DNA-PK promotes activation of the survival kinase AKT in response to DNA damage through an mTORC2-ECT2 pathway

Akt-targeted therapy as a promising strategy to overcome drug resistance in breast cancer – A comprehensive review from chemotherapy to immunotherapy

(2020) Parham Jabbarzadeh Kaboli et al.   PHARMACOLOGICAL RESEARCH

Regulation of mTORC2 Signaling

(2020) Wenxiang Fu et al.   Genes

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2

(2019) Joanna R. Kovalski et al.   MOLECULAR CELL

Phosphorylated Rho–GDP directly activates mTORC2 kinase towards AKT through dimerization with Ras–GTP to regulate cell migration

(2019) Hiroshi Senoo et al.   NATURE CELL BIOLOGY

MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression

(2019) Yao Jiang et al.   Nature Communications

Highlights in Resistance Mechanism Pathways for Combination Therapy

(2019) Delou et al.   Cells

CUL5-SOCS6 complex regulates mTORC2 function by targeting Sin1 for degradation

(2019) Binghai Cui et al.   Cell Discovery

mTOR as a central hub of nutrient signalling and cell growth

(2018) Joungmok Kim et al.   NATURE CELL BIOLOGY

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

mTORC1 and -2 Coordinate Transcriptional and Translational Reprogramming in Resistance to DNA Damage and Replicative Stress in Breast Cancer Cells

(2016) Deborah Silvera et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt

(2016) Jinfang Zhang et al.   MOLECULAR CELL

Akt-Mediated Phosphorylation of XLF Impairs Non-Homologous End-Joining DNA Repair

(2015) Pengda Liu et al.   MOLECULAR CELL

The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis

(2015) Nicholas Jette et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex

(2015) P. Liu et al.   Cancer Discovery

DNA-PK Mediates AKT Activation and Apoptosis Inhibition in Clinically Acquired Platinum Resistance

(2015) Euan A. Stronach et al.   NEOPLASIA

Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4

(2014) Yang Zou et al.   FEBS LETTERS

Role of AKT signaling in DNA repair and clinical response to cancer therapy

(2014) Q. Liu et al.   NEURO-ONCOLOGY

mTORC2 Is Required for Rit-Mediated Oxidative Stress Resistance

(2014) Weikang Cai et al.   PLoS One

Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2

(2013) Sean J. Humphrey et al.   Cell Metabolism

DNA-Damaging Agents in Cancer Chemotherapy: Serendipity and Chemical Biology

(2013) Kahlin Cheung-Ong et al.   CHEMISTRY & BIOLOGY

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

(2013) Pengda Liu et al.   NATURE CELL BIOLOGY

Cancer and Radiation Therapy: Current Advances and Future Directions

(2012) Rajamanickam Baskar et al.   International Journal of Medical Sciences

PI3K-PKB/Akt Pathway

(2012) B. A. Hemmings et al.   Cold Spring Harbor Perspectives in Biology

Akt: A Double-Edged Sword in Cell Proliferation and Genome Stability

(2012) Naihan Xu et al.   Journal of Oncology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks

(2011) Michael Fraser et al.   CELL CYCLE

mTOR complex 2 signaling and functions

(2011) Won Jun Oh et al.   CELL CYCLE

Akt signalling in health and disease

(2011) Ingeborg Hers et al.   CELLULAR SIGNALLING

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size

(2011) Abdelhafid Saci et al.   MOLECULAR CELL

APCcdh1 Mediates Degradation of the Oncogenic Rho-GEF Ect2 after Mitosis

(2011) Caroline Liot et al.   PLoS One

Exploring the Gain of Function Contribution of AKT to Mammary Tumorigenesis in Mouse Models

(2010) Carmen Blanco-Aparicio et al.   PLoS One

14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response

(2009) Duaa H. Mohammad et al.   DNA REPAIR

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

AKT1 Inhibits Homologous Recombination by Inducing Cytoplasmic Retention of BRCA1 and RAD51

(2008) I. Plo et al.   CANCER RESEARCH

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

(2008) Tsuneo Ikenoue et al.   EMBO JOURNAL

PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival

(2008) Lana Bozulic et al.   MOLECULAR CELL

AKT Is Activated in an Ataxia-Telangiectasia and Rad3-Related-Dependent Manner in Response to Temozolomide and Confers Protection against Drug-Induced Cell Growth Inhibition

(2008) S. Caporali et al.   MOLECULAR PHARMACOLOGY

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

(2008) Beth Apsel et al.   Nature Chemical Biology

p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK

(2008) K. A. Boehme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE