A receptors in the control of micturition in rats

(2013) Takeya Kitta et al.   NEUROUROLOGY AND URODYNAMICS

Intravesical Resiniferatoxin for the Treatment of Storage Lower Urinary Tract Symptoms in Patients with Either Interstitial Cystitis or Detrusor Overactivity: A Meta-Analysis

(2013) Changcheng Guo et al.   PLoS One

In Vivo Regulation of Brain-Derived Neurotrophic Factor in Dorsal Root Ganglia Is Mediated by Nerve Growth Factor-Triggered Akt Activation during Cystitis

(2013) Li-Ya Qiao et al.   PLoS One

Intravesical treatment of painful bladder syndrome: a systematic review and meta-analysis

(2012) P. K. Matsuoka et al.   INTERNATIONAL UROGYNECOLOGY JOURNAL

Suppression of Bladder Overactivity by Adenosine A2A Receptor Antagonist in a Rat Model of Parkinson Disease

(2012) Takeya Kitta et al.   JOURNAL OF UROLOGY

Adenosine-induced activation of esophageal nociceptors

(2010) F. Ru et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Gating of Sensory Information Differs in Patients With Interstitial Cystitis/Painful Bladder Syndrome

(2010) Lisa Ann Kilpatrick et al.   JOURNAL OF UROLOGY

Genetic deletion of the adenosine A2A receptor in mice reduces the changes in spinal cord NMDA receptor binding and glucose uptake caused by a nociceptive stimulus

(2010) M.J. Hussey et al.   NEUROSCIENCE LETTERS

Direct blockade of inflammatory hypernociception by peripheral A1 adenosine receptors: Involvement of the NO/cGMP/PKG/KATP signaling pathway

(2010) Flávia Oliveira Lima et al.   PAIN

Role of mast cells and protease-activated receptor-2 in cyclooxygenase-2 expression in urothelial cells

(2009) Zun-Yi Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Phosphorylation of extracellular signal-regulated kinases in bladder afferent pathways with cyclophosphamide-induced cystitis

(2009) K.A. Corrow et al.   NEUROSCIENCE

Rapid, Opioid-sensitive Mechanisms Involved in Transient Receptor Potential Vanilloid 1 Sensitization

(2008) Irina Vetter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteine-Rich Protein 2, a Novel Downstream Effector of cGMP/cGMP-Dependent Protein Kinase I-Mediated Persistent Inflammatory Pain

(2008) A. Schmidtko et al.   JOURNAL OF NEUROSCIENCE

GRC-6211, a New Oral Specific TRPV1 Antagonist, Decreases Bladder Overactivity and Noxious Bladder Input in Cystitis Animal Models

(2008) Ana Charrua et al.   JOURNAL OF UROLOGY

Lack of TRPV1 inhibits cystitis-induced increased mechanical sensitivity in mice

(2008) Zun-Yi Wang et al.   PAIN

A2A adenosine receptor regulates glia proliferation and pain after peripheral nerve injury

(2008) Andreea S. Bura et al.   PAIN

Regulation of enteric functions by adenosine: Pathophysiological and pharmacological implications

(2008) Luca Antonioli et al.   PHARMACOLOGY & THERAPEUTICS

Cyclophosphamide-Induced Bladder Inflammation Sensitizes and Enhances P2X Receptor Function in Rat Bladder Sensory Neurons

(2007) Khoa Dang et al.   JOURNAL OF NEUROPHYSIOLOGY

Adenosine in the central nervous system: release mechanisms and extracellular concentrations

(2003) Serena Latini et al.   JOURNAL OF NEUROCHEMISTRY