Human Cortical Pyramidal Neurons: From Spines to Spikes via Models

Deconvolution of Voltage Sensor Time Series and Electro-diffusion Modeling Reveal the Role of Spine Geometry in Controlling Synaptic Strength

(2018) Jerome Cartailler et al.   NEURON

FIB/SEM Technology and Alzheimer's Disease: Three-Dimensional Analysis of Human Cortical Synapses

(2018) Lidia Blazquez-Llorca et al.   JOURNAL OF ALZHEIMERS DISEASE

Active dendritic integration as a mechanism for robust and precise grid cell firing

(2017) Christoph Schmidt-Hieber et al.   NATURE NEUROSCIENCE

The promise of spatial transcriptomics for neuroscience in the era of molecular cell typing

(2017) Ed Lein et al.   SCIENCE

Timed Synaptic Inhibition Shapes NMDA Spikes, Influencing Local Dendritic Processing and Global I/O Properties of Cortical Neurons

(2017) Michael Doron et al.   Cell Reports

Attenuation of Synaptic Potentials in Dendritic Spines

(2017) Taekyung Kwon et al.   Cell Reports

Big Science, Team Science, and Open Science for Neuroscience

(2016) Christof Koch et al.   NEURON

The BRAIN Initiative: Building, Strengthening, and Sustaining

(2016) Christopher L. Martin et al.   NEURON

China Brain Project: Basic Neuroscience, Brain Diseases, and Brain-Inspired Computing

(2016) Mu-ming Poo et al.   NEURON

The Human Brain Project: Creating a European Research Infrastructure to Decode the Human Brain

(2016) Katrin Amunts et al.   NEURON

Inferring cortical function in the mouse visual system through large-scale systems neuroscience

(2016) Michael Hawrylycz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active cortical dendrites modulate perception

(2016) Naoya Takahashi et al.   SCIENCE

Unique membrane properties and enhanced signal processing in human neocortical neurons

(2016) Guy Eyal et al.   eLife

Human pyramidal to interneuron synapses are mediated by multi-vesicular release and multiple docked vesicles

(2016) Gábor Molnár et al.   eLife

Reconstruction and Simulation of Neocortical Microcircuitry

(2015) Henry Markram et al.   CELL

Saturated Reconstruction of a Volume of Neocortex

(2015) Narayanan Kasthuri et al.   CELL

Dendritic and Axonal Architecture of Individual Pyramidal Neurons across Layers of Adult Human Neocortex

(2015) Hemanth Mohan et al.   CEREBRAL CORTEX

Molecular and Electrophysiological Characterization of GABAergic Interneurons Expressing the Transcription Factor COUP-TFII in the Adult Human Temporal Cortex

(2015) Csaba Varga et al.   CEREBRAL CORTEX

Electrical behaviour of dendritic spines as revealed by voltage imaging

(2015) Marko A. Popovic et al.   Nature Communications

The anatomical problem posed by brain complexity and size: a potential solution

(2015) Javier DeFelipe   Frontiers in Neuroanatomy

Dendritic Excitability and Gain Control in Recurrent Cortical Microcircuits

(2014) Etay Hay et al.   CEREBRAL CORTEX

Dendrites Impact the Encoding Capabilities of the Axon

(2014) G. Eyal et al.   JOURNAL OF NEUROSCIENCE

NMDA spikes enhance action potential generation during sensory input

(2014) Lucy M Palmer et al.   NATURE NEUROSCIENCE

Spine neck plasticity regulates compartmentalization of synapses

(2014) Jan Tønnesen et al.   NATURE NEUROSCIENCE

An Augmented Two-Layer Model Captures Nonlinear Analog Spatial Integration Effects in Pyramidal Neuron Dendrites

(2014) Monika P. Jadi et al.   PROCEEDINGS OF THE IEEE

Activity-dependent dendritic spine neck changes are correlated with synaptic strength

(2014) R. Araya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular identity of axonal sodium channels in human cortical pyramidal cells

(2014) Cuiping Tian et al.   Frontiers in Cellular Neuroscience

Generation of dense statistical connectomes from sparse morphological data

(2014) Robert Egger et al.   Frontiers in Neuroanatomy

High Bandwidth Synaptic Communication and Frequency Tracking in Human Neocortex

(2014) Guilherme Testa-Silva et al.   PLOS BIOLOGY

Glutamate-Bound NMDARs Arising from In Vivo-like Network Activity Extend Spatio-temporal Integration in a L5 Cortical Pyramidal Cell Model

(2014) Matteo Farinella et al.   PLoS Computational Biology

Active Properties of Neocortical Pyramidal Neuron Dendrites

(2013) Guy Major et al.   Annual Review of Neuroscience

Contribution of Intracolumnar Layer 2/3-to-Layer 2/3 Excitatory Connections in Shaping the Response to Whisker Deflection in Rat Barrel Cortex

(2013) L. Sarid et al.   CEREBRAL CORTEX

Preserving axosomatic spiking features despite diverse dendritic morphology

(2013) Etay Hay et al.   JOURNAL OF NEUROPHYSIOLOGY

Mechanisms Underlying the Rules for Associative Plasticity at Adult Human Neocortical Synapses

(2013) Matthijs B. Verhoog et al.   JOURNAL OF NEUROSCIENCE

Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo

(2013) Spencer L. Smith et al.   NATURE

Age-Based Comparison of Human Dendritic Spine Structure Using Complete Three-Dimensional Reconstructions

(2012) Ruth Benavides-Piccione et al.   CEREBRAL CORTEX

Synaptic amplification by dendritic spines enhances input cooperativity

(2012) Mark T. Harnett et al.   NATURE

Nonlinear dendritic processing determines angular tuning of barrel cortex neurons in vivo

(2012) Maria Lavzin et al.   NATURE

Signal Processing in the Axon Initial Segment

(2012) Maarten H.P. Kole et al.   NEURON

Models of Neocortical Layer 5b Pyramidal Cells Capturing a Wide Range of Dendritic and Perisomatic Active Properties

(2011) Etay Hay et al.   PLoS Computational Biology

Channelpedia: An Integrative and Interactive Database for Ion Channels

(2011) Rajnish Ranjan et al.   Frontiers in Neuroinformatics

Membrane Potential Changes in Dendritic Spines during Action Potentials and Synaptic Input

(2009) L. M. Palmer et al.   JOURNAL OF NEUROSCIENCE

Synaptic Integration in Tuft Dendrites of Layer 5 Pyramidal Neurons: A New Unifying Principle

(2009) M. E. Larkum et al.   SCIENCE

Pyramidal neurons: dendritic structure and synaptic integration

(2008) Nelson Spruston   NATURE REVIEWS NEUROSCIENCE

Gender differences in human cortical synaptic density

(2008) L. Alonso-Nanclares et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA