Therapeutic Potential of Targeting the Ghrelin Pathway

Acyl Ghrelin Induces Insulin Resistance Independently of GH, Cortisol and Free Fatty Acids

(2017) Esben T. Vestergaard et al.   Scientific Reports

The ghrelin receptor agonist HM01 mimics the neuronal effects of ghrelin in the arcuate nucleus and attenuates anorexia-cachexia syndrome in tumor-bearing rats

(2016) Tito Borner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

(2016) Brian Finan et al.   CELL

Unacylated Ghrelin Reduces Skeletal Muscle Reactive Oxygen Species Generation and Inflammation and Prevents High-Fat Diet–Induced Hyperglycemia and Whole-Body Insulin Resistance in Rodents

(2016) Gianluca Gortan Cappellari et al.   DIABETES

Neuronal Deletion of Ghrelin Receptor Almost Completely Prevents Diet-Induced Obesity

(2016) Jong Han Lee et al.   DIABETES

Relamorelin Reduces Vomiting Frequency and Severity and Accelerates Gastric Emptying in Adults With Diabetic Gastroparesis

(2016) Anthony Lembo et al.   GASTROENTEROLOGY

Ghrelin-AMPK Signaling Mediates the Neuroprotective Effects of Calorie Restriction in Parkinson's Disease

(2016) J. A. Bayliss et al.   JOURNAL OF NEUROSCIENCE

Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials

(2016) Jennifer S Temel et al.   LANCET ONCOLOGY

Ghrelin and Neurodegenerative Disorders—a Review

(2016) Limin Shi et al.   MOLECULAR NEUROBIOLOGY

Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1

(2016) N Fujitsuka et al.   MOLECULAR PSYCHIATRY

Ghrelin modulates encoding-related brain function without enhancing memory formation in humans

(2016) N. Kunath et al.   NEUROIMAGE

Ghrelin protects MES23.5 cells against rotenone via inhibiting mitochondrial dysfunction and apoptosis

(2016) Jianhan Yu et al.   NEUROPEPTIDES

High unacylated ghrelin levels support the concept of anorexia in infants with prader-willi syndrome

(2016) Veronique Beauloye et al.   Orphanet Journal of Rare Diseases

Anamorelin (ONO-7643) in Japanese patients with non-small cell lung cancer and cachexia: results of a randomized phase 2 trial

(2016) Koichi Takayama et al.   SUPPORTIVE CARE IN CANCER

A low-salt diet increases the expression of renal sirtuin 1 through activation of the ghrelin receptor in rats

(2016) Shao-Yu Yang et al.   Scientific Reports

Randomized Phase II Study of the Anti-inflammatory Effect of Ghrelin During the Postoperative Period of Esophagectomy

(2015) Akihiro Takata et al.   ANNALS OF SURGERY

Randomized, dose-finding trial of ghrelin treatment for chronic respiratory failure

(2015) Keisuke Miki et al.   Clinical Respiratory Journal

Ghrelin Inhibition Restores Glucose Homeostasis in Hepatocyte Nuclear Factor-1α (MODY3)–Deficient Mice

(2015) François Brial et al.   DIABETES

Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice

(2015) C. Clemmensen et al.   EMBO Molecular Medicine

Ghrelin Protects Alveolar Macrophages Against Lipopolysaccharide-Induced Apoptosis Through Growth Hormone Secretagogue Receptor 1a-Dependent c-Jun N-Terminal Kinase and Wnt/β-Catenin Signaling and Suppresses Lung Inflammation

(2015) Bin Li et al.   ENDOCRINOLOGY

Ghrelin ameliorates catabolic conditions and respiratory dysfunction in a chronic obstructive pulmonary disease model of chronic cigarette smoke-exposed rats

(2015) Yoshiyuki Kamiide et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neutralizing circulating ghrelin by expressing a growth hormone secretagogue receptor-based protein protects against high-fat diet-induced obesity in mice

(2015) J Gagnon et al.   GENE THERAPY

Ghrelin Inhibits Interleukin-6 Production Induced by Cigarette Smoke Extract in the Bronchial Epithelial Cell Via NF-κB Pathway

(2015) Hao Wang et al.   INFLAMMATION

GhrelinO-acyltransferase knockout mice show resistance to obesity when fed high-sucrose diet

(2015) Tetsuya Kouno et al.   JOURNAL OF ENDOCRINOLOGY

Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation

(2015) Farhana Naznin et al.   JOURNAL OF ENDOCRINOLOGY

Relationship between plasma ghrelin levels and sarcopenia in elderly subjects: A cross-sectional study

(2015) Mateu Serra-Prat et al.   Journal of Nutrition Health & Aging

Effects of ghrelin treatment on exertional dyspnea in COPD: an exploratory analysis

(2015) Keisuke Miki et al.   Journal of Physiological Sciences

Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosis

(2015) S.T. Ngo et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Ghrelin Attenuates Renal Fibrosis and Inflammation of Obstructive Nephropathy

(2015) Guang-Xi Sun et al.   JOURNAL OF UROLOGY

Anamorelin for patients with cancer cachexia: an integrated analysis of two phase 2, randomised, placebo-controlled, double-blind trials

(2015) José M Garcia et al.   LANCET ONCOLOGY

Ghrelin Administration for Chronic Respiratory Failure: A Randomized Dose-Comparison Trial

(2015) Nobuhiro Matsumoto et al.   LUNG

Ghrelin signaling in the ventral tegmental area mediates both reward-based feeding and fasting-induced hyperphagia on high-fat diet

(2015) X.J. Wei et al.   NEUROSCIENCE

Central acylated ghrelin improves memory function and hippocampal AMPK activation and partly reverses the impairment of energy and glucose metabolism in rats infused with β-amyloid

(2015) Suna Kang et al.   PEPTIDES

The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation

(2015) Brianne A. Kent et al.   PSYCHONEUROENDOCRINOLOGY

Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimer’s disease mouse model

(2015) Nicolas Kunath et al.   Scientific Reports

The role of the SenseWear device and ghrelin for metabolism in amyotrophic lateral sclerosis

(2015) David Czell et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

One-year intranasal application of growth hormone releasing peptide-2 improves body weight and hypoglycemia in a severely emaciated anorexia nervosa patient

(2015) Izumi Haruta et al.   Journal of Cachexia Sarcopenia and Muscle

Ghrelin prevents tumour- and cisplatin-induced muscle wasting: characterization of multiple mechanisms involved

(2015) Ji-an Chen et al.   Journal of Cachexia Sarcopenia and Muscle

Ghrelin

(2015) T.D. Müller et al.   Molecular Metabolism

Effect of Ghrelin on Mortality and Cardiovascular Outcomes in Experimental Rat and Mice Models of Heart Failure: A Systematic Review and Meta-Analysis

(2015) Mahalaqua Nazli Khatib et al.   PLoS One

Hyperghrelinemia in Prader-Willi syndrome begins in early infancy long before the onset of hyperphagia

(2014) Frederick A. Kweh et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Induced Ablation of Ghrelin Cells in Adult Mice Does Not Decrease Food Intake, Body Weight, or Response to High-Fat Diet

(2014) Matthew R. McFarlane et al.   Cell Metabolism

Effects of ghrelin on sepsis-induced acute kidney injury: one step forward

(2014) Akef Khowailed et al.   Clinical and Experimental Nephrology

Ghrelin relieves cancer cachexia associated with the development of lung adenocarcinoma in mice

(2014) Hironobu Tsubouchi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ghrelin Attenuates Sepsis-Associated Acute Lung Injury Oxidative Stress in Rats

(2014) Mian Zeng et al.   INFLAMMATION

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

(2014) Brian Finan et al.   NATURE MEDICINE

New ghrelin agonist, HM01 alleviates constipation and L-dopa-delayed gastric emptying in 6-hydroxydopamine rat model of Parkinson's disease

(2014) H. Karasawa et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexia syndrome: preclinical profile

(2014) Claudio Pietra et al.   Journal of Cachexia Sarcopenia and Muscle

Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults

(2013) Ralf Nass et al.   ANNALS OF INTERNAL MEDICINE

Therapeutic effect of ghrelin in experimental autoimmune encephalomyelitis by inhibiting antigen-specific Th1/Th17 responses and inducing regulatory T cells

(2013) Luciana Souza-Moreira et al.   BRAIN BEHAVIOR AND IMMUNITY

Immunization Against Active Ghrelin Using Virus-Like Particles for Obesity Treatment

(2013) Sara Andrade et al.   CURRENT PHARMACEUTICAL DESIGN

Ghrelin as a Neuroprotective and Palliative Agent in Alzheimer's and Parkinson's Disease

(2013) Vanessa V. dos Santos et al.   CURRENT PHARMACEUTICAL DESIGN

Does des-acyl ghrelin improve glycemic control in obese diabetic subjects by decreasing acylated ghrelin levels?

(2013) Behiye Özcan et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Serum ghrelin and adiponectin levels are increased but serum leptin level is unchanged in low weight Chronic Obstructive Pulmonary Disease patients

(2013) Ayse Kubat Uzum et al.   European Journal of Internal Medicine

Age-Dependent Decline in Acyl-Ghrelin Concentrations and Reduced Association of Acyl-Ghrelin and Growth Hormone in Healthy Older Adults

(2013) Ralf Nass et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Plasma Ghrelin Levels and Weight Loss in Chinese Uygur Patients with Chronic Obstructive Pulmonary Disease

(2013) BW Ying et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Ghrelin inhibits LPS-induced release of IL-6 from mouse dopaminergic neurones

(2013) Amy L Beynon et al.   Journal of Neuroinflammation

Delayed gastric emptying in Parkinson's disease

(2013) Sarah Marrinan et al.   MOVEMENT DISORDERS

Ghrelin increases vagally mediated gastric activity by central sites of action

(2013) E. M. Swartz et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Divergent circuitry underlying food reward and intake effects of ghrelin: Dopaminergic VTA-accumbens projection mediates ghrelin's effect on food reward but not food intake

(2013) Karolina P. Skibicka et al.   NEUROPHARMACOLOGY

Acylated ghrelin limits fat accumulation and improves redox state and inflammation markers in the liver of high-fat-fed rats

(2013) Rocco Barazzoni et al.   Obesity

Chronic central ghrelin infusion reduces blood pressure and heart rate despite increasing appetite and promoting weight gain in normotensive and hypertensive rats

(2013) John N. Freeman et al.   PEPTIDES

Ghrelin protects human pulmonary artery endothelial cells against hypoxia-induced injury via PI3-kinase/Akt

(2013) Dan Yang et al.   PEPTIDES

Ghrelin protects heart against ERS-induced injury and apoptosis by activating AMP-activated protein kinase

(2013) Gai-Gai Zhang et al.   PEPTIDES

Hunger in the Absence of Caloric Restriction Improves Cognition and Attenuates Alzheimer's Disease Pathology in a Mouse Model

(2013) Emily J. Dhurandhar et al.   PLoS One

The Role of the Vagus Nerve in the Migrating Motor Complex and Ghrelin- and Motilin-Induced Gastric Contraction in Suncus

(2013) Yuki Miyano et al.   PLoS One

Chronic Central Administration of Ghrelin Increases Bone Mass through a Mechanism Independent of Appetite Regulation

(2013) Hyung Jin Choi et al.   PLoS One

Relation of Leptin, Ghrelin and Inflammatory Cytokines with Body Mass Index in Pulmonary Tuberculosis Patients with and without Type 2 Diabetes Mellitus

(2013) Ying Zheng et al.   PLoS One

Effect of ghrelin and anamorelin (ONO-7643), a selective ghrelin receptor agonist, on tumor growth in a lung cancer mouse xenograft model

(2013) R. Northrup et al.   SUPPORTIVE CARE IN CANCER

Effects of Ghrelin Treatment on Exercise Capacity in Underweight COPD Patients: a substudy of a multicenter, randomized, double-blind, placebo-controlled trial of ghrelin treatment

(2013) Keisuke Miki et al.   BMC Pulmonary Medicine

Impaired ghrelin signaling is associated with gastrointestinal dysmotility in rats with gastroesophageal reflux disease

(2012) Miwa Nahata et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Ghrelin Regulates the Hypothalamic-Pituitary-Adrenal Axis and Restricts Anxiety After Acute Stress

(2012) Sarah J. Spencer et al.   BIOLOGICAL PSYCHIATRY

Ghrelin Signaling in the Ventral Hippocampus Stimulates Learned and Motivational Aspects of Feeding via PI3K-Akt Signaling

(2012) Scott E. Kanoski et al.   BIOLOGICAL PSYCHIATRY

Randomized Controlled Phase Ib Study of Ghrelin Agonist, RM-131, in Type 2 Diabetic Women With Delayed Gastric Emptying: Pharmacokinetics and pharmacodynamics

(2012) A. Shin et al.   DIABETES CARE

Effects of ghrelin on pulmonary NOD2 mRNA expression and NF-κB activation when protects against acute lung injury in rats challenged with cecal ligation and puncture

(2012) Zhiyou Peng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ghrelin Protects H9c2 Cardiomyocytes From Angiotensin II–induced Apoptosis Through the Endoplasmic Reticulum Stress Pathway

(2012) Chunyan Yang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Effect of ghrelin on inflammatory response in lung contusion

(2012) Berrak Guven et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Ghrelin Protects Spinal Cord Motoneurons Against Chronic Glutamate Excitotoxicity by Inhibiting Microglial Activation

(2012) Sungyoub Lee et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Ghrelin induces cell migration through GHSR1a-mediated PI3K/Akt/eNOS/NO signaling pathway in endothelial progenitor cells

(2012) Xiaodong Chen et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Targeted estrogen delivery reverses the metabolic syndrome

(2012) Brian Finan et al.   NATURE MEDICINE

Ghrelin signaling in heart remodeling of adult obese mice

(2012) Glauciane Lacerda-Miranda et al.   PEPTIDES

Ghrelin Treatment of Cachectic Patients with Chronic Obstructive Pulmonary Disease: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

(2012) Keisuke Miki et al.   PLoS One

Hypothalamic mTOR Signaling Mediates the Orexigenic Action of Ghrelin

(2012) Luís Martins et al.   PLoS One

The Amygdala as a Neurobiological Target for Ghrelin in Rats: Neuroanatomical, Electrophysiological and Behavioral Evidence

(2012) Mayte Alvarez-Crespo et al.   PLoS One

Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptor

(2012) S. Mary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility

(2012) Q. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ghrelin improves body weight loss and skeletal muscle catabolism associated with angiotensin II-induced cachexia in mice

(2012) Masako Sugiyama et al.   REGULATORY PEPTIDES

Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues

(2011) Ligen Lin et al.   AGING CELL

Randomised clinical trial: ghrelin agonist TZP-101 relieves gastroparesis associated with severe nausea and vomiting - randomised clinical study subset data

(2011) J. M. Wo et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Genetic Association between Ghrelin Polymorphisms and Alzheimer’s Disease in a Japanese Population

(2011) Nobuto Shibata et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

The Central Sirtuin 1/p53 Pathway Is Essential for the Orexigenic Action of Ghrelin

(2011) D. A. Velasquez et al.   DIABETES

Local infusion of ghrelin enhanced hippocampal synaptic plasticity and spatial memory through activation of phosphoinositide 3-kinase in the dentate gyrus of adult rats

(2011) Liang Chen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Ghrelin ameliorates bleomycin-induced acute lung injury by protecting alveolar epithelial cells and suppressing lung inflammation

(2011) Yoshifumi Imazu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ghrelin protects spinal cord motoneurons against chronic glutamate-induced excitotoxicity via ERK1/2 and phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3β pathways

(2011) Eunjin Lim et al.   EXPERIMENTAL NEUROLOGY

Rikkunshito Improves the Symptoms in Patients with Functional Dyspepsia, Accompanied by an Increase in the Level of Plasma Ghrelin

(2011) Makoto Arai et al.   HEPATO-GASTROENTEROLOGY

Ghrelin ameliorates hypoxia-induced pulmonary hypertension via phospho-GSK3β/β-catenin signaling in neonatal rats

(2011) Yan-ping Xu et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

(2011) Thomas Philips et al.   LANCET NEUROLOGY

The Peptidic GHS-R antagonist [D-Lys3]GHRP-6 markedly improves adiposity and related metabolic abnormalities in a mouse model of postmenopausal obesity

(2011) L. Maletínská et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Polymorphisms in genes encoding leptin, ghrelin and their receptors in German multiple sclerosis patients

(2011) Linda K. Rey et al.   MOLECULAR AND CELLULAR PROBES

Ghrelin directly targets the ventral tegmental area to increase food motivation

(2011) K.P. Skibicka et al.   NEUROSCIENCE

Role of ghrelin system in neuroprotection and cognitive functions: Implications in Alzheimer's disease

(2011) Manuel D. Gahete et al.   PEPTIDES

Exogenous ghrelin improves blood flow distribution in pulmonary hypertension—assessed using synchrotron radiation microangiography

(2011) Daryl O. Schwenke et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

High-Fat Diet with Acyl-Ghrelin Treatment Leads to Weight Gain with Low Inflammation, High Oxidative Capacity and Normal Triglycerides in Rat Muscle

(2011) Rocco Barazzoni et al.   PLoS One

Ghrelin Modulates Insulin Sensitivity and Tau Phosphorylation in High Glucose-Induced Hippocampal Neurons

(2010) Ying Chen et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Relation of ghrelin, leptin and inflammatory markers to nutritional status in active pulmonary tuberculosis

(2010) Ji Hae Kim et al.   CLINICAL NUTRITION

Inhibition of Apoptotic Cell Death by Ghrelin Improves Functional Recovery after Spinal Cord Injury

(2010) Jee Y. Lee et al.   ENDOCRINOLOGY

Diet-Induced Obesity Causes Ghrelin Resistance in Arcuate NPY/AgRP Neurons

(2010) Dana I. Briggs et al.   ENDOCRINOLOGY

Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender

(2010) Ricardo Lage et al.   FASEB JOURNAL

Postprandial ghrelin response is reduced in patients with Parkinson’s disease and idiopathic REM sleep behaviour disorder: a peripheral biomarker for early Parkinson’s disease?

(2010) Marcus M. Unger et al.   JOURNAL OF NEUROLOGY

Agrp Neurons Mediate Sirt1's Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity

(2010) M. O. Dietrich et al.   JOURNAL OF NEUROSCIENCE

The Anti-Inflammatory and Neuroprotective Effects of Ghrelin in Subarachnoid Hemorrhage-Induced Oxidative Brain Damage in Rats

(2010) Mehmet Erşahin et al.   JOURNAL OF NEUROTRAUMA

Altered myocardial expression of ghrelin and its receptor (GHSR-1a) in patients with severe heart failure

(2010) Andres Beiras-Fernandez et al.   PEPTIDES

Ghrelin induced memory facilitation implicates nitric oxide synthase activation and decrease in the threshold to promote LTP in hippocampal dentate gyrus

(2010) Valeria P. Carlini et al.   PHYSIOLOGY & BEHAVIOR

Ghrelin Is Produced in Taste Cells and Ghrelin Receptor Null Mice Show Reduced Taste Responsivity to Salty (NaCl) and Sour (Citric Acid) Tastants

(2010) Yu-Kyong Shin et al.   PLoS One

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice

(2010) T.-J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum ghrelin is inversely associated with cognitive function in a sample of non-demented elderly

(2010) Mary Beth Spitznagel et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor

(2010) B. P. Barnett et al.   SCIENCE

Ghrelin Suppresses Inflammation and Neuronal Nitric Oxide Synthase in Focal Cerebral Ischemia Via the Vagus Nerve

(2010) Cletus Cheyuo et al.   SHOCK

Growth Hormone Releasing Peptide-2, a Ghrelin Agonist, Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Rats

(2010) Guang Li et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Ghrelin and its potential in the treatment of eating/wasting disorders and cachexia

(2010) Timo D. Müller et al.   Journal of Cachexia Sarcopenia and Muscle

Ghrelin inhibits skeletal muscle protein breakdown in rats with thermal injury through normalizing elevated expression of E3 ubiquitin ligases MuRF1 and MAFbx

(2009) Ambikaipakan Balasubramaniam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Ghrelin Attenuates Acute Pancreatitis-Induced Lung Injury and Inhibits Substance P Expression

(2009) Xiaolei Zhou et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Ghrelin reverses experimental diabetic neuropathy in mice

(2009) Itaru Kyoraku et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Comparison of Gastric Emptying and Plasma Ghrelin Levels in Patients with Functional Dyspepsia and Non-Erosive Reflux Disease

(2009) Tomotaka Shindo et al.   DIGESTION

Plasma Ghrelin Levels and Their Relationship with Gastric Emptying in Patients with Dysmotility-Like Functional Dyspepsia

(2009) K.J. Lee et al.   DIGESTION

Ghrelin Increases Hunger and Food Intake in Patients with Restricting-type Anorexia Nervosa: A Pilot Study

(2009) Mari HOTTA et al.   ENDOCRINE JOURNAL

Suppression of Experimental Autoimmune Encephalomyelitis by Ghrelin

(2009) M.-M. Theil et al.   JOURNAL OF IMMUNOLOGY

Ghrelin Promotes and Protects Nigrostriatal Dopamine Function via a UCP2-Dependent Mitochondrial Mechanism

(2009) Z. B. Andrews et al.   JOURNAL OF NEUROSCIENCE

Desacyl-ghrelin and synthetic GH-secretagogues modulate the production of inflammatory cytokines in mouse microglia cells stimulated by β-amyloid fibrils

(2009) Ilaria Bulgarelli et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Sustained appetite improvement in malnourished dialysis patients by daily ghrelin treatment

