Genetic Mechanisms Underlying the Evolution of Connectivity in the Human Cortex

Expression of human‐specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility

(2021) Lei Xing et al.   EMBO JOURNAL

Fossil apes and human evolution

(2021) Sergio Almécija et al.   SCIENCE

Sublamina-Specific Dynamics and Ultrastructural Heterogeneity of Layer 6 Excitatory Synaptic Boutons in the Adult Human Temporal Lobe Neocortex

(2021) Sandra Schmuhl-Giesen et al.   CEREBRAL CORTEX

Cross-platform validation of neurotransmitter release impairments in schizophrenia patient-derived NRXN1-mutant neurons

(2021) ChangHui Pak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Von Economo Neurons – Primate-Specific or Commonplace in the Mammalian Brain?

(2021) Ivan Banovac et al.   Frontiers in Neural Circuits

Wnt-Frizzled Signaling Regulates Activity-Mediated Synapse Formation

(2021) Samuel Teo et al.   Frontiers in Molecular Neuroscience

Hominini-specific regulation of CBLN2 increases prefrontal spinogenesis

(2021) Mikihito Shibata et al.   NATURE

Allometric rules for mammalian cortical layer 5 neuron biophysics

(2021) Lou Beaulieu-Laroche et al.   NATURE

A human-specific modifier of cortical connectivity and circuit function

(2021) Ewoud R. E. Schmidt et al.   NATURE

Dendritic action potentials and computation in human layer 2/3 cortical neurons

(2020) Albert Gidon et al.   SCIENCE

Transcriptomic evidence that von Economo neurons are regionally specialized extratelencephalic-projecting excitatory neurons

(2020) Rebecca D. Hodge et al.   Nature Communications

Whole-Neuron Synaptic Mapping Reveals Spatially Precise Excitatory/Inhibitory Balance Limiting Dendritic and Somatic Spiking

(2020) Daniel Maxim Iascone et al.   NEURON

Apical length governs computational diversity of layer 5 pyramidal neurons

(2020) Alessandro R Galloni et al.   eLife

Invariant Synapse Density and Neuronal Connectivity Scaling in Primate Neocortical Evolution

(2020) Chet C Sherwood et al.   CEREBRAL CORTEX

Conservation of brain connectivity and wiring across the mammalian class

(2020) Yaniv Assaf et al.   NATURE NEUROSCIENCE

Species-specific segmentation clock periods are due to differential biochemical reaction speeds

(2020) Mitsuhiro Matsuda et al.   SCIENCE

Species-specific pace of development is associated with differences in protein stability

(2020) Teresa Rayon et al.   SCIENCE

Direct estimation of mutations in great apes reconciles phylogenetic dating

(2019) Søren Besenbacher et al.   Nature Ecology & Evolution

Evolutionary expansion of connectivity between multimodal association areas in the human brain compared with chimpanzees

(2019) Dirk Jan Ardesch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Synaptic Perspective of Fragile X Syndrome and Autism Spectrum Disorders

(2019) Claudia Bagni et al.   NEURON

Neuron-Glia Signaling in Synapse Elimination

(2019) Daniel K. Wilton et al.   Annual Review of Neuroscience

Differential Structure of Hippocampal CA1 Pyramidal Neurons in the Human and Mouse

(2019) Ruth Benavides-Piccione et al.   CEREBRAL CORTEX

Not all cortical expansions are the same: the coevolution of the neocortex and the dorsal thalamus in mammals

(2019) Andrew C Halley et al.   CURRENT OPINION IN NEUROBIOLOGY

Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility

(2019) Hyejung Won et al.   Nature Communications

Conserved cell types with divergent features in human versus mouse cortex

(2019) Rebecca D. Hodge et al.   NATURE

Microglia Biology: One Century of Evolving Concepts

(2019) Marco Prinz et al.   CELL

Accelerated evolution of oligodendrocytes in the human brain

(2019) Stefano Berto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of vocal learning and spoken language

(2019) Erich D. Jarvis   SCIENCE

Ultrastructural heterogeneity of layer 4 excitatory synaptic boutons in the adult human temporal lobe neocortex

(2019) Rachida Yakoubi et al.   eLife

Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program

(2019) Laufey Geirsdottir et al.   CELL

Xenotransplanted Human Cortical Neurons Reveal Species-Specific Development and Functional Integration into Mouse Visual Circuits

(2019) Daniele Linaro et al.   NEURON

The human-specific paralogs SRGAP2B and SRGAP2C differentially modulate SRGAP2A-dependent synaptic development

(2019) Ewoud R. E. Schmidt et al.   Scientific Reports

The Dynamic Landscape of Open Chromatin during Human Cortical Neurogenesis

(2018) Luis de la Torre-Ubieta et al.   CELL

Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation

(2018) Ikuo K. Suzuki et al.   CELL

Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis

(2018) Ian T. Fiddes et al.   CELL

Quantitative Three-Dimensional Reconstructions of Excitatory Synaptic Boutons in Layer 5 of the Adult Human Temporal Lobe Neocortex: A Fine-Scale Electron Microscopic Analysis

(2018) Rachida Yakoubi et al.   CEREBRAL CORTEX

Human Cortical Pyramidal Neurons: From Spines to Spikes via Models

(2018) Guy Eyal et al.   Frontiers in Cellular Neuroscience

Parcellating Cerebral Cortex: How Invasive Animal Studies Inform Noninvasive Mapmaking in Humans

(2018) David C. Van Essen et al.   NEURON

Enhanced Dendritic Compartmentalization in Human Cortical Neurons

(2018) Lou Beaulieu-Laroche et al.   CELL

h-Channels Contribute to Divergent Intrinsic Membrane Properties of Supragranular Pyramidal Neurons in Human versus Mouse Cerebral Cortex

(2018) Brian E. Kalmbach et al.   NEURON

Large and fast human pyramidal neurons associate with intelligence

(2018) Natalia A Goriounova et al.   eLife

Structural History of Human SRGAP2 Proteins

(2017) Michael Sporny et al.   MOLECULAR BIOLOGY AND EVOLUTION

Control of species-dependent cortico-motoneuronal connections underlying manual dexterity

(2017) Zirong Gu et al.   SCIENCE

The evolution and population diversity of human-specific segmental duplications

(2017) Megan Y. Dennis et al.   Nature Ecology & Evolution

Evolution of Gene Regulation in Humans

(2016) Steven K. Reilly et al.   Annual Review of Genomics and Human Genetics

Area-Specific Features of Pyramidal Neurons—a Comparative Study in Mouse and Rhesus Monkey

(2016) Joshua P. Gilman et al.   CEREBRAL CORTEX

Structural Organization of the Laryngeal Motor Cortical Network and Its Implication for Evolution of Speech Production

(2016) V. Kumar et al.   JOURNAL OF NEUROSCIENCE

Chromosome conformation elucidates regulatory relationships in developing human brain

(2016) Hyejung Won et al.   NATURE

Evolution of Osteocrin as an activity-regulated factor in the primate brain

(2016) Bulent Ataman et al.   NATURE

Functional and structural underpinnings of neuronal assembly formation in learning

(2016) Anthony Holtmaat et al.   NATURE NEUROSCIENCE

SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses

(2016) Matteo Fossati et al.   NEURON

Variation in the molecular clock of primates

(2016) Priya Moorjani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional profiles of supragranular-enriched genes associate with corticocortical network architecture in the human brain

(2016) Fenna M. Krienen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Foxp2 Mutation Implicated in Human Speech Deficits Alters Sequencing of Ultrasonic Vocalizations in Adult Male Mice

(2016) Jonathan Chabout et al.   Frontiers in Behavioral Neuroscience

Plasticity in Single Axon Glutamatergic Connection to GABAergic Interneurons Regulates Complex Events in the Human Neocortex

(2016) Viktor Szegedi et al.   PLOS BIOLOGY

Unique membrane properties and enhanced signal processing in human neocortical neurons

(2016) Guy Eyal et al.   eLife

Human pyramidal to interneuron synapses are mediated by multi-vesicular release and multiple docked vesicles

(2016) Gábor Molnár et al.   eLife

Saturated Reconstruction of a Volume of Neocortex

(2015) Narayanan Kasthuri et al.   CELL

Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1

(2015) ChangHui Pak et al.   Cell Stem Cell

Dendritic and Axonal Architecture of Individual Pyramidal Neurons across Layers of Adult Human Neocortex

(2015) Hemanth Mohan et al.   CEREBRAL CORTEX

Human-Chimpanzee Differences in a FZD8 Enhancer Alter Cell-Cycle Dynamics in the Developing Neocortex

(2015) J. Lomax Boyd et al.   CURRENT BIOLOGY

Human-specific increase of dopaminergic innervation in a striatal region associated with speech and language: A comparative analysis of the primate basal ganglia

(2015) Mary Ann Raghanti et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function

(2015) Melissa L. Sinkus et al.   NEUROPHARMACOLOGY

The corpus callosum in primates: processing speed of axons and the evolution of hemispheric asymmetry

(2015) Kimberley A. Phillips et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion

(2015) M. Florio et al.   SCIENCE

Sperm Whales and Killer Whales with the Largest Brains of All Toothed Whales Show Extreme Differences in Cerebellum

(2014) Sam H. Ridgway et al.   BRAIN BEHAVIOR AND EVOLUTION

Comparative primate neurobiology and the evolution of brain language systems

(2014) James K. Rilling   CURRENT OPINION IN NEUROBIOLOGY

The Duplicated α7 Subunits Assemble and Form Functional Nicotinic Receptors with the Full-length α7

(2014) Ying Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Convergent differential regulation of SLIT-ROBO axon guidance genes in the brains of vocal learners

(2014) Rui Wang et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Linking Macroscale Graph Analytical Organization to Microscale Neuroarchitectonics in the Macaque Connectome

(2014) L. H. Scholtens et al.   JOURNAL OF NEUROSCIENCE

Convergent transcriptional specializations in the brains of humans and song-learning birds

(2014) A. R. Pfenning et al.   SCIENCE

Input transformation by dendritic spines of pyramidal neurons

(2014) Roberto Araya   Frontiers in Neuroanatomy

High Bandwidth Synaptic Communication and Frequency Tracking in Human Neocortex

(2014) Guilherme Testa-Silva et al.   PLOS BIOLOGY

Electrical Compartmentalization in Dendritic Spines

(2013) Rafael Yuste   Annual Review of Neuroscience

The Evolutions of Large Brain Size in Mammals: The ‘Over-700-Gram Club Quartet'

(2013) Paul R. Manger et al.   BRAIN BEHAVIOR AND EVOLUTION

Mechanisms Underlying the Rules for Associative Plasticity at Adult Human Neocortical Synapses

(2013) Matthijs B. Verhoog et al.   JOURNAL OF NEUROSCIENCE

Great ape genetic diversity and population history

(2013) Javier Prado-Martinez et al.   NATURE

Pyramidal Neurons Derived from Human Pluripotent Stem Cells Integrate Efficiently into Mouse Brain Circuits In Vivo

(2013) Ira Espuny-Camacho et al.   NEURON

A fast-evolving human NPAS3 enhancer gained reporter expression in the developing forebrain of transgenic mice

(2013) G. B. Kamm et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Synaptogenesis and development of pyramidal neuron dendritic morphology in the chimpanzee neocortex resembles humans

(2013) S. Bianchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The evolution of distributed association networks in the human brain

(2013) Randy L. Buckner et al.   TRENDS IN COGNITIVE SCIENCES

Beyond the arcuate fasciculus: consensus and controversy in the connectional anatomy of language

(2012) A. S. Dick et al.   BRAIN

Large-Scale Cellular-Resolution Gene Profiling in Human Neocortex Reveals Species-Specific Molecular Signatures

(2012) Hongkui Zeng et al.   CELL

Inhibition of SRGAP2 Function by Its Human-Specific Paralogs Induces Neoteny during Spine Maturation

(2012) Cécile Charrier et al.   CELL

Evolution of Human-Specific Neural SRGAP2 Genes by Incomplete Segmental Duplication

(2012) Megan Y. Dennis et al.   CELL

Dendritic Morphology of Pyramidal Neurons in the Chimpanzee Neocortex: Regional Specializations and Comparison to Humans

(2012) S. Bianchi et al.   CEREBRAL CORTEX

Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques

(2012) X. Liu et al.   GENOME RESEARCH

The economy of brain network organization

(2012) Ed Bullmore et al.   NATURE REVIEWS NEUROSCIENCE

Comparative Study of Human and Mouse Postsynaptic Proteomes Finds High Compositional Conservation and Abundance Differences for Key Synaptic Proteins

(2012) Àlex Bayés et al.   PLoS One

The human brain: rewired and running hot

(2011) Todd M. Preuss   Annals of the New York Academy of Sciences

Not(ch) just development: Notch signalling in the adult brain

(2011) Jessica L. Ables et al.   NATURE REVIEWS NEUROSCIENCE

Extraordinary neoteny of synaptic spines in the human prefrontal cortex

(2011) Zdravko Petanjek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Evolution of the Brain, the Human Nature of Cortical Circuits, and Intellectual Creativity

(2011) Javier DeFelipe   Frontiers in Neuroanatomy

Neuronal morphology in the African elephant (Loxodonta africana) neocortex

(2010) Bob Jacobs et al.   Brain Structure & Function

The von Economo neurons in frontoinsular and anterior cingulate cortex in great apes and humans

(2010) John M. Allman et al.   Brain Structure & Function

Regulation of synaptic connectivity by glia

(2010) Cagla Eroglu et al.   NATURE

Contrasts between adaptive coding and noncoding changes during human evolution

(2010) Ralph Haygood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neocortical layer 6, a review

(2010) Thomson   Frontiers in Neuroanatomy

Uniquely Hominid Features of Adult Human Astrocytes

(2009) N. A. Oberheim et al.   JOURNAL OF NEUROSCIENCE

Wnt Signaling in Neural Circuit Assembly

(2008) Patricia C. Salinas et al.   Annual Review of Neuroscience

An intrinsic mechanism of corticogenesis from embryonic stem cells

(2008) Nicolas Gaspard et al.   NATURE

Pyramidal neurons: dendritic structure and synaptic integration

(2008) Nelson Spruston   NATURE REVIEWS NEUROSCIENCE

Human-Specific Gain of Function in a Developmental Enhancer

(2008) S. Prabhakar et al.   SCIENCE

Complex Events Initiated by Individual Spikes in the Human Cerebral Cortex

(2008) Gábor Molnár et al.   PLOS BIOLOGY