Silencing and Transcriptional Regulation of Endogenous Retroviruses: An Overview

SPEN integrates transcriptional and epigenetic control of X-inactivation

(2020) François Dossin et al.   NATURE

Structure of Drosophila melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag

(2020) Matthew A. Cottee et al.   Science Advances

Specific subfamilies of transposable elements contribute to different domains of T lymphocyte enhancers

(2020) Mengliang Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SETDB1-Mediated Silencing of Retroelements

(2020) Kei Fukuda et al.   Viruses-Basel

KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage

(2020) Gernot Wolf et al.   eLife

Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation

(2020) Ava C Carter et al.   eLife

Chronic HCV Infection Is Associated with Overexpression of Human Endogenous Retroviruses that Persists after Drug-Induced Viral Clearance

(2020) Pier-Angelo Tovo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Frequent retroviral gene co-option during the evolution of vertebrates

(2020) Jianhua Wang et al.   MOLECULAR BIOLOGY AND EVOLUTION

Dnmt1 binds and represses genomic retroelements via DNA methylation in mouse early embryos

(2020) Byungkuk Min et al.   NUCLEIC ACIDS RESEARCH

Methylation-directed glycosylation of chromatin factors represses retrotransposon promoters

(2020) Mathieu Boulard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transactivation of human endogenous retroviruses by tumor viruses and their functions in virus-associated malignancies

(2019) Jungang Chen et al.   Oncogenesis

SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells

(2019) Parysatis Sachs et al.   Nature Communications

The Lupus Susceptibility Locus Sgp3 Encodes the Suppressor of Endogenous Retrovirus Expression SNERV

(2019) Rebecca S. Treger et al.   IMMUNITY

The KRAB-Zinc finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons

(2019) Michelle K. Y. Seah et al.   DEVELOPMENT

Origins and evolutionary consequences of ancient endogenous retroviruses

(2019) Welkin E. Johnson   NATURE REVIEWS MICROBIOLOGY

pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis

(2019) David Kremer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Arms Race Between KRAB–Zinc Finger Proteins and Endogenous Retroelements and Its Impact on Mammals

(2019) Melania Bruno et al.   Annual Review of Genetics

Close to the Bedside: A Systematic Review of Endogenous Retroviruses and Their Impact in Oncology

(2019) David F. Grabski et al.   JOURNAL OF SURGICAL RESEARCH

Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells

(2019) Yanxiao Zhang et al.   NATURE GENETICS

Transposable elements in human genetic disease

(2019) Lindsay M. Payer et al.   NATURE REVIEWS GENETICS

On the origin of a pathogenic HERV-W envelope protein present in multiple sclerosis lesions

(2019) Klemens Ruprecht et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Children With Autism Spectrum Disorder and Their Mothers Share Abnormal Expression of Selected Endogenous Retroviruses Families and Cytokines

(2019) Emanuela Balestrieri et al.   Frontiers in Immunology

Unintegrated HIV-1 DNAs are loaded with core and linker histones and transcriptionally silenced

(2019) Franziska K. Geis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous retroviruses are associated with hippocampus-based memory impairment

(2019) Roman Sankowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Embryonic Cells Redistribute SUMO1 upon Forced SUMO1 Overexpression

(2019) Andreia Lee et al.   mBio

TRIM28 and the control of transposable elements in the brain

(2018) Daniela A. Grassi et al.   BRAIN RESEARCH

The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer

(2018) Elissa D. Pastuzyn et al.   CELL

Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons

(2018) James Ashley et al.   CELL

The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes

(2018) Luisa Robbez-Masson et al.   GENOME RESEARCH

Switching roles for DNA and histone methylation depend on evolutionary ages of human endogenous retroviruses

(2018) Hitoshi Ohtani et al.   GENOME RESEARCH

Ortervirales : New Virus Order Unifying Five Families of Reverse-Transcribing Viruses

(2018) Mart Krupovic et al.   JOURNAL OF VIROLOGY

Structural Basis of Heterochromatin Formation by Human HP1

(2018) Shinichi Machida et al.   MOLECULAR CELL

OUP accepted manuscript

(2018)   NUCLEIC ACIDS RESEARCH

A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing

(2018) Masaki Kato et al.   Nature Communications

HERV Envelope Proteins: Physiological Role and Pathogenic Potential in Cancer and Autoimmunity

(2018) Nicole Grandi et al.   Frontiers in Microbiology

KAP1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control

(2018) Christopher HC Tie et al.   EMBO REPORTS

Nomenclature for endogenous retrovirus (ERV) loci

(2018) Robert J. Gifford et al.   Retrovirology

The Implication of Early Chromatin Changes in X Chromosome Inactivation

(2018) Jan Jakub Żylicz et al.   CELL

NP220 mediates silencing of unintegrated retroviral DNA

(2018) Yiping Zhu et al.   NATURE

Aging-associated patterns in the expression of human endogenous retroviruses

(2018) Tapio Nevalainen et al.   PLoS One

The CUE1 domain of the SNF2-like chromatin remodeler SMARCAD1 mediates its association with KRAB-associated protein 1 (KAP1) and KAP1 target genes

