- Home
- Publications
- Publication Search
- Publication Details
Title
RORγt protein modifications and IL-17-mediated inflammation
Authors
Keywords
IL-17, Th17, RORγt, post-translational modifications, autoimmune diseases
Journal
TRENDS IN IMMUNOLOGY
Volume 42, Issue 11, Pages 1037-1050
Publisher
Elsevier BV
Online
2021-10-12
DOI
10.1016/j.it.2021.09.005
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation
- (2021) Bing Wu et al. IMMUNITY
- Tumor exosome promotes Th17 cell differentiation by transmitting the lncRNA CRNDE-h in colorectal cancer
- (2021) Junfeng Sun et al. Cell Death & Disease
- Cutting Edge: Hypoxia-Induced Ubc9 Promoter Hypermethylation Regulates IL-17 Expression in Ulcerative Colitis
- (2021) Ritesh Kumar et al. JOURNAL OF IMMUNOLOGY
- Metabolic modeling of single Th17 cells reveals regulators of autoimmunity
- (2021) Allon Wagner et al. CELL
- JQ1, a bromodomain inhibitor, suppresses Th17 effectors by blocking p300‐mediated acetylation of RORγt
- (2020) Xiunan Wang et al. BRITISH JOURNAL OF PHARMACOLOGY
- Sumoylation on its 25th anniversary: mechanisms, pathology, and emerging concepts
- (2020) Arda B. Celen et al. FEBS Journal
- Transcriptional Regulators of T Helper 17 Cell Differentiation in Health and Autoimmune Diseases
- (2020) Alessia Capone et al. Frontiers in Immunology
- Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy
- (2020) Lin Wu et al. CELL
- The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24
- (2020) Wai Po Chong et al. IMMUNITY
- Crohn’s disease exacerbated by IL-17 inhibitors in patients with psoriasis: a case report
- (2020) Jingyi Ju et al. BMC GASTROENTEROLOGY
- The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation
- (2020) Dehui Chang et al. IMMUNITY
- Mutation in ITCH Gene Can Cause Syndromic Multisystem Autoimmune Disease With Acute Liver Failure
- (2019) Nicola Kleine-Eggebrecht et al. PEDIATRICS
- Bob1 enhances RORγt-mediated IL-17A expression in Th17 cells through interaction with RORγt
- (2019) Ippei Ikegami et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The IL-17 Family of Cytokines in Health and Disease
- (2019) Mandy J. McGeachy et al. IMMUNITY
- The pathogenicity of Th17 cells in autoimmune diseases
- (2019) Keiko Yasuda et al. Seminars in Immunopathology
- The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells
- (2019) Sara Omenetti et al. IMMUNITY
- Retinoic acid receptor-related orphan receptor gamma-t (RORγt) inhibitors in clinical development for the treatment of autoimmune diseases: a patent review (2016-present)
- (2019) Nannan Sun et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- AhR–ROR-γt complex is a therapeutic target for MAP4K3/GLKhighIL-17Ahigh subpopulation of systemic lupus erythematosus
- (2019) Huai-Chia Chuang et al. FASEB JOURNAL
- NFAT primes the human RORC locus for RORγt expression in CD4+ T cells
- (2019) Hanane Yahia-Cherbal et al. Nature Communications
- Structural mechanisms of HECT-type ubiquitin ligases
- (2018) Sonja Lorenz BIOLOGICAL CHEMISTRY
- Functional Regulation of PPARs through Post-Translational Modifications
- (2018) Reinhard Brunmeir et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease
- (2018) Huai-Chia Chuang et al. Science Advances
- SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2
- (2018) Amir Kumar Singh et al. Nature Communications
- Sumoylation of RORγt regulates TH17 differentiation and thymocyte development
- (2018) Zhiheng He et al. Nature Communications
- Regulation of Th17 Differentiation by IKKα-Dependent and -Independent Phosphorylation of RORγt
- (2017) Zhiheng He et al. JOURNAL OF IMMUNOLOGY
- Phosphorylated Nuclear Receptor CAR Forms a Homodimer To Repress Its Constitutive Activity for Ligand Activation
- (2017) Ryota Shizu et al. MOLECULAR AND CELLULAR BIOLOGY
- SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate RORγt activity in a PKC-θ–dependent manner
- (2017) Subha Sen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sirtuin-1 Activation Controls Tumor Growth by Impeding Th17 Differentiation via STAT3 Deacetylation
- (2017) Emeric Limagne et al. Cell Reports
- SUMOylation pathway alteration coupled with downregulation of SUMO E2 enzyme at mucosal epithelium modulates inflammation in inflammatory bowel disease
- (2017) Salman Ahmad Mustfa et al. Open Biology
- Ndfip1 restricts Th17 cell potency by limiting lineage stability and proinflammatory cytokine production
- (2017) Awo Akosua Kesewa Layman et al. Scientific Reports
- Post-translational regulation of RORγt—A therapeutic target for the modulation of interleukin-17-mediated responses in autoimmune diseases
- (2016) Sascha Rutz et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Ubiquitination of RORγt at Lysine 446 Limits Th17 Differentiation by Controlling Coactivator Recruitment
- (2016) Zhiheng He et al. JOURNAL OF IMMUNOLOGY
- Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR-γt ubiquitination
- (2016) Mahesh Kathania et al. NATURE IMMUNOLOGY
- Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis
- (2016) Xiaohua Xue et al. Scientific Reports
- CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity
- (2015) Chao Wang et al. CELL
- Identification of Natural RORγ Ligands that Regulate the Development of Lymphoid Cells
- (2015) Fabio R. Santori et al. Cell Metabolism
- Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions
- (2015) Dhavalkumar D. Patel et al. IMMUNITY
- Multifaceted role of the ubiquitin ligase Itch in immune regulation
- (2015) K Venuprasad et al. IMMUNOLOGY AND CELL BIOLOGY
- TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression
- (2015) Xiuwen Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SIRT1 deacetylates RORγt and enhances Th17 cell generation
- (2015) Hyung W. Lim et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Ndfip1 Regulates Itch Ligase Activity and Airway Inflammation via UbcH7
- (2015) Mahesh Kathania et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Ubiquitin-Specific Protease 4 Promotes Th17 Cell Function under Inflammation by Deubiquitinating and Stabilizing RORγt
- (2015) Jing Yang et al. JOURNAL OF IMMUNOLOGY
- Sterol metabolism controls T H 17 differentiation by generating endogenous RORγ agonists
- (2015) Xiao Hu et al. Nature Chemical Biology
- Reciprocal regulation of RORγt acetylation and function by p300 and HDAC1
- (2015) Qingsi Wu et al. Scientific Reports
- Acetylation-defective mutants of Pparγ are associated with decreased lipid synthesis in breast cancer cells
- (2015) Lifeng Tian et al. Oncotarget
- Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms
- (2014) Sheng Xiao et al. IMMUNITY
- The E3 Deubiquitinase USP17 Is a Positive Regulator of Retinoic Acid-related Orphan Nuclear Receptor γt (RORγt) in Th17 Cells
- (2014) Lei Han et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells
- (2014) Sascha Rutz et al. NATURE
- The growing landscape of lysine acetylation links metabolism and cell signalling
- (2014) Chunaram Choudhary et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Oxysterols are agonist ligands of ROR t and drive Th17 cell differentiation
- (2014) P. Soroosh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Small molecule inhibitors of RORγt: Targeting Th17 cells and other applications
- (2012) Jun R. Huh et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- A novel isoform of the orphan receptor RORγt suppresses IL-17 production in human T cells
- (2012) T Rauen et al. GENES AND IMMUNITY
- Transcription of Il17 and Il17f Is Controlled by Conserved Noncoding Sequence 2
- (2012) Xiaohu Wang et al. IMMUNITY
- The E3 Ubiquitin Ligase Adaptor Ndfip1 Regulates Th17 Differentiation by Limiting the Production of Proinflammatory Cytokines
- (2012) H. E. Ramon et al. JOURNAL OF IMMUNOLOGY
- Induction and molecular signature of pathogenic TH17 cells
- (2012) Youjin Lee et al. NATURE IMMUNOLOGY
- Function and regulation of SUMO proteases
- (2012) Christopher M. Hickey et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
- (2011) Eric V. Dang et al. CELL
- The Th17 immune response is controlled by the Rel–RORγ–RORγT transcriptional axis
- (2011) Qingguo Ruan et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity
- (2011) Jun R. Huh et al. NATURE
- The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells
- (2011) Huai-Chia Chuang et al. NATURE IMMUNOLOGY
- Human ITCH E3 Ubiquitin Ligase Deficiency Causes Syndromic Multisystem Autoimmune Disease
- (2010) Naomi J. Lohr et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Cbl-b and Itch: Key Regulators of Peripheral T-cell Tolerance
- (2010) K. Venuprasad CANCER RESEARCH
- PER2 Controls Lipid Metabolism by Direct Regulation of PPARγ
- (2010) Benedetto Grimaldi et al. Cell Metabolism
- What are nuclear receptor ligands?
- (2010) Frances M. Sladek MOLECULAR AND CELLULAR ENDOCRINOLOGY
- IκBζ regulates TH17 development by cooperating with ROR nuclear receptors
- (2010) Kazuo Okamoto et al. NATURE
- Generation of pathogenic TH17 cells in the absence of TGF-β signalling
- (2010) Kamran Ghoreschi et al. NATURE
- Ubiquitin chain cleavage: CYLD at work
- (2010) Ramin Massoumi TRENDS IN BIOCHEMICAL SCIENCES
- Physiological functions of the HECT family of ubiquitin ligases
- (2009) Daniela Rotin et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ
- (2008) Xuexian O. Yang et al. IMMUNITY
- Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells
- (2008) Fuping Zhang et al. NATURE IMMUNOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started