Silencing of Unintegrated Retroviral DNAs

Cone-shaped HIV-1 capsids are transported through intact nuclear pores

(2021) Vojtech Zila et al.   CELL

HIV-1 cores retain their integrity until minutes before uncoating in the nucleus

(2021) Chenglei Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr

(2021) Liane Dupont et al.   Cell Host & Microbe

Tax induces the recruitment of NF-kB to unintegrated HIV-1 DNA to rescue viral gene expression and replication

(2021) Ishak D. Irwan et al.   JOURNAL OF VIROLOGY

Moloney murine leukemia virus p12 is required for histone loading onto retroviral DNAs

(2021) Gary Z. Wang et al.   JOURNAL OF VIROLOGY

ATRX limits the accessibility of histone H3-occupied HSV genomes during lytic infection

(2021) Joseph M. Cabral et al.   PLoS Pathogens

HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells

(2021) Thorsten G Müller et al.   eLife

HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration

(2021) Anabel Guedán et al.   PLoS Pathogens

HIV-1 uncoats in the nucleus near sites of integration

(2020) Ryan C. Burdick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploring histone loading on HIV DNA reveals a dynamic nucleosome positioning between unintegrated and integrated viral genome

(2020) Shinichi Machida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversal of Epigenetic Silencing Allows Robust HIV-1 Replication in the Absence of Integrase Function

(2020) Ishak D. Irwan et al.   mBio

Nuclear pore blockade reveals that HIV-1 completes reverse transcription and uncoating in the nucleus

(2020) Adarsh Dharan et al.   Nature Microbiology

Epigenetic and epitranscriptomic regulation of viral replication

(2020) Kevin Tsai et al.   NATURE REVIEWS MICROBIOLOGY

Mutations altering acetylated residues in the CTD of HIV-1 integrase cause defects in proviral transcription at early times after integration of viral DNA

(2020) Shelby Winans et al.   PLoS Pathogens

Cytosolic DNA-sensing immune response and viral infection

(2019) Takayuki Abe et al.   MICROBIOLOGY AND IMMUNOLOGY

Unintegrated HIV-1 DNAs are loaded with core and linker histones and transcriptionally silenced

(2019) Franziska K. Geis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes

(2018) Luisa Robbez-Masson et al.   GENOME RESEARCH

Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis

(2018) Madushi Wanaguru et al.   PLoS Pathogens

NP220 mediates silencing of unintegrated retroviral DNA

(2018) Yiping Zhu et al.   NATURE

Elsässer et al. reply

(2017) Simon J. Elsässer et al.   NATURE

On the role of H3.3 in retroviral silencing

(2017) Gernot Wolf et al.   NATURE

How histones go viral

(2017) Katharine H. Wrighton   NATURE REVIEWS MICROBIOLOGY

Histones Are Rapidly Loaded onto Unintegrated Retroviral DNAs Soon after Nuclear Entry

(2016) Gary Z. Wang et al.   Cell Host & Microbe

Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor

(2016) Adrien Decorsière et al.   NATURE

Position effects influence HIV latency reversal

(2016) Heng-Chang Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma—A Tale of Two Proteins: Tax and HBZ

(2016) Chou-Zen Giam et al.   Viruses-Basel

Position effects influence HIV latency reversal

(2016) Heng-Chang Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication

(2016) Christopher M. Murphy et al.   Cell Reports

Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells

(2015) Bin Xia Yang et al.   CELL

The Road Less Traveled: HIV's Use of Alternative Routes through Cellular Pathways

(2015) Ailie Marx et al.   JOURNAL OF VIROLOGY

Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells

(2015) Simon J. Elsässer et al.   NATURE

Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells

(2015) I. A. Tchasovnikarova et al.   SCIENCE

Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

(2015) M. Raschle et al.   SCIENCE

Nuclear sensing of viral DNA, epigenetic regulation of herpes simplex virus infection, and innate immunity

(2015) David M. Knipe   VIROLOGY

Postentry Restriction of Mason-Pfizer Monkey Virus in Mouse Cells

(2014) Gary Z. Wang et al.   JOURNAL OF VIROLOGY

50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond

(2014) Eric Verdin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Viral DNA tethering domains complement replication-defective mutations in the p12 protein of MuLV Gag

(2013) William M. Schneider et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proviral Silencing in Embryonic Cells Is Regulated by Yin Yang 1

(2013) Sharon Schlesinger et al.   Cell Reports

p12 Tethers the Murine Leukemia Virus Pre-integration Complex to Mitotic Chromosomes

(2013) Efrat Elis et al.   PLoS Pathogens

Retroviral DNA Methylation and Epigenetic Repression Are Mediated by the Antiviral Host Protein Daxx

(2012) N. Shalginskikh et al.   JOURNAL OF VIROLOGY

MuLV IN mutants responsive to HDAC inhibitors enhance transcription from unintegrated retroviral DNA

(2012) William M. Schneider et al.   VIROLOGY

Cytoplasmic DNA innate immune pathways

(2011) Glen N. Barber   IMMUNOLOGICAL REVIEWS

Epigenetic regulation of HIV-1 transcription

(2011) Manoj Kumar Tripathy et al.   Epigenomics

Flexible Use of Nuclear Import Pathways by HIV-1

(2010) KyeongEun Lee et al.   Cell Host & Microbe

KAP1 controls endogenous retroviruses in embryonic stem cells

(2010) Helen M. Rowe et al.   NATURE

Dynamic instability of genomic methylation patterns in pluripotent stem cells

(2010) Steen KT Ooi et al.   Epigenetics & Chromatin

Chromatin assembly on herpes simplex virus genomes during lytic infection

(2009) Xu Lu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Herpes Simplex Virus VP16, but Not ICP0, Is Required To Reduce Histone Occupancy and Enhance Histone Acetylation on Viral Genomes in U2OS Osteosarcoma Cells

(2009) M. H. Hancock et al.   JOURNAL OF VIROLOGY

Embryonic stem cells use ZFP809 to silence retroviral DNAs

(2009) Daniel Wolf et al.   NATURE

Herpes Simplex Virus ICP0 Promotes both Histone Removal and Acetylation on Viral DNA during Lytic Infection

(2008) A. R. Cliffe et al.   JOURNAL OF VIROLOGY