Article
Chemistry, Medicinal
Saghar Mozaffari, David Salehi, Parvin Mahdipoor, Richard Beuttler, Rakesh Tiwari, Hamidreza Montazeri Aliabadi, Keykavous Parang
Summary: The hybrid cyclic-linear [R5K]W(7)A-Dox conjugate showed significant efficacy in inhibiting cancer cell proliferation with minimal toxicity to normal cells, compared to free Dox. It also exhibited higher efficiency in Dox-resistant cells when compared to free Dox.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Liming Gong, Heming Zhao, Yanhong Liu, Hao Wu, Chao Liu, Shuangyan Chang, Liqing Chen, Mingji Jin, Qiming Wang, Zhonggao Gao, Wei Huang
Summary: Peptide-drug conjugates (PDCs) are drug delivery systems that combine drugs with peptides using cleavable linkers. They improve drug stability and targeting, while reducing toxic side effects. PDCs have been widely used in drug delivery.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Oncology
Mo Wu, Wei Huang, Nan Yang, Yanyong Liu
Summary: Chemotherapy is criticized for its non-selective toxicity and drug resistance. Combination therapy, such as drug conjugates, has been developed to improve clinical efficacy. Compared to antibody-drug conjugates, peptide-drug conjugates have advantages but also face limitations in development.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Article
Materials Science, Biomaterials
Lijie Li, Qi Zhan, Kaikai Yi, Ning Chen, Xueping Li, Shixue Yang, Xin Hou, Jin Zhao, Xubo Yuan, Chunsheng Kang
Summary: By engineering liposomes with lysophosphatidylcholine (LPC), the cellular uptake efficiency of liposomes was improved, leading to enhanced antitumor activity. In animal experiments, LPC-engineered liposomes showed better tumor growth inhibition without significant side effects.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Biochemistry & Molecular Biology
Atsushi Tamura, Mamoru Osawa, Nobuhiko Yui
Summary: Doxorubicin (DOX)-conjugated acid-degradable polyrotaxanes (PRXs) were designed as supramolecular drug carriers that release drug-modified alpha-cyclodextrins (alpha-CDs) in acidic cellular environments. The acid-induced cleavage of acid-labile stopper molecules in PRXs leads to PRX dissociation and the release of DOX-modified alpha-CDs under acidic conditions. The DOX-conjugated PRXs showed significant cytotoxicity in colon-26 cells and the released DOX-modified alpha-CDs accumulated in cellular nuclei. Acid-degradable PRXs represent a promising framework for pH-responsive drug carriers, contributing to the development of cancer therapies.
Article
Biochemistry & Molecular Biology
Yuting Yuan, Zhenhua Wang, Shengjia Su, Yingqi Mi, Qing Li, Fang Dong, Wenqiang Tan, Zhanyong Guo
Summary: Amphiphilic low molecular weight chitosan-lipoic acid (LC-LA) conjugates with different degrees of substitution (DS) of LA were synthesized by N, N'-carbonyldiimidazole (CDI) catalysis to self-assemble into redox-sensitive micelles. The blank micelles showed excellent biocompatibility and redox-sensitive behavior with low critical micelle concentration (CMC), nano-scale size, and positive zeta potential. Doxorubicin (Dox) loaded micelles exhibited redox-trigger behavior, strong antitumor activity, and increased cellular uptake efficiency against A549 cell.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Jiaojiao Chen, Yarong Song, Wenqian Yang, Jianhui Guo, Saihui Zhang, Dong Wan, Yonghui Liu, Jie Pan
Summary: In this study, tumor-targeted polymeric micelles were synthesized, and drug release was achieved through extracellular enzyme response and intracellular reduction response, thereby improving the disadvantages of chemotherapy drugs. The experiments demonstrated that this method had good anti-tumor activity in vivo and reduced toxic side effects on normal tissues.
ACS APPLIED NANO MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Vivek P. Chavda, Hetvi K. Solanki, Majid Davidson, Vasso Apostolopoulos, Joanna Bojarska
Summary: Cancer remains the leading cause of death worldwide, and safe and effective therapeutics are needed. Short peptides offer advantages in cancer management due to their unique properties, versatility, and progress in biotechnology. Peptide conjugates, as the next generation of drugs, provide precise targeting, enhanced cellular permeability, improved drug selectivity, and reduced toxicity for efficient cancer treatment.
