Peptide–drug conjugate-based novel molecular drug delivery system in cancer
Published 2021 View Full Article
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Title
Peptide–drug conjugate-based novel molecular drug delivery system in cancer
Authors
Keywords
molecular drug delivery system, peptide–drug conjugates, tumor targeting peptides, payloads, receptors
Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 42, Issue 10, Pages 857-869
Publisher
Elsevier BV
Online
2021-07-30
DOI
10.1016/j.tips.2021.07.001
References
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Note: Only part of the references are listed.- Peptide–Drug Conjugates with Different Linkers for Cancer Therapy
- (2021) Mona Alas et al. JOURNAL OF MEDICINAL CHEMISTRY
- Development of a LC–MS/MS method for the quantification of toxic payload DM1 cleaved from BT1718 in a Phase I study
- (2021) Catherine Gowland et al. Bioanalysis
- Tumor-penetrating therapy for β5 integrin-rich pancreas cancer
- (2021) Tatiana Hurtado de Mendoza et al. Nature Communications
- Reappraisal of anticancer nanomedicine design criteria in three types of preclinical cancer models for better clinical translation
- (2021) Xin Luan et al. BIOMATERIALS
- Converting peptides into drugs targeting intracellular protein–protein interactions
- (2021) Grégoire J.B. Philippe et al. DRUG DISCOVERY TODAY
- Small-sized gadolinium oxide based nanoparticles for high-efficiency theranostics of orthotopic glioblastoma
- (2020) Zheyu Shen et al. BIOMATERIALS
- Cancer statistics, 2020
- (2020) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- ANG1005, a brain penetrating peptide-drug conjugate, shows activity in patients with breast cancer with leptomeningeal carcinomatosis and recurrent brain metastases
- (2020) Priya Kumthekar et al. CLINICAL CANCER RESEARCH
- Multiple Myeloma: Available Therapies and Causes of Drug Resistance
- (2020) Vanessa Pinto et al. Cancers
- Problem of Diminished cRGD Surface Activity and What Can Be Done about It
- (2020) Michael C. Robitaille et al. ACS Applied Materials & Interfaces
- BT5528-100 phase I/II study of the safety, pharmacokinetics, and preliminary clinical activity of BT5528 in patients with advanced malignancies associated with EphA2 expression.
- (2020) Johanna C. Bendell et al. JOURNAL OF CLINICAL ONCOLOGY
- Identification and Optimization of EphA2-Selective Bicycles for the Delivery of Cytotoxic Payloads
- (2020) Gemma E. Mudd et al. JOURNAL OF MEDICINAL CHEMISTRY
- MMAE delivery using the Bicycle toxin conjugate BT5528
- (2020) Gavin Bennett et al. MOLECULAR CANCER THERAPEUTICS
- Multispecific drugs herald a new era of biopharmaceutical innovation
- (2020) Raymond J. Deshaies NATURE
- Melflufen plus dexamethasone in relapsed and refractory multiple myeloma (O-12-M1): a multicentre, international, open-label, phase 1–2 study
- (2020) Paul G Richardson et al. Lancet Haematology
- Design of integrin αvβ3 targeting self-assembled protein nanoparticles with RGD peptide
- (2020) Xiangfeng Lv et al. BIOMEDICINE & PHARMACOTHERAPY
- [18F]AlF-NOTA-octreotide PET imaging: biodistribution, dosimetry and first comparison with [68Ga]Ga-DOTATATE in neuroendocrine tumour patients
- (2020) Elin Pauwels et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Peptide-Drug Conjugates and Their Targets in Advanced Cancer Therapies
- (2020) Paul Hoppenz et al. Frontiers in Chemistry
- 177Lu-DOTATATE therapy in metastatic/inoperable pheochromocytoma-paraganglioma
- (2020) Sanjeet Kumar Jaiswal et al. Endocrine Connections
- First-In-Class CD13-Targeted Tissue Factor tTF-NGR in Patients with Recurrent or Refractory Malignant Tumors: Results of a Phase I Dose-Escalation Study
- (2020) Christoph Schliemann et al. Cancers
- Tumour sensitization via the extended intratumoural release of a STING agonist and camptothecin from a self-assembled hydrogel
- (2020) Feihu Wang et al. Nature Biomedical Engineering
- Maintenance of Acromegaly Control in Patients Switching From Injectable Somatostatin Receptor Ligands to Oral Octreotide
- (2020) Susan L Samson et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- An enumerative algorithm for de novo design of proteins with diverse pocket structures
- (2020) Benjamin Basanta et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Shortened Tracer Uptake Time in GA-68-DOTATOC-PET of Meningiomas Does Not Impair Diagnostic Accuracy and PET Volume Definition
- (2020) Josefine Graef et al. Diagnostics
- Cell penetrating peptides: A versatile vector for co-delivery of drug and genes in cancer
- (2020) Muhammad Muzamil Khan et al. JOURNAL OF CONTROLLED RELEASE
- MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms
- (2019) Valentina Gifford et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- A Phase II, Multicenter, Single-Arm Study of Mipsagargin (G-202) as a Second-Line Therapy Following Sorafenib for Adult Patients with Progressive Advanced Hepatocellular Carcinoma
- (2019) Devalingam Mahalingam et al. Cancers
- Mechanism of Action of the Tumor Vessel Targeting Agent NGR-hTNF: Role of Both NGR Peptide and hTNF in Cell Binding and Signaling
- (2019) Barbara Valentinis et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Clinical Activity of Melflufen in Patients with Triple-Class Refractory Multiple Myeloma and Poor-Risk Features in an Updated Analysis of HORIZON (OP-106), a Phase 2 Study in Patients with Relapsed/Refractory Multiple Myeloma Refractory to Pomalidomide and/or Daratumumab
- (2019) María-Victoria Mateos et al. BLOOD
- Availability of both [177Lu]Lu-DOTA-TATE and [90Y]Y-DOTATATE as PRRT agents for neuroendocrine tumors: can we evolve a rational sequential duo-PRRT protocol for large volume resistant tumors?
- (2019) Sandip Basu et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer
- (2019) Kerry A. Whalen et al. MOLECULAR CANCER THERAPEUTICS
- 177Lu-DOTATATE for the treatment of gastroenteropancreatic neuroendocrine tumors
- (2019) Satya Das et al. Expert Review of Gastroenterology & Hepatology
- Radiolabeling nanomaterials for multimodality imaging: New insights into nuclear medicine and cancer diagnosis
- (2019) Jianxian Ge et al. BIOMATERIALS
- Independent control of matrix adhesiveness and stiffness within a 3D self-assembling peptide hydrogel
- (2018) Nathaniel J. Hogrebe et al. Acta Biomaterialia
- Peptide-based nanoprobes for molecular imaging and disease diagnostics
- (2018) Pengcheng Zhang et al. CHEMICAL SOCIETY REVIEWS
- Nanoparticle transport pathways into tumors
- (2018) S. M. Moghimi et al. JOURNAL OF NANOPARTICLE RESEARCH
- NGR-hTNF in combination with best investigator choice in previously treated malignant pleural mesothelioma (NGR015): a randomised, double-blind, placebo-controlled phase 3 trial
- (2018) Vanesa Gregorc et al. LANCET ONCOLOGY
- Comparison and evaluation of two RGD peptides labelled with 68Ga or 18F for PET imaging of angiogenesis in animal models of human glioblastoma or lung carcinoma
- (2018) Claire Provost et al. Oncotarget
- Oral peptide delivery: Translational challenges due to physiological effects
- (2018) Puneet Tyagi et al. JOURNAL OF CONTROLLED RELEASE
- Synthesis and In Vitro Study of a Dual-Mode Probe Targeting Integrin αvβ3
- (2018) Yali Zhang et al. Nanoscale Research Letters
- Safety and Pharmacokinetics of Single and Multiple Ascending Doses of the Novel Oral Human GLP-1 Analogue, Oral Semaglutide, in Healthy Subjects and Subjects with Type 2 Diabetes
- (2018) Charlotte Granhall et al. CLINICAL PHARMACOKINETICS
- Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides
- (2017) Shama Dissanayake et al. JOURNAL OF CONTROLLED RELEASE
- Phase 3 Trial of 177Lu-Dotatate for Midgut Neuroendocrine Tumors
- (2017) Jonathan Strosberg et al. NEW ENGLAND JOURNAL OF MEDICINE
- Integrin-targeted peptide- and peptidomimetic-drug conjugates for the treatment of tumors
- (2017) Daniela Arosio et al. Recent Patents on Anti-Cancer Drug Discovery
- Melflufen - a peptidase-potentiated alkylating agent in clinical trials
- (2017) Malin Wickström et al. Oncotarget
