Interstitial cystitis/bladder pain syndrome: The evolving landscape, animal models and future perspectives

Molecular Taxonomy of Interstitial Cystitis/Bladder Pain Syndrome Based on Whole Transcriptome Profiling by Next-Generation RNA Sequencing of Bladder Mucosal Biopsies

(2019) Yoshiyuki Akiyama et al.   JOURNAL OF UROLOGY

Targeting the SHIP1 Pathway fails to show treatment benefit in Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS): Lessons learned from evaluating potentially effective therapies in this enigmatic syndrome

(2019) J. Curtis Nickel et al.   JOURNAL OF UROLOGY

Phenotyping of interstitial cystitis/bladder pain syndrome

(2019) Yoshiyuki Akiyama et al.   INTERNATIONAL JOURNAL OF UROLOGY

Hunner lesion versus non‐Hunner lesion interstitial cystitis/bladder pain syndrome

(2019) Kristene E Whitmore et al.   INTERNATIONAL JOURNAL OF UROLOGY

Risks of interstitial cystitis among patients with systemic lupus erythematosus: A population‐based cohort study

(2019) Jen‐Yu Wen et al.   INTERNATIONAL JOURNAL OF UROLOGY

Effect of Water Avoidance Stress on serum and urinary NGF levels in rats: diagnostic and therapeutic implications for BPS/IC patients

(2019) Bruno Dias et al.   Scientific Reports

Epstein-Barr Virus as a Potential Etiology of Persistent Bladder Inflammation in Human Interstitial Cystitis/Bladder Pain Syndrome

(2018) Jia-Fong Jhang et al.   JOURNAL OF UROLOGY

Electron microscopic characteristics of interstitial cystitis/bladder pain syndrome and their association with clinical condition

(2018) Jia-Fong Jhang et al.   PLoS One

Translocation of a gut pathobiont drives autoimmunity in mice and humans

(2018) S. Manfredo Vieira et al.   SCIENCE

Endoscopic Injection of Low Dose Triamcinolone: A Simple, Minimally Invasive, and Effective Therapy for Interstitial Cystitis With Hunner Lesions

(2018) Michael G. Funaro et al.   UROLOGY

Sub-noxious Intravesical Lipopolysaccharide Triggers Bladder Inflammation and Symptom Onset in A Transgenic Autoimmune Cystitis Model: A MAPP Network Animal Study

(2018) Paul Kogan et al.   Scientific Reports

The Effects of Neurokinin-1 Receptor Antagonist in an Experimental Autoimmune Cystitis Model Resembling Bladder Pain Syndrome/Interstitial Cystitis

(2018) Bo-Ke Liu et al.   INFLAMMATION

Comparison of urologic and non-urologic presentation in interstitial cystitis/bladder pain syndrome patients with and without Hunner lesions

(2018) Frederick Van Moh et al.   NEUROUROLOGY AND URODYNAMICS

Stress-induced autonomic dysregulation of mitochondrial function in the rat urothelium

(2018) Florenta Aura Kullmann et al.   NEUROUROLOGY AND URODYNAMICS

Histopathological characteristics of interstitial cystitis/bladder pain syndrome without Hunner lesion

(2017) Aram Kim et al.   HISTOPATHOLOGY

An Immunogenic Peptide, T2 Induces Interstitial Cystitis/Painful Bladder Syndrome: an Autoimmune Mouse Model for Interstitial Cystitis/Painful Bladder Syndrome

(2017) Li Zhang et al.   INFLAMMATION

Establishment of a Novel Autoimmune Experimental Model of Bladder Pain Syndrome/Interstitial Cystitis in C57BL/6 Mice

(2017) Xing-Wei Jin et al.   INFLAMMATION

Somatic symptoms are sensitive in predicting interstitial cystitis/bladder pain syndrome

(2017) I-Chun Chen et al.   INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE

Alexithymia and anesthetic bladder capacity in interstitial cystitis/bladder pain syndrome

(2017) Chui-De Chiu et al.   JOURNAL OF PSYCHOSOMATIC RESEARCH

Somatoform disorder as a predictor of interstitial cystitis/bladder pain syndrome

(2017) I-Chun Chen et al.   MEDICINE

The water avoidance stress induces bladder pain due to a prolonged alpha1A adrenoceptor stimulation

(2017) Rita Matos et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The role of C-fibers in the development of chronic psychological stress induced enhanced bladder sensations and nociceptive responses: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome (MAPP) research network study

(2017) Yunliang Gao et al.   NEUROUROLOGY AND URODYNAMICS

Digital quantitative analysis of mast cell infiltration in interstitial cystitis

(2017) Yoshiyuki Akiyama et al.   NEUROUROLOGY AND URODYNAMICS

Urinary Microbiome and Cytokine Levels in Women With Interstitial Cystitis

(2017) Melinda G. Abernethy et al.   OBSTETRICS AND GYNECOLOGY

Brain signature and functional impact of centralized pain

(2017) Jason J. Kutch et al.   PAIN

Effects of water avoidance stress on peripheral and central responses during bladder filling in the rat: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome (MAPP) research network study

