Mechanism of praziquantel action at a parasitic flatworm ion channel

Genetic analysis of praziquantel response in schistosome parasites implicates a transient receptor potential channel

(2021) Winka Le Clec’h et al.   Science Translational Medicine

Antiparasitics in Animal Health: Quo Vadis?

(2020) Paul M. Selzer et al.   TRENDS IN PARASITOLOGY

Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel

(2019) Ying Yin et al.   SCIENCE

Structural insights into TRPM8 inhibition and desensitization

(2019) Melinda M. Diver et al.   SCIENCE

Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel

(2019) Yihe Huang et al.   eLife

The anthelmintic drug praziquantel activates a schistosome transient receptor potential channel

(2019) Sang-Kyu Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Journey to Discovering a Flatworm Target of Praziquantel: A Long TRP

(2019) Sang-Kyu Park et al.   TRENDS IN PARASITOLOGY

Schistosomiasis — Assessing Progress toward the 2020 and 2025 Global Goals

(2019) Arminder K. Deol et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activation of host transient receptor potential (TRP) channels by praziquantel stereoisomers

(2018) Gihan S. Gunaratne et al.   PLoS Neglected Tropical Diseases

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation

(2018) Zhe Zhang et al.   eLife

Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium

(2018) Yihe Huang et al.   NATURE

TRP channels as potential targets for antischistosomals

(2018) Swarna Bais et al.   International Journal for Parasitology-Drugs and Drug Resistance

The Mechanism of Action of Praziquantel: Six Hypotheses

(2018) Charlotte M. Thomas et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Structures and gating mechanism of human TRPM2

(2018) Longfei Wang et al.   SCIENCE

A Persistent Hotspot of Schistosoma mansoni Infection in a Five-Year Randomized Trial of Praziquantel Preventative Chemotherapy Strategies

(2017) Ryan E Wiegand et al.   JOURNAL OF INFECTIOUS DISEASES

ADP-Ribose Activates the TRPM2 Channel from the Sea Anemone Nematostella vectensis Independently of the NUDT9H Domain

(2016) Frank J. P. Kühn et al.   PLoS One

Activity of Praziquantel Enantiomers and Main Metabolites against Schistosoma mansoni

(2014) Isabel Meister et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Human schistosomiasis

(2014) Daniel G Colley et al.   LANCET

Schistosoma mansoni: a method for inducing resistance to praziquantel using infected Biomphalaria glabrata snails

(2014) Flávia FB Couto et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

(2013) G. Madhavi Sastry et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Ca2+ channels and praziquantel: A view from the free world

(2012) John D. Chan et al.   PARASITOLOGY INTERNATIONAL

The Outcome of the Oxidations of Unusual Enediamide Motifs Is Governed by the Stabilities of the Intermediate Iminium Ions

(2012) Muneer Ahamed et al.   PLoS One

Synthesis of new praziquantel analogues: Potential candidates for the treatment of schistosomiasis

(2011) Partha Sarathi Sadhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Combining Global and Local Measures for Structure-Based Druggability Predictions

(2011) Andrea Volkamer et al.   Journal of Chemical Information and Modeling

TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat

(2011) Joris Vriens et al.   NEURON

Praziquantel analogs with activity against juvenile Schistosoma mansoni

(2010) Yuxiang Dong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identifying and Characterizing Binding Sites and Assessing Druggability

(2009) Thomas A. Halgren   Journal of Chemical Information and Modeling