- Exploring the Role of RGD-Recognizing Integrins in Cancer
- (2017) Markus Nieberler et al. Cancers
- Mipsagargin, a novel thapsigargin-based PSMA-activated prodrug: results of a first-in-man phase I clinical trial in patients with refractory, advanced or metastatic solid tumours
- (2016) D Mahalingam et al. BRITISH JOURNAL OF CANCER
- [68Ga]NODAGA-RGD – Metabolic stability, biodistribution, and dosimetry data from patients with hepatocellular carcinoma and liver cirrhosis
- (2016) Roland Haubner et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Safety and Efficacy of 68Ga-DOTATATE PET/CT for Diagnosis, Staging, and Treatment Management of Neuroendocrine Tumors
- (2016) S. A. Deppen et al. JOURNAL OF NUCLEAR MEDICINE
- Multicenter Reproducibility of 18F-Fluciclatide PET Imaging in Subjects with Solid Tumors
- (2015) R. Sharma et al. JOURNAL OF NUCLEAR MEDICINE
- Acid-Sensitive Peptide-Conjugated Doxorubicin Mediates the Lysosomal Pathway of Apoptosis and Reverses Drug Resistance in Breast Cancer
- (2015) Yuan Sheng et al. MOLECULAR PHARMACEUTICS
- Somatostatin Receptor Imaging with68Ga DOTATATE PET/CT: Clinical Utility, Normal Patterns, Pearls, and Pitfalls in Interpretation
- (2015) Michael S. Hofman et al. RADIOGRAPHICS
- A Unified Mechanism for Aminopeptidase N-based Tumor Cell Motility and Tumor-homing Therapy
- (2014) Chang Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance
- (2014) Hariharan Easwaran et al. MOLECULAR CELL
- Phase I Study of GRN1005 in Recurrent Malignant Glioma
- (2013) J. Drappatz et al. CLINICAL CANCER RESEARCH
- Comparison of two new angiogenesis PET tracers 68Ga-NODAGA-E[c(RGDyK)]2 and 64Cu-NODAGA-E[c(RGDyK)]2; in vivo imaging studies in human xenograft tumors
- (2013) Jytte Oxboel et al. NUCLEAR MEDICINE AND BIOLOGY
- 99mTc-Tektrotyd SPECT/MRI in the Diagnosis of a Gastroenteropancreatic Neuroendocrine Tumor
- (2012) Shahin Zandieh et al. CLINICAL NUCLEAR MEDICINE
- Biodistribution and Radiation Dosimetry of the Integrin Marker 18F-RGD-K5 Determined from Whole-Body PET/CT in Monkeys and Humans
- (2012) M. Doss et al. JOURNAL OF NUCLEAR MEDICINE
- Structural basis for multifunctional roles of mammalian aminopeptidase N
- (2012) L. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The alkylating prodrug J1 can be activated by aminopeptidase N, leading to a possible target directed release of melphalan
- (2010) Malin Wickström et al. BIOCHEMICAL PHARMACOLOGY
- Left-Handed Dimer of EphA2 Transmembrane Domain: Helix Packing Diversity among Receptor Tyrosine Kinases
- (2010) Eduard V. Bocharov et al. BIOPHYSICAL JOURNAL
- The Dimer Interface of the Membrane Type 1 Matrix Metalloproteinase Hemopexin Domain
- (2010) Anna Tochowicz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure of the Minimal Interface Between ApoE and LRP
- (2010) Miklos Guttman et al. JOURNAL OF MOLECULAR BIOLOGY
- A Remote Arene-Binding Site on Prostate Specific Membrane Antigen Revealed by Antibody-Recruiting Small Molecules
- (2010) Andrew X. Zhang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Somatostatin Receptor-Targeted Anti-Cancer Therapy
- (2010) Li-Chun Sun et al. Current Drug Delivery
- Functional imaging in differentiating bronchial masses: an initial experience with a combination of 18F-FDG PET-CT scan and 68Ga DOTA-TOC PET-CT scan
- (2009) Arvind Kumar et al. ANNALS OF NUCLEAR MEDICINE
- Infarction of tumor vessels by NGR-peptide-directed targeting of tissue factor: experimental results and first-in-man experience
- (2009) R. Bieker et al. BLOOD
- 68Ga-labeled NOTA-RGD-BBN peptide for dual integrin and GRPR-targeted tumor imaging
- (2009) Zhaofei Liu et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Phase I Trial of the Positron-Emitting Arg-Gly-Asp (RGD) Peptide Radioligand 18F-AH111585 in Breast Cancer Patients
- (2008) L. M. Kenny et al. JOURNAL OF NUCLEAR MEDICINE
- Imaging in the era of molecular oncology
- (2008) Ralph Weissleder et al. NATURE
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