Time series modeling of live-cell shape dynamics for image-based phenotypic profiling

A generic methodological framework for studying single cell motility in high-throughput time-lapse data

(2015) Alice Schoenauer Sebag et al.   BIOINFORMATICS

Organizational metrics of interchromatin speckle factor domains: integrative classifier for stem cell adhesion & lineage signaling

(2015) Sebastián L. Vega et al.   Integrative Biology

Myosin light chain kinase regulates cell polarization independently of membrane tension or Rho kinase

(2015) Sunny S. Lou et al.   JOURNAL OF CELL BIOLOGY

Open source software for quantification of cell migration, protrusions, and fluorescence intensities

(2015) David J. Barry et al.   JOURNAL OF CELL BIOLOGY

Linking morphodynamics and directional persistence of T lymphocyte migration

(2015) X. Liu et al.   Journal of the Royal Society Interface

Cell shape and the microenvironment regulate nuclear translocation of NF- B in breast epithelial and tumor cells

(2015) J. E. Sero et al.   Molecular Systems Biology

Myosin II controls cellular branching morphogenesis and migration in three dimensions by minimizing cell-surface curvature

(2015) Hunter Elliott et al.   NATURE CELL BIOLOGY

Inferring transient particle transport dynamics in live cells

(2015) Nilah Monnier et al.   NATURE METHODS

How cells explore shape space: A quantitative statistical perspective of cellular morphogenesis

(2014) Zheng Yin et al.   BIOESSAYS

Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet

(2014) James E Bear et al.   CURRENT OPINION IN CELL BIOLOGY

Ligand density elicits a phenotypic switch in human neutrophils

(2014) Steven J. Henry et al.   Integrative Biology

CellGeo: A computational platform for the analysis of shape changes in cells with complex geometries

(2014) Denis Tsygankov et al.   JOURNAL OF CELL BIOLOGY

Plasticity in the Macromolecular-Scale Causal Networks of Cell Migration

(2014) John G. Lock et al.   PLoS One

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling

(2014) M. J. Wawer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-talk between Rho and Rac GTPases drives deterministic exploration of cellular shape space and morphological heterogeneity

(2014) H. Sailem et al.   Open Biology

Advances in Analysis of Low Signal-to-Noise Images Link Dynamin and AP2 to the Functions of an Endocytic Checkpoint

(2013) François Aguet et al.   DEVELOPMENTAL CELL

Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle

(2013) Ran Kafri et al.   NATURE

A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes

(2013) Zheng Yin et al.   NATURE CELL BIOLOGY

Genome-wide single-cell-level screen for protein abundance and localization changes in response to DNA damage in S. cerevisiae

(2013) Aprotim Mazumder et al.   NUCLEIC ACIDS RESEARCH

Machine Learning Prediction of Cancer Cell Sensitivity to Drugs Based on Genomic and Chemical Properties

(2013) Michael P. Menden et al.   PLoS One

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Profiles of Basal and Stimulated Receptor Signaling Networks Predict Drug Response in Breast Cancer Lines

(2013) M. Niepel et al.   Science Signaling

From Cellular Characteristics to Disease Diagnosis: Uncovering Phenotypes with Supercells

(2013) Julián Candia et al.   PLoS Computational Biology

Network Crosstalk Dynamically Changes during Neutrophil Polarization

(2012) Chin-Jen Ku et al.   CELL

Systematic identification of genomic markers of drug sensitivity in cancer cells

(2012) Mathew J. Garnett et al.   NATURE

Unsupervised modeling of cell morphology dynamics for time-lapse microscopy

(2012) Qing Zhong et al.   NATURE METHODS

Immunolabeling artifacts and the need for live-cell imaging

(2012) Ulrike Schnell et al.   NATURE METHODS

Cell Shape Dynamics: From Waves to Migration

(2012) Meghan K. Driscoll et al.   PLoS Computational Biology

Correlation of cell membrane dynamics and cell motility

(2011) Merlin Veronika et al.   BMC BIOINFORMATICS

Development of an optimized backbone of FRET biosensors for kinases and GTPases

(2011) Naoki Komatsu et al.   MOLECULAR BIOLOGY OF THE CELL

Imaging the coordination of multiple signalling activities in living cells

(2011) Christopher M. Welch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Directional Persistence of Cell Migration Coincides with Stability of Asymmetric Intracellular Signaling

(2010) Michael C. Weiger et al.   BIOPHYSICAL JOURNAL

m-calpain Activation Is Regulated by Its Membrane Localization and by Its Binding to Phosphatidylinositol 4,5-Bisphosphate

(2010) Ludovic Leloup et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clustering phenotype populations by genome-wide RNAi and multiparametric imaging

(2010) Florian Fuchs et al.   Molecular Systems Biology

CellCognition: time-resolved phenotype annotation in high-throughput live cell imaging

(2010) Michael Held et al.   NATURE METHODS

Quimp3, an automated pseudopod-tracking algorithm

(2010) Leonard Bosgraaf et al.   Cell Adhesion & Migration

Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts

(2009) M. C. Weiger et al.   JOURNAL OF CELL SCIENCE

Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning

(2009) Thouis R. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoskeleton-based forecasting of stem cell lineage fates

(2009) M. D. Treiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Segregation and activation of myosin IIB creates a rear in migrating cells

(2008) Miguel Vicente-Manzanares et al.   JOURNAL OF CELL BIOLOGY

Mechanism of shape determination in motile cells

(2008) Kinneret Keren et al.   NATURE

Characterizing heterogeneous cellular responses to perturbations

(2008) M. D. Slack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantification of Local Morphodynamics and Local GTPase Activity by Edge Evolution Tracking

(2008) Yuki Tsukada et al.   PLoS Computational Biology