(2017) Zhuo Wang et al.   PLoS One

Urinary bladder hypersensitivity and dysfunction in female mice following early life and adult stress

(2016) Angela N. Pierce et al.   BRAIN RESEARCH

Clinical guidelines for interstitial cystitis and hypersensitive bladder updated in 2015

(2016) Yukio Homma et al.   INTERNATIONAL JOURNAL OF UROLOGY

The Role of Glomerulations in Bladder Pain Syndrome: A Review

(2016) Gjertrud E. Wennevik et al.   JOURNAL OF UROLOGY

Clinical Phenotyping Does Not Differentiate Hunner Lesion Subtype of Interstitial Cystitis/Bladder Pain Syndrome: A Relook at the Role of Cystoscopy

(2016) R. Christopher Doiron et al.   JOURNAL OF UROLOGY

Increased CXCR3 Expression of Infiltrating Plasma Cells in Hunner Type Interstitial Cystitis

(2016) Yoshiyuki Akiyama et al.   Scientific Reports

Toll-like Receptor 4 and comorbid pain in Interstitial Cystitis/Bladder Pain Syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain research network study

(2015) Andrew Schrepf et al.   BRAIN BEHAVIOR AND IMMUNITY

Possible pathophysiology of ketamine-related cystitis and associated treatment strategies

(2015) Jia-Fong Jhang et al.   INTERNATIONAL JOURNAL OF UROLOGY

The common link between functional somatic syndromes may be central sensitisation

(2015) Julius H. Bourke et al.   JOURNAL OF PSYCHOSOMATIC RESEARCH

Are Mast Cells Still Good Biomarkers for Bladder Pain Syndrome/Interstitial Cystitis?

(2015) Marianne Gamper et al.   JOURNAL OF UROLOGY

Diagnosis and Treatment of Interstitial Cystitis/Bladder Pain Syndrome: AUA Guideline Amendment

(2015) Philip M. Hanno et al.   JOURNAL OF UROLOGY

Chronic psychological stress in high-anxiety rats induces sustained bladder hyperalgesia

(2015) Una J. Lee et al.   PHYSIOLOGY & BEHAVIOR

Evasion of affinity-based selection in germinal centers by Epstein–Barr virus LMP2A

(2015) Takeharu Minamitani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electrosurgical Management of Hunner Ulcers in a Referral Center's Interstitial Cystitis Population

(2015) Avinash Chennamsetty et al.   UROLOGY

Hunner-Type (Classic) Interstitial Cystitis: A Distinct Inflammatory Disorder Characterized by Pancystitis, with Frequent Expansion of Clonal B-Cells and Epithelial Denudation

(2015) Daichi Maeda et al.   PLoS One

Inflammation characteristics in bladder pain syndrome ESSIC type 3C/classic interstitial cystitis

(2014) Yr Logadottir et al.   INTERNATIONAL JOURNAL OF UROLOGY

Bladder pain syndrome/interstitial cystitis as a functional somatic syndrome

(2014) John W. Warren   JOURNAL OF PSYCHOSOMATIC RESEARCH

Ulcerative and Nonulcerative Forms of Bladder Pain Syndrome/Interstitial Cystitis Do Not Differ in Symptom Intensity or Response to Onabotulinum Toxin A

(2014) Rui Pinto et al.   UROLOGY

Role ofHelicobacter pyloriin gastric mucosa-associated lymphoid tissue lymphomas

(2014) Marta-Isabel Pereira   WORLD JOURNAL OF GASTROENTEROLOGY

Alteration of Urothelial Inflammation, Apoptosis, and Junction Protein in Patients with Various Bladder Conditions and Storage Bladder Symptoms Suggest Common Pathway Involved in Underlying Pathophysiology

(2014) Hsin-Tzu LIU et al.   LUTS-Lower Urinary Tract Symptoms

Biological phenotypes underpin the physio-somatic symptoms of somatization, depression, and chronic fatigue syndrome

(2013) G. Anderson et al.   ACTA PSYCHIATRICA SCANDINAVICA

Role of urinary cations in the aetiology of bladder symptoms and interstitial cystitis

(2013) C. Lowell Parsons et al.   BJU INTERNATIONAL

Increased mRNA Expression of Genes Involved in Pronociceptive Inflammatory Reactions in Bladder Tissue of Interstitial Cystitis

(2013) Yukio Homma et al.   JOURNAL OF UROLOGY

Increased Urothelial Cell Apoptosis and Chronic Inflammation Are Associated with Recurrent Urinary Tract Infection in Women

(2013) Fei-Chi Chuang et al.   PLoS One

Uroplakin Peptide-Specific Autoimmunity Initiates Interstitial Cystitis/Painful Bladder Syndrome in Mice

(2013) Kenan Izgi et al.   PLoS One

The Severity of Experimental Autoimmune Cystitis Can be Ameliorated by Anti-CXCL10 Ab Treatment

(2013) Udai P. Singh et al.   PLoS One

Diet and its role in interstitial cystitis/bladder pain syndrome (IC/BPS) and comorbid conditions

