Unique repression domains of Pumilio utilize deadenylation and decapping factors to accelerate destruction of target mRNAs

Inhibiting transcription in cultured metazoan cells with actinomycin D to monitor mRNA turnover

(2019) Wi S. Lai et al.   METHODS

RNA-binding proteins distinguish between similar sequence motifs to promote targeted deadenylation by Ccr4-Not

(2019) Michael W Webster et al.   eLife

Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation

(2019) Tobias Raisch et al.   Nature Communications

A Mild PUM1 Mutation Is Associated with Adult-Onset Ataxia, whereas Haploinsufficiency Causes Developmental Delay and Seizures

(2018) Vincenzo A. Gennarino et al.   CELL

Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes

(2018) Tobias Brandmann et al.   EMBO JOURNAL

mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases

(2018) Michael W. Webster et al.   MOLECULAR CELL

PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay

(2018) Hyerim Yi et al.   MOLECULAR CELL

Post-transcriptional Regulatory Functions of Mammalian Pumilio Proteins

(2018) Aaron C. Goldstrohm et al.   TRENDS IN GENETICS

Post-transcriptional regulation of mouse neurogenesis by Pumilio proteins

(2017) Meng Zhang et al.   GENES & DEVELOPMENT

brms: An R Package for Bayesian Multilevel Models Using Stan

(2017) Paul-Christian Bürkner   Journal of Statistical Software

Stan: A Probabilistic Programming Language

(2017) Bob Carpenter et al.   Journal of Statistical Software

Integrated analysis of RNA-binding protein complexes using in vitro selection and high-throughput sequencing and sequence specificity landscapes (SEQRS)

(2017) Tzu-Fang Lou et al.   METHODS

Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins

(2017) Jennifer A Bohn et al.   NUCLEIC ACIDS RESEARCH

Combinatorial control of messenger RNAs by Pumilio, Nanos and Brain Tumor Proteins

(2017) René M. Arvola et al.   RNA Biology

Drosophila Bag-of-marbles directly interacts with the CAF40 subunit of the CCR4–NOT complex to elicit repression of mRNA targets

(2017) Annamaria Sgromo et al.   RNA

Birth and Death of Histone mRNAs

(2017) William F. Marzluff et al.   TRENDS IN GENETICS

A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin

(2017) Annamaria Sgromo et al.   Nature Communications

An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline1

(2016) Winifred Mak et al.   BIOLOGY OF REPRODUCTION

Nanos-mediated repression ofhidprotects larval sensory neurons after a global switch in sensitivity to apoptotic signals

(2016) Balpreet Bhogal et al.   DEVELOPMENT

Distinct modes of recruitment of the CCR4–NOT complex byDrosophilaand vertebrate Nanos

(2016) Tobias Raisch et al.   EMBO JOURNAL

The DDX6–4E-T interaction mediates translational repression and P-body assembly

(2016) Anastasiia Kamenska et al.   NUCLEIC ACIDS RESEARCH

Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences

(2016) Volker Boehm et al.   Nature Communications

Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio

(2016) Chase A Weidmann et al.   eLife

Pumilio1 Haploinsufficiency Leads to SCA1-like Neurodegeneration by Increasing Wild-Type Ataxin1 Levels

(2015) Vincenzo A. Gennarino et al.   CELL

Coordinate post-transcriptional repression of Dpp-dependent transcription factors attenuates signal range during development

(2015) Fay G. Newton et al.   DEVELOPMENT

Reduced Pumilio-2 expression in patients with temporal lobe epilepsy and in the lithium–pilocarpine induced epilepsy rat model

(2015) Xu-Ling Wu et al.   EPILEPSY & BEHAVIOR

Towards a molecular understanding of microRNA-mediated gene silencing

(2015) Stefanie Jonas et al.   NATURE REVIEWS GENETICS

XenopusCAF1 requires NOT1-mediated interaction with 4E-T to repress translation in vivo

(2015) Shruti Waghray et al.   RNA

The Crystal Structure of the NHL Domain in Complex with RNA Reveals the Molecular Basis of Drosophila Brain-Tumor-Mediated Gene Regulation

(2015) Inga Loedige et al.   Cell Reports

Brain tumor is a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transition

(2015) John D Laver et al.   GENOME BIOLOGY

The NHL domain of BRAT is an RNA-binding domain that directly contacts the hunchback mRNA for regulation

(2014) I. Loedige et al.   GENES & DEVELOPMENT

Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression

(2014) D. Bhandari et al.   GENES & DEVELOPMENT

The RNA binding domain of Pumilio antagonizes poly-adenosine binding protein and accelerates deadenylation

(2014) Chase A. Weidmann et al.   RNA

Deadenylation of mRNA by the CCR4–NOT complex in Drosophila: molecular and developmental aspects

(2014) Claudia Temme et al.   Frontiers in Genetics

The role of disordered protein regions in the assembly of decapping complexes and RNP granules

(2013) S. Jonas et al.   GENES & DEVELOPMENT

Pumilio-2 Regulates Translation of Nav1.6 to Mediate Homeostasis of Membrane Excitability

(2013) H. E. Driscoll et al.   JOURNAL OF NEUROSCIENCE

miRISC recruits decapping factors to miRNA targets to enhance their degradation

(2013) T. Nishihara et al.   NUCLEIC ACIDS RESEARCH

The CCR4 Deadenylase Acts with Nanos and Pumilio in the Fine-Tuning of Mei-P26 Expression to Promote Germline Stem Cell Self-Renewal

(2013) Willy Joly et al.   Stem Cell Reports

Pumilio 1 Suppresses Multiple Activators of p53 to Safeguard Spermatogenesis

(2012) Dong Chen et al.   CURRENT BIOLOGY

Pumilio facilitates miRNA regulation of the E2F3 oncogene

(2012) W. O. Miles et al.   GENES & DEVELOPMENT

Human Pumilio Proteins Recruit Multiple Deadenylases to Efficiently Repress Messenger RNAs

(2012) Jamie Van Etten et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Eukaryotic Translation Initiation Factor 4E-Binding Protein Promotes mRNA Decapping and Is Required for PUF Repression

(2012) N. H. Blewett et al.   MOLECULAR AND CELLULAR BIOLOGY

Brat Promotes Stem Cell Differentiation via Control of a Bistable Switch that Restricts BMP Signaling

(2011) Robin E. Harris et al.   DEVELOPMENTAL CELL

Deciphering correct strategies for multiprotein complex assembly by co-expression: Application to complexes as large as the histone octamer

(2011) Marie-Laure Diebold et al.   JOURNAL OF STRUCTURAL BIOLOGY

Drosophila Pumilio Protein Contains Multiple Autonomous Repression Domains That Regulate mRNAs Independently of Nanos and Brain Tumor

(2011) C. A. Weidmann et al.   MOLECULAR AND CELLULAR BIOLOGY

Pumilio-2 Function in the Mouse Nervous System

(2011) Henrike Siemen et al.   PLoS One

Translational Repression by Deadenylases

(2010) Amy Cooke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HPat provides a link between deadenylation and decapping in metazoa

(2010) Gabrielle Haas et al.   JOURNAL OF CELL BIOLOGY

Human Pat1b Connects Deadenylation with mRNA Decapping and Controls the Assembly of Processing Bodies

(2010) S. Ozgur et al.   MOLECULAR AND CELLULAR BIOLOGY

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mammalian Pumilio 2 regulates dendrite morphogenesis and synaptic function

(2010) J. P. Vessey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation

(2010) C. Temme et al.   RNA

Genome-wide analysis of mRNA decay patterns during early Drosophila development

(2010) Stefan Thomsen et al.   GENOME BIOLOGY

Human Ccr4–Not complexes contain variable deadenylase subunits

(2009) Nga-Chi Lau et al.   BIOCHEMICAL JOURNAL

The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments

(2009) S. A. Bustin et al.   CLINICAL CHEMISTRY

FBF and Its Dual Control of gld-1 Expression in the Caenorhabditis elegans Germline

(2009) N. Suh et al.   GENETICS

The Translational Repressors Nanos and Pumilio Have Divergent Effects on Presynaptic Terminal Growth and Postsynaptic Glutamate Receptor Subunit Composition

(2009) K. P. Menon et al.   JOURNAL OF NEUROSCIENCE

Structural Basis for the Mutually Exclusive Anchoring of P Body Components EDC3 and Tral to the DEAD Box Protein DDX6/Me31B

(2009) Felix Tritschler et al.   MOLECULAR CELL

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Pumilio 2 controls translation by competing with eIF4E for 7-methyl guanosine cap recognition

(2009) Q. Cao et al.   RNA

Pumilio Binds para mRNA and Requires Nanos and Brat to Regulate Sodium Current in Drosophila Motoneurons

(2008) N. I. Muraro et al.   JOURNAL OF NEUROSCIENCE

Multifunctional deadenylase complexes diversify mRNA control

(2008) Aaron C. Goldstrohm et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY