An essential bifunctional enzyme in Mycobacterium tuberculosis for itaconate dissimilation and leucine catabolism

Irg1expression in myeloid cells prevents immunopathology duringM. tuberculosisinfection

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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

CitE Enzymes Are Essential for Mycobacterium tuberculosis to Establish Infection in Macrophages and Guinea Pigs

(2018) Garima Arora et al.   Frontiers in Cellular and Infection Microbiology

Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation inMycobacterium tuberculosis

(2017) Susan Puckett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MolProbity: More and better reference data for improved all-atom structure validation

(2017) Christopher J. Williams et al.   PROTEIN SCIENCE

Metabolic anticipation in Mycobacterium tuberculosis

(2017) Hyungjin Eoh et al.   Nature Microbiology

Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense

(2016) Harding H. Luan et al.   Cell Metabolism

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

The Global Burden of Latent Tuberculosis Infection: A Re-estimation Using Mathematical Modelling

(2016) Rein M. G. J. Houben et al.   PLOS MEDICINE

Mycobacteria, metals, and the macrophage

(2015) Olivier Neyrolles et al.   IMMUNOLOGICAL REVIEWS

The Pfam protein families database: towards a more sustainable future

(2015) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

Bacterial l-leucine catabolism as a source of secondary metabolites

(2015) Alma L. Díaz-Pérez et al.   REVIEWS IN ENVIRONMENTAL SCIENCE AND BIO-TECHNOLOGY

Bacterial l-leucine catabolism as a source of secondary metabolites

(2015) Alma L. Díaz-Pérez et al.   REVIEWS IN ENVIRONMENTAL SCIENCE AND BIO-TECHNOLOGY

Bacterial itaconate degradation promotes pathogenicity

(2014) Jahminy Sasikaran et al.   Nature Chemical Biology

Nitrogen metabolism in Mycobacterium tuberculosis physiology and virulence

(2014) Alexandre Gouzy et al.   NATURE REVIEWS MICROBIOLOGY

Cysteine Is the General Base That Serves in Catalysis by Isocitrate Lyase and in Mechanism-Based Inhibition by 3-Nitropropionate

(2013) Margaret M. Moynihan et al.   BIOCHEMISTRY

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The crystal structures of the tri-functional Chloroflexus aurantiacus and bi-functional Rhodobacter sphaeroides malyl-CoA lyases and comparison with CitE-like superfamily enzymes and malate synthases

(2013) Jan Zarzycki et al.   BMC STRUCTURAL BIOLOGY

Structural insights into RipC, a putative citrate lyase β subunit from aYersinia pestisvirulence operon

(2011) Rodrigo Torres et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Kinetic and Chemical Mechanism of Malate Synthase fromMycobacterium tuberculosis

(2011) Christine E. Quartararo et al.   BIOCHEMISTRY

Itaconic Acid Is a Mammalian Metabolite Induced during Macrophage Activation

(2011) Cheryl L. Strelko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Methylaspartate Cycle in Haloarchaea

(2011) M. Khomyakova et al.   SCIENCE

The Apparent Malate Synthase Activity of Rhodobacter sphaeroides Is Due to Two Paralogous Enzymes, (3S)-Malyl-Coenzyme A (CoA)/ -Methylmalyl-CoA Lyase and (3S)- Malyl-CoA Thioesterase

(2010) T. J. Erb et al.   JOURNAL OF BACTERIOLOGY

Functional Insights into Human HMG-CoA Lyase from Structures of Acyl-CoA-containing Ternary Complexes

(2010) Zhuji Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The MycoBrowser portal: A comprehensive and manually annotated resource for mycobacterial genomes

(2010) Adamandia Kapopoulou et al.   TUBERCULOSIS

Myths and misconceptions: the origin and evolution of Mycobacterium tuberculosis

(2009) Noel H. Smith et al.   NATURE REVIEWS MICROBIOLOGY

Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2fixation cycle inChloroflexus aurantiacus

(2009) Jan Zarzycki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycobacterial persistence requires the utilization of host cholesterol

(2008) A. K. Pandey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Origin, Spread and Demography of the Mycobacterium tuberculosis Complex

(2008) Thierry Wirth et al.   PLoS Pathogens