Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation

Structural insights into emergent signaling modes of G protein–coupled receptors

(2020) Ieva Sutkeviciute et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric interactions in the parathyroid hormone GPCR–arrestin complex formation

(2020) Lisa J. Clark et al.   Nature Chemical Biology

Optical Mapping of cAMP Signaling at the Nanometer Scale

(2020) Andreas Bock et al.   CELL

Ca2+ allostery in PTH-receptor signaling

(2019) Alex D. White et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTH/PTHrP Receptor Signaling, Allostery, and Structures

(2019) Ieva Sutkeviciute et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Revealing the architecture of protein complexes by an orthogonal approach combining HDXMS, CXMS, and disulfide trapping

(2018) Kunhong Xiao et al.   Nature Protocols

Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling

(2018) Dean P. Staus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purinergic Receptor Transactivation by the β 2 -Adrenergic Receptor Increases Intracellular Ca 2+ in Nonexcitable Cells

(2017) Wayne Stallaert et al.   MOLECULAR PHARMACOLOGY

Functional selectivity of GPCR-directed drug action through location bias

(2017) Roshanak Irannejad et al.   Nature Chemical Biology

Actin-Sorting Nexin 27 (SNX27)-Retromer Complex Mediates Rapid Parathyroid Hormone Receptor Recycling

(2016) Jennifer C. McGarvey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacodynamic Actions of a Long-Acting PTH Analog (LA-PTH) in Thyroparathyroidectomized (TPTX) Rats and Normal Monkeys

(2016) Masaru Shimizu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

β2-adrenergic receptor control of endosomal PTH receptor signaling via Gβγ

(2016) Frédéric G Jean-Alphonse et al.   Nature Chemical Biology

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

(2016) Jing Huang et al.   NATURE METHODS

CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field

(2015) Jumin Lee et al.   Journal of Chemical Theory and Computation

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

Evol and ProDy for bridging protein sequence evolution and structural dynamics

(2014) A. Bakan et al.   BIOINFORMATICS

CHARMM-GUIMembrane Buildertoward realistic biological membrane simulations

(2014) Emilia L. Wu et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase

(2014) Alexandre Gidon et al.   Nature Chemical Biology

Endosomal generation of cAMP in GPCR signaling

(2014) Jean-Pierre Vilardaga et al.   Nature Chemical Biology

Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry

(2014) Alem W Kahsai et al.   Nature Protocols

Glucagon-like peptide-1 receptor-mediated endosomal cAMP generation promotes glucose-stimulated insulin secretion in pancreatic β-cells

(2013) Ramya S. Kuna et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adrenergic Nervous System in Heart Failure

(2013) Anastasios Lymperopoulos et al.   CIRCULATION RESEARCH

Noncanonical Control of Vasopressin Receptor Type 2 Signaling by Retromer and Arrestin

(2013) Timothy N. Feinstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tracking circadian rhythms of bone mineral deposition in murine calvarial organ cultures

(2013) John-David P McElderry et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

(2013) D. Wootten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noncanonical GPCR signaling arising from a PTH receptor–arrestin–Gβγ complex

(2013) Vanessa L. Wehbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ezrin-anchored Protein Kinase A Coordinates Phosphorylation-dependent Disassembly of a NHERF1 Ternary Complex to Regulate Hormone-sensitive Phosphate Transport

(2012) Bin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP

(2012) Vedangi Sample et al.   Nature Chemical Biology

Non-canonical signaling of the PTH receptor

(2012) Jean-Pierre Vilardaga et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

ProDy: Protein Dynamics Inferred from Theory and Experiments

(2011) A. Bakan et al.   BIOINFORMATICS

β2-Adrenergic Receptor Lysosomal Trafficking Is Regulated by Ubiquitination of Lysyl Residues in Two Distinct Receptor Domains

(2011) Kunhong Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retromer terminates the generation of cAMP by internalized PTH receptors

(2011) Timothy N Feinstein et al.   Nature Chemical Biology

OPM database and PPM web server: resources for positioning of proteins in membranes

(2011) Mikhail A. Lomize et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation Barcoding as a Mechanism of Directing GPCR Signaling

(2011) S. B. Liggett   Science Signaling

Distinct Phosphorylation Sites on the  2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of  -Arrestin

(2011) K. N. Nobles et al.   Science Signaling

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Normal Mode Analysis of Biomolecular Structures: Functional Mechanisms of Membrane Proteins

(2009) Ivet Bahar et al.   CHEMICAL REVIEWS

Sustained cyclic AMP production by parathyroid hormone receptor endocytosis

(2009) Sébastien Ferrandon et al.   Nature Chemical Biology

Persistent cAMP-Signals Triggered by Internalized G-Protein–Coupled Receptors

(2009) Davide Calebiro et al.   PLOS BIOLOGY

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS

The Impact of Peptide Abundance and Dynamic Range on Stable-Isotope-Based Quantitative Proteomic Analyses

(2008) Corey E. Bakalarski et al.   JOURNAL OF PROTEOME RESEARCH

Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption

(2008) Michelle Boone et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation

(2008) M. Okazaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered Selectivity of Parathyroid Hormone (PTH) and PTH-Related Protein (PTHrP) for Distinct Conformations of the PTH/PTHrP Receptor

(2007) Thomas Dean et al.   MOLECULAR ENDOCRINOLOGY