Article
Chemistry, Multidisciplinary
Xiunan Yu, Hao Wang, Xin Liu, Le Huang, Na Song, Yanqiu Song, Xiaowei Mo, Shaofeng Lou, Linqi Shi, Zhilin Yu
Summary: This study reports the assembly of synergistic peptide-drug conjugates for the treatment of cancer metastasis. The conjugates were created by co-assembling a protein-derived therapeutic peptide with paclitaxel, resulting in remarkable therapeutic effects and tumor-targeting properties.
Article
Pharmacology & Pharmacy
Su Jeong Song, Joon Sig Choi
Summary: Self-assembled peptide nanostructures are gaining attention as drug delivery systems due to their enhanced biocompatibility and biodegradability compared to polymer-based carriers. In this study, an enzyme-responsive peptide nanoparticle system was introduced, which showed effective controlled release of cargo molecules. The system exhibited good cellular uptake and biocompatibility, and demonstrated superior anticancer effects compared to the control groups.
Article
Multidisciplinary Sciences
Vinu Krishnan, Kevin Peng, Apoorva Sarode, Supriya Prakash, Zongmin Zhao, Sergey K. Filippov, Kristina Todorova, Brittney R. Sell, Omar Lujano, Shirin Bakre, Anusha Pusuluri, Douglas Vogus, Kenneth Y. Tsai, Anna Mandinova, Samir Mitragotri
Summary: DOCTOR is a novel topical treatment for skin cancer that demonstrates high cancer-cell killing specificity and superior safety to healthy skin cells compared to conventional treatments. In vivo and ex vivo studies confirm its efficacy in treating cancerous lesions without irritation or systemic absorption, making it a safe and potent option for clinical use.
Article
Nanoscience & Nanotechnology
Yan Tan, Yingying Li, Yi-Xin Qu, Yuanye Su, Yongbo Peng, Zilong Zhao, Ting Fu, Xue-Qiang Wang, Weihong Tan
Summary: The study discusses the design and development of anti-MUC1 aptamer-peptide conjugates as targeted chemosensitizers to overcome issues related to high levels of HSP70 in tumors. This innovative conjugate not only enhances the sensitivity of DOX-resistant cells but also alleviates DOX-induced cardiotoxicity, highlighting the success of this targeted chemosensitizer strategy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Jong-Ryul Park, Anthony D. Verderosa, Makrina Totsika, Richard Hoogenboom, Tim R. Dargaville
Summary: The polymer-antibiotic conjugate has thermoresponsive properties near body temperature, allowing for localized antibiotic delivery and efficient clearance of Escherichia coli within 12 hours.
Article
Chemistry, Multidisciplinary
Rui Sun, Yifan Zhang, Xiaowei Lin, Ying Piao, Tao Xie, Yi He, Jiajia Xiang, Shiqun Shao, Quan Zhou, Zhuxian Zhou, Jianbin Tang, Youqing Shen
Summary: Tumor enzyme-responsive charge-reversal carriers have the potential to effectively infiltrate tumors and deliver anticancer drugs. This study investigates the correlations between molecular structure, charge-reversal property, tumor penetration, and drug delivery efficiency. The findings show that the structure of the monomeric unit and polymer chain determines the enzymatic hydrolysis and charge-reversal rates, which subsequently impact the transcytosis and tumor accumulation of the carriers. The conjugate with moderate APN responsiveness exhibits the best tumor delivery efficiency and demonstrates potent antitumor efficacy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Medicine, Research & Experimental
Carolina Henriques Cavalcante, Renata Salgado Fernandes, Juliana de Oliveira Silva, Caroline Mari Ramos Oda, Elaine Amaral Leite, Geovanni Dantas Cassali, Ives Charlie-Silva, Bianca Helena Ventura Fernandes, Lucas Antonio Miranda Ferreira, Andre Luis Branco de Barros
Summary: The developed pH-sensitive micelles encapsulating DOX showed promising results with small diameter, high stability, low toxicity, and significantly better inhibition of tumor growth compared to other forms of DOX.
BIOMEDICINE & PHARMACOTHERAPY
(2021)