(2017) Dong Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators

(2017) Nian Liu et al.   NATURE

Elsässer et al. reply

(2017) Simon J. Elsässer et al.   NATURE

On the role of H3.3 in retroviral silencing

(2017) Gernot Wolf et al.   NATURE

KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks

(2017) Michaël Imbeault et al.   NATURE

Hyperactivation of HUSH complex function by Charcot–Marie–Tooth disease mutation in MORC2

(2017) Iva A Tchasovnikarova et al.   NATURE GENETICS

Integration site selection by retroviruses and transposable elements in eukaryotes

(2017) Tania Sultana et al.   NATURE REVIEWS GENETICS

Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes

(2017) Cedric R. Clapier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568

(2017) Peng Yang et al.   SCIENCE

The Role of KRAB-ZFPs in Transposable Element Repression and Mammalian Evolution

(2017) Peng Yang et al.   TRENDS IN GENETICS

TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells

(2017) Per Ludvik Brattås et al.   Cell Reports

A human endogenous retrovirus-derived gene that can contribute to oncogenesis by activating the ERK pathway and inducing migration and invasion

(2017) Cécile Lemaître et al.   PLoS Pathogens

Endogenous Retroviruses: With Us and against Us

(2017) Thomas J. Meyer et al.   Frontiers in Chemistry

Histones Are Rapidly Loaded onto Unintegrated Retroviral DNAs Soon after Nuclear Entry

(2016) Gary Z. Wang et al.   Cell Host & Microbe

Activation of Endogenous Retroviruses in Dnmt1 −/− ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA

(2016) Jafar Sharif et al.   Cell Stem Cell

Molecular Criteria for Defining the Naive Human Pluripotent State

(2016) Thorold W. Theunissen et al.   Cell Stem Cell

Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues

(2016) Gabriela Ecco et al.   DEVELOPMENTAL CELL

Multiparameter functional diversity of human C2H2 zinc finger proteins

(2016) Frank W. Schmitges et al.   GENOME RESEARCH

NF-κB and IRF1 Induce Endogenous Retrovirus K Expression via Interferon-Stimulated Response Elements in Its 5′ Long Terminal Repeat

(2016) Mamneet Manghera et al.   JOURNAL OF VIROLOGY

Regulatory evolution of innate immunity through co-option of endogenous retroviruses

(2016) E. B. Chuong et al.   SCIENCE

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex

(2016) Richard T. Timms et al.   Cell Reports

Human endogenous retrovirus W in brain lesions: Rationale for targeted therapy in multiple sclerosis

(2016) Jack van Horssen et al.   Multiple Sclerosis and Related Disorders

Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells

(2015) Bin Xia Yang et al.   CELL

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

(2015) David Roulois et al.   CELL

Systematic Discovery of Xist RNA Binding Proteins

(2015) Ci Chu et al.   CELL

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

(2015) Katherine B. Chiappinelli et al.   CELL

Atrx promotes heterochromatin formation at retrotransposons

(2015) D. Sadic et al.   EMBO REPORTS

The KRAB zinc finger protein ZFP809 is required to initiate epigenetic silencing of endogenous retroviruses

(2015) Gernot Wolf et al.   GENES & DEVELOPMENT

Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells

(2015) Edward J. Grow et al.   NATURE

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3

(2015) Colleen A. McHugh et al.   NATURE

Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells

(2015) Simon J. Elsässer et al.   NATURE

C2H2 zinc finger proteins greatly expand the human regulatory lexicon

(2015) Hamed S Najafabadi et al.   NATURE BIOTECHNOLOGY

Retrotransposons shape species-specific embryonic stem cell gene expression

(2015) Luisa Robbez-Masson et al.   Retrovirology

A HUSH for transgene expression

(2015) T. R. Brummelkamp et al.   SCIENCE

Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells

(2015) I. A. Tchasovnikarova et al.   SCIENCE

A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation

(2015) A. Minajigi et al.   SCIENCE

Human endogenous retrovirus-K contributes to motor neuron disease

(2015) Wenxue Li et al.   Science Translational Medicine

TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells

(2015) Liana Fasching et al.   Cell Reports

Essential Role for Endogenous siRNAs during Meiosis in Mouse Oocytes

(2015) Paula Stein et al.   PLoS Genetics

Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the Krüppel-associated box zinc finger protein family

(2015) Gernot Wolf et al.   Mobile DNA

Endogenous Retroviruses in the Genomics Era

(2015) Welkin E. Johnson   Annual Review of Virology

Understanding the relationship between DNA methylation and histone lysine methylation

(2014) Nathan R. Rose et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Retroviral Transcriptional Regulation and Embryonic Stem Cells: War and Peace

(2014) Sharon Schlesinger et al.   MOLECULAR AND CELLULAR BIOLOGY

Suv39h-Dependent H3K9me3 Marks Intact Retrotransposons and Silences LINE Elements in Mouse Embryonic Stem Cells

(2014) Aydan Bulut-Karslioglu et al.   MOLECULAR CELL

Deep transcriptome profiling of mammalian stem cells supports a regulatory role for retrotransposons in pluripotency maintenance

(2014) Alexandre Fort et al.   NATURE GENETICS

The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity

(2014) Xinyi Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An antisense promoter in mouse L1 retrotransposon open reading frame-1 initiates expression of diverse fusion transcripts and limits retrotransposition

(2014) Jingfeng Li et al.   NUCLEIC ACIDS RESEARCH

De novo DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET

(2013) H. M. Rowe et al.   DEVELOPMENT

Endogenous retrovirus-K promoter: a landing strip for inflammatory transcription factors?

(2013) Mamneet Manghera et al.   Retrovirology

Human endogenous retrovirus K (HML-2) RNA and protein expression is a marker for human embryonic and induced pluripotent stem cells

(2013) Nina V Fuchs et al.   Retrovirology

Transposable elements as genetic regulatory substrates in early development

(2013) Wesley D. Gifford et al.   TRENDS IN CELL BIOLOGY

Distinct roles of KAP1, HP1 and G9a/GLP in silencing of the two-cell-specific retrotransposon MERVL in mouse ES cells

(2013) Irina A Maksakova et al.   Epigenetics & Chromatin

Proviral Silencing in Embryonic Cells Is Regulated by Yin Yang 1

(2013) Sharon Schlesinger et al.   Cell Reports

Transposable Elements: An Abundant and Natural Source of Regulatory Sequences for Host Genes

(2012) Rita Rebollo et al.   Annual Review of Genetics

Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development

(2012) S.-L. Tan et al.   DEVELOPMENT

Expression of Human Endogenous Retrovirus Type K (HML-2) Is Activated by the Tat Protein of HIV-1

(2012) M. J. Gonzalez-Hernandez et al.   JOURNAL OF VIROLOGY

HERVs Expression in Autism Spectrum Disorders

(2012) Emanuela Balestrieri et al.   PLoS One

HERV-H RNA is abundant in human embryonic stem cells and a precise marker for pluripotency

(2012) Federico A Santoni et al.   Retrovirology

DNA Methylation and SETDB1/H3K9me3 Regulate Predominantly Distinct Sets of Genes, Retroelements, and Chimeric Transcripts in mESCs

(2011) Mohammad M. Karimi et al.   Cell Stem Cell

Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A

(2011) Todd S. Macfarlan et al.   GENES & DEVELOPMENT

Gypsy and the Birth of the SCAN Domain

(2011) R. O. Emerson et al.   JOURNAL OF VIROLOGY

Regulation of X-chromosome inactivation by the X-inactivation centre

(2011) Sandrine Augui et al.   NATURE REVIEWS GENETICS

Lysine methyltransferase G9a is required for de novo DNA methylation and the establishment, but not the maintenance, of proviral silencing

(2011) D. C. Leung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebellum-specific and age-dependent expression of an endogenous retrovirus with intact coding potential

(2011) Kang-Hoon Lee et al.   Retrovirology

Dynamic control of endogenous retroviruses during development

(2011) Helen M. Rowe et al.   VIROLOGY

Retrotransposon-Induced Heterochromatin Spreading in the Mouse Revealed by Insertional Polymorphisms

(2011) Rita Rebollo et al.   PLoS Genetics

Repetitive Elements May Comprise Over Two-Thirds of the Human Genome

(2011) A. P. Jason de Koning et al.   PLoS Genetics

Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis

(2010) Renée Douville et al.   ANNALS OF NEUROLOGY

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues

(2010) Jacob H. Hanna et al.   CELL

KAP1 controls endogenous retroviruses in embryonic stem cells

(2010) Helen M. Rowe et al.   NATURE

L1 retrotransposition in neurons is modulated by MeCP2

(2010) Alysson R. Muotri et al.   NATURE

Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET

(2010) Toshiyuki Matsui et al.   NATURE

Long-range function of an intergenic retrotransposon

(2010) W. Pi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KRAB–Zinc Finger Proteins and KAP1 Can Mediate Long-Range Transcriptional Repression through Heterochromatin Spreading

(2010) Anna C. Groner et al.   PLoS Genetics

Histones, histone chaperones and nucleosome assembly

(2010) Rebecca J. Burgess et al.   Protein & Cell

Estimating enrichment of repetitive elements from high-throughput sequence data

(2010) Daniel S Day et al.   GENOME BIOLOGY

Embryonic stem cells use ZFP809 to silence retroviral DNAs

(2009) Daniel Wolf et al.   NATURE

Effects of Retroviruses on Host Genome Function

(2008) Patric Jern et al.   Annual Review of Genetics

Endogenous retroviruses

(2008) I. A. Maksakova et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endogenous retroviruses

(2008) C. Stocking et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A piRNA Pathway Primed by Individual Transposons Is Linked to De Novo DNA Methylation in Mice

(2008) Alexei A. Aravin et al.   MOLECULAR CELL

Structural insights into human KAP1 PHD finger–bromodomain and its role in gene silencing

(2008) Lei Zeng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

(2007) R. E. Randall et al.   JOURNAL OF GENERAL VIROLOGY