SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition

Combination of a Histone Deacetylase 6 Inhibitor and a Somatostatin Receptor Agonist Synergistically Reduces Hepatorenal Cystogenesis in an Animal Model of Polycystic Liver Disease

(2018) Maria Lorenzo Pisarello et al.   AMERICAN JOURNAL OF PATHOLOGY

New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases

(2018) Sanda Win et al.   HEPATOLOGY

Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3

(2018) Shoubo Chen et al.   Journal of Neuroinflammation

Sphingosine kinase 2 cooperating with Fyn promotes kidney fibroblast activation and fibrosis via STAT3 and AKT

(2018) Xingxing Zhu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Fibrin(ogen) drives repair after acetaminophen-induced liver injury via leukocyte α M β 2 integrin-dependent upregulation of Mmp12

(2017) Anna K. Kopec et al.   JOURNAL OF HEPATOLOGY

Targeting hepatic macrophages to treat liver diseases

(2017) Frank Tacke   JOURNAL OF HEPATOLOGY

Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage

(2017) Hans Vienken et al.   Scientific Reports

Attenuation of diet-induced obesity and induction of white fat browning with a chemical inhibitor of histone deacetylases

(2016) A Ferrari et al.   INTERNATIONAL JOURNAL OF OBESITY

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Activation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice

(2015) Su-Yeon Lee et al.   HEPATOLOGY

JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death

(2014) S Win et al.   Cell Death & Disease

Sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis is involved in liver fibrosis-associated angiogenesis

(2013) Le Yang et al.   JOURNAL OF HEPATOLOGY

CHOP is a critical regulator of acetaminophen-induced hepatotoxicity

(2013) Dotan Uzi et al.   JOURNAL OF HEPATOLOGY

Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria

(2013) Derick Han et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Inhibition of sphingosine kinase 1 suppresses proliferation of glioma cells under hypoxia by attenuating activity of extracellular signal-regulated kinase

(2012) H. Zhang et al.   CELL PROLIFERATION

A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches

(2012) Ekihiro Seki et al.   GASTROENTEROLOGY

The contribution of endoplasmic reticulum stress to liver diseases

(2011) Lily Dara et al.   HEPATOLOGY

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

Acetaminophen: Old drug, new warnings

(2010) A. SCHILLING et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Endoplasmic reticulum stress in liver disease

(2010) Harmeet Malhi et al.   JOURNAL OF HEPATOLOGY

Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice

(2010) Clarence David Williams et al.   LIVER INTERNATIONAL

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α

(2009) Fernanda Lisbona et al.   MOLECULAR CELL

Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Acetaminophen-Induced Liver Injury by Inhibiting c-Jun N-Terminal Kinase Activation

(2008) Hayato Nakagawa et al.   GASTROENTEROLOGY

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

(2008) Naoko Hanawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE