ER stress in obesity pathogenesis and management

Maternal obesity during pregnancy leads to adipose tissue ER stress in mice via miR-126-mediated reduction in Lunapark

(2021) Juliana de Almeida-Faria et al.   DIABETOLOGIA

ER stress in Cardiometabolic Diseases: from Molecular Mechanisms to Therapeutics

(2021) Amir Ajoolabady et al.   ENDOCRINE REVIEWS

Flavonoid consumption and cardiometabolic health: Potential benefits due to foods, supplements, or biomarkers?

(2021) Simin Liu et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Targeting autophagy in neurodegenerative diseases: From molecular mechanisms to clinical therapeutics

(2021) Amir Ajoolabady et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Ferritinophagy and ferroptosis in the management of metabolic diseases

(2021) Amir Ajoolabady et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

FUNDC1 insufficiency sensitizes high fat diet intake-induced cardiac remodeling and contractile anomaly through ACSL4-mediated ferroptosis

(2021) Zhaohui Pei et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics

(2021) Amir Ajoolabady et al.   PHARMACOLOGY & THERAPEUTICS

Isopulegol, A Dietary Monoterpene Mitigates Hyperglycemia Mediated Oxidative and Endoplasmic Reticulum Stress in HFD/STZ Induced Diabetic Rats

(2020) Chandrasekaran Sankaranarayanan et al.   ARCHIVES OF MEDICAL RESEARCH

Telmisartan attenuates obesity-induced insulin resistance via suppression of AMPK mediated ER stress

(2020) Ya Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MANF Promotes Diabetic Corneal Epithelial Wound Healing and Nerve Regeneration by Attenuating Hyperglycemia-Induced Endoplasmic Reticulum Stress

(2020) Xiaochuan Wang et al.   DIABETES

The Oligomerization Status of IRE1α Kinase/RNase Determines Its Signaling Outputs Under Endoplasmic Reticulum Stress

(2020) Scott A. Oakes   FASEB JOURNAL

Peroxiredoxin 4 inhibits insulin-induced adipogenesis through regulation of ER stress in 3T3-L1 cells

(2020) Jae Yeop Kim et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mechanisms, regulation and functions of the unfolded protein response

(2020) Claudio Hetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondria and T2D: Role of Autophagy, ER Stress, and Inflammasome

(2020) Milagros Rocha et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates

(2020) Soyoung Park et al.   Nature Communications

Exercise and Curcumin in Combination Improves Cognitive Function and Attenuates ER Stress in Diabetic Rats

(2020) Jin Ah Cho et al.   Nutrients

Maternal obesity-induced endoplasmic reticulum stress causes metabolic alterations and abnormal hypothalamic development in the offspring

(2020) Soyoung Park et al.   PLOS BIOLOGY

Swimming Differentially Affects T2DM-Induced Skeletal Muscle ER Stress and Mitochondrial Dysfunction Related to MAM

(2020) Zhe Zhang et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Enzyme-based autophagy in anti-neoplastic management: From molecular mechanisms to clinical therapeutics

(2020) Amir Ajoolabady et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

1980-P: Broccoli Extract as a Supplement to Mitigate ER-Induced Inflammation in Adipocytes to Reduce Type 2 Diabetes Mellitus Risk

(2020) ALICE MURPHY et al.   DIABETES

Liraglutide protects pancreatic β cells from endoplasmic reticulum stress by upregulating MANF to promote autophagy turnover

(2020) Jili Fu et al.   LIFE SCIENCES

SHQ1 is an ER stress response gene that facilitates chemotherapeutics-induced apoptosis via sensitizing ER-stress response

(2020) Huimin Liu et al.   Cell Death & Disease

In vitro treatment of 3 T3-L1 adipocytes with recombinant Calcium/calmodulin-dependent Protein Kinase IV (CaMKIV) limits ER stress and improves insulin sensitivity through inhibition of autophagy via the mTOR/CREB signaling pathway

(2020) Jiali Liu et al.   BMC Endocrine Disorders

3β-Hydroxysteroid-Δ24 Reductase (DHCR24) Protects Pancreatic β Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Scavenging Excessive Intracellular Reactive Oxygen Species

(2020) Yang Li et al.   Journal of Diabetes Research

Mitophagy Receptors and Mediators: Therapeutic Targets in the Management of Cardiovascular Ageing

(2020) Amir Ajoolabady et al.   AGEING RESEARCH REVIEWS

Berberine ameliorates obesity-induced chronic inflammation through suppression of ER stress and promotion of macrophage M2 polarization at least partly via downregulating lncRNA Gomafu

(2020) Yu-Bo Han et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ginsenoside Mc1 improves liver steatosis and insulin resistance by attenuating ER stress

(2020) Eun Roh et al.   JOURNAL OF ETHNOPHARMACOLOGY

FUNDC1 interacts with FBXL2 to govern mitochondrial integrity and cardiac function through an IP3R3-dependent manner in obesity

(2020) Jun Ren et al.   Science Advances

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism

(2020) Amir Tirosh et al.   Cell Metabolism

Phosphorylation of eIF2α signaling pathway attenuates obesity-induced non-alcoholic fatty liver disease in an ER stress and autophagy-dependent manner

