Molecular mechanism of agonism and inverse agonism in ghrelin receptor
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Molecular mechanism of agonism and inverse agonism in ghrelin receptor
Authors
Keywords
-
Journal
Nature Communications
Volume 13, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-01-18
DOI
10.1038/s41467-022-27975-9
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex
- (2021) Yu-Qi Ping et al. NATURE
- Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes
- (2021) Peng Xiao et al. CELL
- Structural basis of ligand recognition and self-activation of orphan GPR52
- (2020) Xi Lin et al. NATURE
- Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor
- (2020) Kuglae Kim et al. CELL
- UCSF ChimeraX : Structure visualization for researchers, educators, and developers
- (2020) Eric F. Pettersen et al. PROTEIN SCIENCE
- Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode
- (2020) Yuki Shiimura et al. Nature Communications
- Crystal Structure of the Human Cannabinoid Receptor CB2
- (2019) Xiaoting Li et al. CELL
- Illuminating G-Protein-Coupling Selectivity of GPCRs
- (2019) Asuka Inoue et al. CELL
- Conformational transitions of a neurotensin receptor 1–Gi1 complex
- (2019) Hideaki E. Kato et al. NATURE
- Structure and dynamics of G protein-coupled receptor–bound ghrelin reveal the critical role of the octanoyl chain
- (2019) Guillaume Ferré et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hunger, ghrelin and the gut
- (2018) Jon Davis BRAIN RESEARCH
- 5-HT 2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology
- (2018) Yao Peng et al. CELL
- The Homeostatic Force of Ghrelin
- (2018) Shigehisa Yanagi et al. Cell Metabolism
- Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone
- (2018) Sheng Wang et al. NATURE
- N-Terminal Liver-Expressed Antimicrobial Peptide 2 (LEAP2) Region Exhibits Inverse Agonist Activity toward the Ghrelin Receptor
- (2018) Céline M’Kadmi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Therapeutic Potential of Targeting the Ghrelin Pathway
- (2017) Gustav Colldén et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Crystal structures of agonist-bound human cannabinoid receptor CB1
- (2017) Tian Hua et al. NATURE
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- Guidelines for using Bsoft for high resolution reconstruction and validation of biomolecular structures from electron micrographs
- (2017) J. Bernard Heymann PROTEIN SCIENCE
- UCSF ChimeraX: Meeting modern challenges in visualization and analysis
- (2017) Thomas D. Goddard et al. PROTEIN SCIENCE
- Pharmacokinetics and pharmacodynamics of PF-05190457: The first oral ghrelin receptor inverse agonist to be profiled in healthy subjects
- (2016) William S. Denney et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Pharmacological characterization of the first in class clinical candidate PF-05190457: a selective ghrelin receptor competitive antagonist with inverse agonism that increases vagal afferent firing and glucose-dependent insulin secretionex vivo
- (2016) J Kong et al. BRITISH JOURNAL OF PHARMACOLOGY
- Gctf: Real-time CTF determination and correction
- (2016) Kai Zhang JOURNAL OF STRUCTURAL BIOLOGY
- High-resolution crystal structure of the human CB1 cannabinoid receptor
- (2016) Zhenhua Shao et al. NATURE
- Structural prerequisites for G-protein activation by the neurotensin receptor
- (2015) Brian E. Krumm et al. Nature Communications
- Integrating Solid-State NMR and Computational Modeling to Investigate the Structure and Dynamics of Membrane-Associated Ghrelin
- (2015) Gerrit Vortmeier et al. PLoS One
- G Protein and β-Arrestin Signaling Bias at the Ghrelin Receptor
- (2014) Tama Evron et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate
- (2014) Samit K. Bhattacharya et al. ACS Medicinal Chemistry Letters
- Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody
- (2013) Aaron M. Ring et al. NATURE
- Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor
- (2012) Daniel W. Kung et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance
- (2012) Joseph Tam et al. Cell Metabolism
- Acylation Type Determines Ghrelin's Effects on Energy Homeostasis in Rodents
- (2012) Kristy M. Heppner et al. ENDOCRINOLOGY
- Morphine Withdrawal Enhances Constitutive -Opioid Receptor Activity in the Ventral Tegmental Area
- (2012) F. J. Meye et al. JOURNAL OF NEUROSCIENCE
- RELION: Implementation of a Bayesian approach to cryo-EM structure determination
- (2012) Sjors H.W. Scheres JOURNAL OF STRUCTURAL BIOLOGY
- Crystal Structure of a Lipid G Protein-Coupled Receptor
- (2012) M. A. Hanson et al. SCIENCE
- Lipidic cubic phase technologies for membrane protein structural studies
- (2011) Vadim Cherezov CURRENT OPINION IN STRUCTURAL BIOLOGY
- High Constitutive Activity Is an Intrinsic Feature of Ghrelin Receptor Protein
- (2011) Marjorie Damian et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- XDS
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Ghrelin: more than endogenous growth hormone secretagogue
- (2010) Masayasu Kojima et al. Annals of the New York Academy of Sciences
- Ghrelin O-acyltransferase (GOAT) has a preference for n-hexanoyl-CoA over n-octanoyl-CoA as an acyl donor
- (2009) Hideko Ohgusu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- An Acyl-Ghrelin-Specific Neutralizing Antibody Inhibits the Acute Ghrelin-Mediated Orexigenic Effects in Mice
- (2009) S.-C. Lu et al. MOLECULAR PHARMACOLOGY
- Crystallizing membrane proteins using lipidic mesophases
- (2009) Martin Caffrey et al. Nature Protocols
- Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone
- (2008) Jing Yang et al. CELL
- Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides
- (2008) J. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ghrelin octanoylation mediated by an orphan lipid transferase
- (2008) J. A. Gutierrez et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Characterization of Adult Ghrelin and Ghrelin Receptor Knockout Mice under Positive and Negative Energy Balance
- (2007) Yuxiang Sun et al. ENDOCRINOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now