(2009) Damien R. Ashby et al.   KIDNEY INTERNATIONAL

Metabolic regulation of ghrelin O-acyl transferase (GOAT) expression in the mouse hypothalamus, pituitary, and stomach

(2009) Manuel D. Gahete et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

An Acyl-Ghrelin-Specific Neutralizing Antibody Inhibits the Acute Ghrelin-Mediated Orexigenic Effects in Mice

(2009) S.-C. Lu et al.   MOLECULAR PHARMACOLOGY

Growth Hormone Secretagogues and Growth Hormone Releasing Peptides Act As Orthosteric Super-Agonists but Not Allosteric Regulators for Activation of the G Protein G o1 by the Ghrelin Receptor

(2009) K. A. Bennett et al.   MOLECULAR PHARMACOLOGY

GOAT links dietary lipids with the endocrine control of energy balance

(2009) Henriette Kirchner et al.   NATURE MEDICINE

Neuroprotective Effect of Ghrelin in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson’s Disease by Blocking Microglial Activation

(2009) Minho Moon et al.   NEUROTOXICITY RESEARCH

Ghrelin inhibits post-infarct myocardial remodeling and improves cardiac function through anti-inflammation effect

(2009) Cong-Xin Huang et al.   PEPTIDES

Safety, tolerability and pharmacokinetics of intravenous ghrelin for cancer-related anorexia/cachexia: a randomised, placebo-controlled, double-blind, double-crossover study

(2008) F Strasser et al.   BRITISH JOURNAL OF CANCER

Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone

(2008) Jing Yang et al.   CELL

Hypothalamic Fatty Acid Metabolism Mediates the Orexigenic Action of Ghrelin

(2008) Miguel López et al.   Cell Metabolism

Effect of Des-acyl Ghrelin on Adiposity and Glucose Metabolism

(2008) Weizhen Zhang et al.   ENDOCRINOLOGY

Repeated administration of ghrelin to patients with functional dyspepsia: its effects on food intake and appetite.

(2008) Takashi Akamizu et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Long-acting octreotide treatment causes a sustained decrease in ghrelin concentrations but does not affect weight, behaviour and appetite in subjects with Prader–Willi syndrome

(2008) Kathleen De Waele et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra

(2008) Hong Jiang et al.   EXPERIMENTAL NEUROLOGY

Ghrelin-induced growth hormone release from goldfish pituitary cells involves voltage-sensitive calcium channels

(2008) Caleb L. Grey et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Novel Ghrelin Assays Provide Evidence for Independent Regulation of Ghrelin Acylation and Secretion in Healthy Young Men

(2008) Jianhua Liu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Plasma ghrelin and leptin in adult cystic fibrosis patients

(2008) Rubin I Cohen et al.   Journal of Cystic Fibrosis

UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

(2008) Zane B. Andrews et al.   NATURE

Desacyl ghrelin inhibits the orexigenic effect of peripherally injected ghrelin in rats

(2008) Tobias Inhoff et al.   PEPTIDES

Ghrelin octanoylation mediated by an orphan lipid transferase

(2008) J. A. Gutierrez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ghrelin treatment suppresses neutrophil-dominant inflammation in airways of patients with chronic respiratory infection

(2008) Tsuyoshi Kodama et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Growth hormone releasing peptide 2 reverses anorexia associated with chemotherapy with 5-fluoruracil in colon cancer cell-bearing mice

(2008) Simona Perboni et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Gastric motor effects of ghrelin and growth hormone releasing peptide 6 in diabetic mice with gastroparesis

(2008) Wen-Cai Qiu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Ghrelin improves delayed gastrointestinal transit in alloxan-induced diabetic mice

(2008) Wen-Cai Qiu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure

(2007) Paul T. Pfluger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Ghrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction

(2007) Takeshi Soeki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons

(2007) Daisuke Kohno et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of Adult Ghrelin and Ghrelin Receptor Knockout Mice under Positive and Negative Energy Balance

(2007) Yuxiang Sun et al.   ENDOCRINOLOGY

Exogenous Ghrelin Attenuates the Progression of Chronic Hypoxia-Induced Pulmonary Hypertension in Conscious Rats

(2007) Daryl O. Schwenke et al.   ENDOCRINOLOGY

Ghrelin Treatment of Chronic Kidney Disease: Improvements in Lean Body Mass and Cytokine Profile

(2007) Mark D. DeBoer et al.   ENDOCRINOLOGY