(2020) Jie Li et al.   Cell Death & Disease

The Complex Interactions Between Obesity, Metabolism and the Brain

(2019) Romina María Uranga et al.   Frontiers in Neuroscience

Role of ghrelin isoforms in the mitigation of hepatic inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress after bariatric surgery in rats

(2019) S. Ezquerro et al.   INTERNATIONAL JOURNAL OF OBESITY

Resveratrol Treatment in Patients with Polycystic Ovary Syndrome Decreased Pro‐inflammatory and Endoplasmic Reticulum Stress Markers

(2019) Samaneh Brenjian et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Vitamin D receptor activation in liver macrophages protects against hepatic endoplasmic reticulum stress in mice

(2019) Ying Zhou et al.   HEPATOLOGY

Hoxa5 alleviates obesity‐induced chronic inflammation by reducing ER stress and promoting M2 macrophage polarization in mouse adipose tissue

(2019) Weina Cao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Aberrant ER-stress induced neuronal-IFNβ elicits white matter injury due to microglial activation and T-cell infiltration after TBI

(2019) Tanusree Sen et al.   JOURNAL OF NEUROSCIENCE

Beneficial effect of ER stress preconditioning in protection against FFA-induced adipocyte inflammation via XBP1 in 3T3-L1 adipocytes

(2019) Min Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition

(2019) Longjun Li et al.   CELL DEATH AND DIFFERENTIATION

NK cells induce hepatic ER stress to promote insulin resistance in obesity through osteopontin production

(2019) Junhua Wu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

AMPK alleviates endoplasmic reticulum stress by inducing the ER-chaperone ORP150 via FOXO1 to protect human bronchial cells from apoptosis

(2018) Ji-qiang Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications

(2018) Aitor Almanza et al.   FEBS Journal

A genetic variant in SLC30A2 causes breast dysfunction during lactation by inducing ER stress, oxidative stress and epithelial barrier defects

(2018) Sooyeon Lee et al.   Scientific Reports

Mechanism of Action of Magnesium Lithospermate B against Aging and Obesity-Induced ER Stress, Insulin Resistance, and Inflammsome Formation in the Liver

(2018) Ji Jeong et al.   MOLECULES

PDK4 Augments ER-Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity

(2018) Themis Thoudam et al.   DIABETES

Moderate weight loss attenuates chronic endoplasmic reticulum stress and mitochondrial dysfunction in human obesity

(2018) Sandra López-Domènech et al.   Molecular Metabolism

Endoplasmic Reticulum (ER) Stress and Endocrine Disorders

(2017) Daisuke Ariyasu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Curcumin limits weight gain, adipose tissue growth, and glucose intolerance following the cessation of exercise and caloric restriction in rats

(2017) Trevor Teich et al.   JOURNAL OF APPLIED PHYSIOLOGY

Uromodulin p.Cys147Trp mutation drives kidney disease by activating ER stress and apoptosis

(2017) Bryce G. Johnson et al.   JOURNAL OF CLINICAL INVESTIGATION

The formation and function of ER-endosome membrane contact sites

(2016) Emily R. Eden   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The signaling mechanisms of hippocampal endoplasmic reticulum stress affecting neuronal plasticity-related protein levels in high fat diet-induced obese rats and the regulation of aerobic exercise

(2016) Ming Cai et al.   BRAIN BEHAVIOR AND IMMUNITY

Physical exercise alleviates ER stress in obese humans through reduction in the expression and release of GRP78 chaperone

(2016) Abdelkrim Khadir et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Calorie-induced ER stress suppresses uroguanylin satiety signaling in diet-induced obesity

(2016) G W Kim et al.   Nutrition & Diabetes

Chemical chaperones reduce ER stress and adipose tissue inflammation in high fat diet-induced mouse model of obesity

(2016) Yaqin Chen et al.   Scientific Reports

Endoplasmic reticulum stress and protein quality control in diabetic cardiomyopathy

(2015) Lifang Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma

(2015) David Y.A. Dadey et al.   Oncotarget

Cudrania tricuspidatawater extract improved obesity-induced hepatic insulin resistance indb/dbmice by suppressing ER stress and inflammation

(2015) Ok-Kyung Kim et al.   Food & Nutrition Research

Nicotine Improves Obesity and Hepatic Steatosis and ER Stress in Diet-Induced Obese Male Rats

(2014) Patricia Seoane-Collazo et al.   ENDOCRINOLOGY

Adiponectin knockout accentuates high fat diet-induced obesity and cardiac dysfunction: Role of autophagy

(2013) Rui Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mechanisms of insulin resistance in obesity

(2013) Jianping Ye   Frontiers of Medicine

Vaspin Is an Adipokine Ameliorating ER Stress in Obesity as a Ligand for Cell-Surface GRP78/MTJ-1 Complex

(2012) A. Nakatsuka et al.   DIABETES

Autophagy

(2010) Lijun Zhou et al.   Autophagy

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Endoplasmic reticulum chaperon tauroursodeoxycholic acid alleviates obesity-induced myocardial contractile dysfunction

(2010) Asli F. Ceylan-Isik et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Chromium Alleviates Glucose Intolerance, Insulin Resistance, and Hepatic ER Stress in Obese Mice

(2008) Nair Sreejayan et al.   Obesity