The Tumor Necrosis Factor Alpha and Interleukin 6 Auto-paracrine Signaling Loop Controls Mycobacterium avium Infection via Induction of IRF1/IRG1 in Human Primary Macrophages

Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses

(2021) Hui Feng et al.   PLoS Pathogens

Itaconate confers tolerance to late NLRP3 inflammasome activation

(2021) Monika Bambouskova et al.   Cell Reports

IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility

(2021) Ran Song et al.   Cell Reports

Effect of pH on the antimicrobial activity of the macrophage metabolite itaconate

(2021) Dustin Duncan et al.   MICROBIOLOGY-SGM

Absolute Quantification of the Central Carbon Metabolome in Eight Commonly Applied Prokaryotic and Eukaryotic Model Systems

(2020) Lisa M. Røst et al.   Metabolites

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

(2020) Alexander Hooftman et al.   Cell Metabolism

The Salmonella LysR family regulator, RipR, activates the SPI-13 encoded itaconate degradation cluster.

(2020) Steven J. Hersch et al.   INFECTION AND IMMUNITY

Frontline Science: Antibiotic treatment routes Mycobacterium avium to phagolysosomes without triggering proinflammatory cytokine production in human Mϕs

(2020) Signe Elisabeth Åsberg et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA viruses

(2019) Daisuke Yamane et al.   Nature Microbiology

An essential bifunctional enzyme in Mycobacterium tuberculosis for itaconate dissimilation and leucine catabolism

(2019) Hua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon regulatory factor 1 eliminates mycobacteria by suppressing p70 S6 kinase via mechanistic target of rapamycin signaling

(2019) Xinying Zhou et al.   JOURNAL OF INFECTION

Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair

(2019) Markus Ruetz et al.   SCIENCE

Improved phosphometabolome profiling applying isotope dilution strategy and capillary ion chromatography-tandem mass spectrometry

(2018) Marit H. Stafsnes et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Irg1expression in myeloid cells prevents immunopathology duringM. tuberculosisinfection

(2018) Sharmila Nair et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation

(2018) Cong-Hui Yao et al.   PLOS BIOLOGY

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

(2018) Monika Bambouskova et al.   NATURE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity

(2018) Jorge Domínguez-Andrés et al.   Cell Metabolism

Dimethyl Itaconate Is Not Metabolized into Itaconate Intracellularly

(2017) Mahmoud ElAzzouny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Persistent mycobacteria evade an antibacterial program mediated by phagolysosomal TLR7/8/MyD88 in human primary macrophages

(2017) Alexandre Gidon et al.   PLoS Pathogens

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Molecular basis of mycobacterial survival in macrophages

(2016) Jane Atesoh Awuh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation

(2016) David Langlais et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages

(2016) Aravind Tallam et al.   PLoS One

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid

(2016) Jan Naujoks et al.   PLoS Pathogens

Nontuberculous Mycobacteria Infections in Immunosuppressed Hosts

(2015) Emily Henkle et al.   CLINICS IN CHEST MEDICINE

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

(2015) Si Ming Man et al.   NATURE IMMUNOLOGY

Keap1 regulates inflammatory signaling inMycobacterium avium-infected human macrophages

(2015) Jane Atesoh Awuh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessment of capillary anion exchange ion chromatography tandem mass spectrometry for the quantitative profiling of the phosphometabolome and organic acids in biological extracts

(2014) Hans F.N. Kvitvang et al.   JOURNAL OF CHROMATOGRAPHY A

Bacterial itaconate degradation promotes pathogenicity

(2014) Jahminy Sasikaran et al.   Nature Chemical Biology

K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5

(2014) Kuzhuvelil B Harikumar et al.   NATURE IMMUNOLOGY

Cell-Autonomous Effector Mechanisms against Mycobacterium tuberculosis

(2014) J. D. MacMicking   Cold Spring Harbor Perspectives in Medicine

Immunoresponsive Gene 1 Augments Bactericidal Activity of Macrophage-Lineage Cells by Regulating β-Oxidation-Dependent Mitochondrial ROS Production

(2013) Christopher J. Hall et al.   Cell Metabolism

Endothelial TNF Receptor 2 Induces IRF1 Transcription Factor-Dependent Interferon-β Autocrine Signaling to Promote Monocyte Recruitment

(2013) Deepak Venkatesh et al.   IMMUNITY

Synergistic Activation of Inflammatory Cytokine Genes by Interferon-γ-Induced Chromatin Remodeling and Toll-like Receptor Signaling

(2013) Yu Qiao et al.   IMMUNITY

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis

(2012) Jan Sodenkamp et al.   IMMUNOBIOLOGY

Role of innate cytokines in mycobacterial infection

(2011) A M Cooper et al.   Mucosal Immunology

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Differential mechanisms of intracellular killing of Mycobacterium avium and Listeria monocytogenes by activated human and murine macrophages. The role of nitric oxide

(2010) L. E. BERMUDEZ   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

IntracellularMycobacterium aviumIntersect Transferrin in the Rab11+Recycling Endocytic Pathway and Avoid Lipocalin 2 Trafficking to the Lysosomal Pathway

(2010) Øyvind Halaas et al.   JOURNAL OF INFECTIOUS DISEASES

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells

(2009) Giuseppe Mancuso et al.   NATURE IMMUNOLOGY

Mycobacteria-induced granuloma necrosis depends on IRF-1

(2008) Sahar Aly et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon–response genes

(2008) Anna Yarilina et al.   NATURE IMMUNOLOGY