(2012) Justin I. Friedlander et al.   BJU INTERNATIONAL

Alterations of microbiota in urine from women with interstitial cystitis

(2012) Huma Siddiqui et al.   BMC MICROBIOLOGY

Fulguration for Hunner Ulcers: Long-Term Clinical Outcomes

(2012) Joel H. Hillelsohn et al.   JOURNAL OF UROLOGY

The Distribution and Function of Chondroitin Sulfate and Other Sulfated Glycosaminoglycans in the Human Bladder and Their Contribution to the Protective Bladder Barrier

(2012) Dick A.W. Janssen et al.   JOURNAL OF UROLOGY

Mast cells: an expanding pathophysiological role from allergy to other disorders

(2012) Preet Anand et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Infection and autoimmune disease

(2012) Asli Gamze Sener et al.   RHEUMATOLOGY INTERNATIONAL

Clinical characteristics differ considerably between phenotypes of bladder pain syndrome/interstitial cystitis

(2012) Yr Logadottir et al.   SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY

Differences in Mast Cell Infiltration, E-cadherin, and Zonula Occludens-1 Expression Between Patients With Overactive Bladder and Interstitial Cystitis/Bladder Pain Syndrome

(2012) Hsin-Tzu Liu et al.   UROLOGY

BALB/c-Fcgr2b−/−Pdcd1−/− mouse expressing anti-urothelial antibody is a novel model of autoimmune cystitis

(2012) Yoshio Sugino et al.   Scientific Reports

Autoimmunity to Uroplakin II Causes Cystitis in Mice: A Novel Model of Interstitial Cystitis

(2011) Cengiz Z. Altuntas et al.   EUROPEAN UROLOGY

Urothelial antigen-specific CD4+ T cells function as direct effector cells and induce bladder autoimmune inflammation independent of CD8+ T cells

(2011) W Liu et al.   Mucosal Immunology

Models of inflammation of the lower urinary tract

(2011) Dale E. Bjorling et al.   NEUROUROLOGY AND URODYNAMICS

Increased Expression of Hypoxia-inducible Factor-1α and Vascular Endothelial Growth Factor Associated With Glomerulation Formation in Patients With Interstitial Cystitis

(2011) Jane-Dar Lee et al.   UROLOGY

Are Ulcerative and Nonulcerative Interstitial Cystitis/Painful Bladder Syndrome 2 Distinct Diseases? A Study of Coexisting Conditions

(2011) Kenneth M. Peters et al.   UROLOGY

Dietary Consumption Triggers in Interstitial Cystitis/Bladder Pain Syndrome Patients

(2011) Renee Bassaly et al.   Female Pelvic Medicine and Reconstructive Surgery

Diet restriction in migraine, based on IgG against foods: A clinical double-blind, randomised, cross-over trial

(2010) Kadriye Alpay et al.   CEPHALALGIA

YKL-40 and mast cells are associated with detrusor fibrosis in patients diagnosed with bladder pain syndrome/interstitial cystitis according to the 2008 criteria of the European Society for the Study of Interstitial Cystitis

(2010) Benedikte Richter et al.   HISTOPATHOLOGY

Intravesical Dimethyl Sulfoxide Inhibits Acute and Chronic Bladder Inflammation in Transgenic Experimental Autoimmune Cystitis Models

(2010) Ronald Kim et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Fibromyalgia and nutrition, what do we know?

(2010) Laura-Isabel Arranz et al.   RHEUMATOLOGY INTERNATIONAL

Increased vascular endothelial growth factor expression in patients with bladder pain syndrome/interstitial cystitis: its association with pain severity and glomerulations

(2009) Hiroshi Kiuchi et al.   BJU INTERNATIONAL

The Role of Diet in Symptoms of Irritable Bowel Syndrome in Adults: A Narrative Review

(2009) William D. Heizer et al.   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION

Cross-talk and sensitization of bladder afferent nerves

(2009) Elena E. Ustinova et al.   NEUROUROLOGY AND URODYNAMICS

Potential Dietary Links to Central Sensitization in Fibromyalgia: Past Reports and Future Directions

(2009) Kathleen F. Holton et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Lower urinary tract phenotype of experimental autoimmune cystitis in mouse: a potential animal model for interstitial cystitis

(2008) Yi-Hao Lin et al.   BJU INTERNATIONAL

The concept of neurogenic inflammation

(2008) Pierangelo Geppetti et al.   BJU INTERNATIONAL

Quantifying mast cells in bladder pain syndrome by immunohistochemical analysis

(2008) Mathilde S. Larsen et al.   BJU INTERNATIONAL

RDP58 inhibits T cell-mediated bladder inflammation in an autoimmune cystitis model

(2008) Wujiang Liu et al.   JOURNAL OF AUTOIMMUNITY

Antecedent Nonbladder Syndromes in Case-Control Study of Interstitial Cystitis/Painful Bladder Syndrome

(2008) John W. Warren et al.   UROLOGY

Diagnostic Criteria, Classification, and Nomenclature for Painful Bladder Syndrome/Interstitial Cystitis: An ESSIC Proposal

(2007) Joop P. van de Merwe et al.   EUROPEAN UROLOGY