Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 21, Pages 2762-2764Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc49771b
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Funding
- Chinese Ministry of Science and Technology [2012ZX09506001-010]
- National Natural Science Foundation of China [21272134, 21172129]
- National Youth Science Foundation [21305074]
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A novel multi-layer microfluidic device was developed for characterization of drug metabolism in human liver microsomes (HLMs) and their cytotoxicity on cells. The results demonstrated that this platform is robust for low levels of compounds and shows potential for high-throughput drug screening in drug development.
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