RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation

Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome

(2021) Isioma I.I. Enwerem et al.   RNA

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Tob2 phosphorylation regulates global mRNA turnover to reshape transcriptome and impact cell proliferation

(2020) Chyi-Ying A Chen et al.   RNA

mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence

(2020) Soo Seok Hwang et al.   SCIENCE

The Ccr4-Not complex monitors the translating ribosome for codon optimality

(2020) Robert Buschauer et al.   SCIENCE

RNF219 interacts with CCR4‒NOT in regulating stem cell differentiation

(2020) Hao Du et al.   Journal of Molecular Cell Biology

RNA-binding proteins distinguish between similar sequence motifs to promote targeted deadenylation by Ccr4-Not

(2019) Michael W Webster et al.   eLife

A conserved CAF40-binding motif in metazoan NOT4 mediates association with the CCR4–NOT complex

(2019) Csilla Keskeny et al.   GENES & DEVELOPMENT

DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity

(2019) Hedda A Meijer et al.   NUCLEIC ACIDS RESEARCH

The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing

(2019) Philippe Coulombe et al.   Nature Communications

Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation

(2019) Tobias Raisch et al.   Nature Communications

Ribosome pausing, a dangerous necessity for co-translational events

(2019) Martine A Collart et al.   NUCLEIC ACIDS RESEARCH

Unique repression domains of Pumilio utilize deadenylation and decapping factors to accelerate destruction of target mRNAs

(2019) René M Arvola et al.   NUCLEIC ACIDS RESEARCH

Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment

(2018) D. Bulbrook et al.   JOURNAL OF MOLECULAR BIOLOGY

Degradation of a Novel DNA Damage Response Protein, Tankyrase 1 Binding Protein 1, following Adenovirus Infection

(2018) Nafiseh Chalabi Hagkarim et al.   JOURNAL OF VIROLOGY

High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies

(2018) Ji-Young Youn et al.   MOLECULAR CELL

mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases

(2018) Michael W. Webster et al.   MOLECULAR CELL

PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay

(2018) Hyerim Yi et al.   MOLECULAR CELL

Analysis of mRNA deadenylation by multi-protein complexes

(2017) Michael W. Webster et al.   METHODS

Architecture of the human interactome defines protein communities and disease networks

(2017) Edward L. Huttlin et al.   NATURE

m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition

(2017) Boxuan Simen Zhao et al.   NATURE

Drosophila Bag-of-marbles directly interacts with the CAF40 subunit of the CCR4–NOT complex to elicit repression of mRNA targets

(2017) Annamaria Sgromo et al.   RNA

A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin

(2017) Annamaria Sgromo et al.   Nature Communications

Cytoplasmic RNA decay pathways - Enzymes and mechanisms

(2016) Anna Łabno et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Distinct modes of recruitment of the CCR4–NOT complex byDrosophilaand vertebrate Nanos

(2016) Tobias Raisch et al.   EMBO JOURNAL

Acetylation-Dependent Control of Global Poly(A) RNA Degradation by CBP/p300 and HDAC1/2

(2016) Sahil Sharma et al.   MOLECULAR CELL

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes

(2016) Florian Weissmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The architecture of the Schizosaccharomyces pombe CCR4-NOT complex

(2016) Marta Ukleja et al.   Nature Communications

BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation

(2016) Benjamin Stupfler et al.   Nature Communications

Reconstitution of Targeted Deadenylation by the Ccr4-Not Complex and the YTH Domain Protein Mmi1

(2016) James A.W. Stowell et al.   Cell Reports

The Ccr4-Not complex is a key regulator of eukaryotic gene expression

(2016) Martine A. Collart   Wiley Interdisciplinary Reviews-RNA

CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State

(2016) Xiaofeng Zheng et al.   Stem Cell Reports

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

(2015) Takashi Mino et al.   CELL

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

(2015) Erik Arner et al.   SCIENCE

A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C

(2015) Florencia Cano et al.   Nature Communications

A Scalable Genome-Editing-Based Approach for Mapping Multiprotein Complexes in Human Cells

(2015) Mathieu Dalvai et al.   Cell Reports

mRNA deadenylation by Pan2–Pan3: Figure 1

(2014) Jana Wolf et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression

(2014) D. Bhandari et al.   GENES & DEVELOPMENT

Control of Pro-Angiogenic Cytokine mRNA Half-Life in Cancer: The Role of AU-Rich Elements and Associated Proteins

(2014) Paola Griseri et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

A DDX6-CNOT1 Complex and W-Binding Pockets in CNOT9 Reveal Direct Links between miRNA Target Recognition and Silencing

(2014) Ying Chen et al.   MOLECULAR CELL

Structural and Biochemical Insights to the Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression

(2014) Hansruedi Mathys et al.   MOLECULAR CELL

Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1

(2014) Christopher Rouya et al.   RNA

Global target mRNA specification and regulation by the RNA-binding protein ZFP36

(2014) Neelanjan Mukherjee et al.   GENOME BIOLOGY

Novel roles of the multi-functional CCR4-NOT complex in post-transcriptional regulation

(2014) Toshifumi Inada et al.   Frontiers in Genetics

RNA decay machines: Deadenylation by the Ccr4–Not and Pan2–Pan3 complexes

(2013) Elmar Wahle et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Roquin Promotes Constitutive mRNA Decay via a Conserved Class of Stem-Loop Recognition Motifs

(2013) Kathrin Leppek et al.   CELL

Thein VivoTRPV6 Protein Starts at a Non-AUG Triplet, Decoded as Methionine, Upstream of Canonical Initiation at AUG

(2013) Claudia Fecher-Trost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression

(2013) Achim Werner et al.   NATURE CELL BIOLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Structure and assembly of the NOT module of the human CCR4–NOT complex

(2013) Andreas Boland et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and RNA-binding properties of the Not1–Not2–Not5 module of the yeast Ccr4–Not complex

(2013) Varun Bhaskar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for the recruitment of the human CCR4–NOT deadenylase complex by tristetraprolin

(2013) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex

(2013) Fabienne Mauxion et al.   RNA Biology

NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain

(2013) Praveen Bawankar et al.   RNA Biology

The CCR4-NOT Complex Mediates Deadenylation and Degradation of Stem Cell mRNAs and Promotes Planarian Stem Cell Differentiation

(2013) Jordi Solana et al.   PLoS Genetics

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Architecture of the Nuclease Module of the Yeast Ccr4-Not Complex: the Not1-Caf1-Ccr4 Interaction

(2012) Jérôme Basquin et al.   MOLECULAR CELL

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4–NOT deadenylase complex

(2012) Alain-Pierre Petit et al.   NUCLEIC ACIDS RESEARCH

Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms

(2011) P de Bie et al.   CELL DEATH AND DIFFERENTIATION

Insights into the structure of the CCR4-NOT complex by electron microscopy

(2011) Fariborz Nasertorabi et al.   FEBS LETTERS

The Ccr4–Not complex

(2011) Martine A. Collart et al.   GENE

Deciphering correct strategies for multiprotein complex assembly by co-expression: Application to complexes as large as the histone octamer

(2011) Marie-Laure Diebold et al.   JOURNAL OF STRUCTURAL BIOLOGY

Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin

(2011) Heike Sandler et al.   NUCLEIC ACIDS RESEARCH

Human Pat1b Connects Deadenylation with mRNA Decapping and Controls the Assembly of Processing Bodies

(2010) S. Ozgur et al.   MOLECULAR AND CELLULAR BIOLOGY

Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression

(2010) Elke Glasmacher et al.   NATURE IMMUNOLOGY

Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation

(2010) C. Temme et al.   RNA

Mechanisms of deadenylation-dependent decay

(2010) Chyi-Ying A. Chen et al.   Wiley Interdisciplinary Reviews-RNA

Networks controlling mRNA decay in the immune system

(2010) Johanna Schott et al.   Wiley Interdisciplinary Reviews-RNA

Human Ccr4–Not complexes contain variable deadenylase subunits

(2009) Nga-Chi Lau et al.   BIOCHEMICAL JOURNAL

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

The Multiple Layers of Ubiquitin-Dependent Cell Cycle Control

(2009) Katherine Wickliffe et al.   CHEMICAL REVIEWS

The mammalian anti-proliferative BTG/Tob protein family

(2009) G. Sebastiaan Winkler   JOURNAL OF CELLULAR PHYSIOLOGY

BTG/TOB factors impact deadenylases

(2009) Fabienne Mauxion et al.   TRENDS IN BIOCHEMICAL SCIENCES

The BTG2 protein is a general activator of mRNA deadenylation

(2008) Fabienne Mauxion et al.   EMBO JOURNAL

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY