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Physical Principles Underlying the Complex Biology of Intracellular Phase Transitions

(2020) Jeong-Mo Choi et al.   Annual Review of Biophysics

Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization

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RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

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Splicing at the phase-separated nuclear speckle interface: a model

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Nuclear mechanisms of gene expression control: pre-mRNA splicing as a life or death decision

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(2019) Stephanie L. Moon et al.   NATURE CELL BIOLOGY

Stoichiometry controls activity of phase-separated clusters of actin signaling proteins

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Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Structure and function of eTudor domain containing TDRD proteins

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Functional characterization of SMN evolution in mouse models of SMA

(2019) Erkan Y. Osman et al.   Scientific Reports

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

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Organization of Chromatin by Intrinsic and Regulated Phase Separation

(2019) Bryan A. Gibson et al.   CELL

Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences

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The liquid nucleome – phase transitions in the nucleus at a glance

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Phase Transitions in the Assembly and Function of Human miRISC

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Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation

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A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

(2018) Jie Wang et al.   CELL

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

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Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation

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RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome

(2018) Briana Van Treeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mRNA structure determines specificity of a polyQ-driven phase separation

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Mediator and RNA polymerase II clusters associate in transcription-dependent condensates

(2018) Won-Ki Cho et al.   SCIENCE

A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy

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Intrinsically Disordered Regions Can Contribute Promiscuous Interactions to RNP Granule Assembly

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Who's In and Who's Out—Compositional Control of Biomolecular Condensates

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Biomolecular condensates: organizers of cellular biochemistry

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Compositional Control of Phase-Separated Cellular Bodies

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Arginine Demethylation of G3BP1 Promotes Stress Granule Assembly

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Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein

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SMN - A chaperone for nuclear RNP social occasions?

(2016) Amanda C. Raimer et al.   RNA Biology

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases

(2015) Mohammad S. Eram et al.   ACS Chemical Biology

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

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A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

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Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

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Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

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SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination

(2015) Dorothy Yanling Zhao et al.   NATURE

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

(2015) Elayne Chan-Penebre et al.   Nature Chemical Biology

Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck

(2015) Sudeep Banjade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics

(2015) Shana Elbaum-Garfinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SART3-Dependent Accumulation of Incomplete Spliceosomal snRNPs in Cajal Bodies

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Liquid-Liquid Phase Separation in Biology

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Arginine Methylation Facilitates the Recruitment of TOP3B to Chromatin to Prevent R Loop Accumulation

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(2013) Lukasz J Bugaj et al.   NATURE METHODS

Tudor: a versatile family of histone methylation ‘readers’

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Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

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Reorganization of Cajal bodies and nucleolar targeting of coilin in motor neurons of type I spinal muscular atrophy

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Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

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(2012) Johannes Schindelin et al.   NATURE METHODS

Template-based protein structure modeling using the RaptorX web server

(2012) Morten Källberg et al.   Nature Protocols

Crystal Structure of TDRD3 and Methyl-Arginine Binding Characterization of TDRD3, SMN and SPF30

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Structure of a Key Intermediate of the SMN Complex Reveals Gemin2's Crucial Function in snRNP Assembly

(2011) Rundong Zhang et al.   CELL

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

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Deciphering arginine methylation: Tudor tells the tale

(2011) Chen Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins

(2011) Konstantinos Tripsianes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes

(2011) C. P. Brangwynne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for methylarginine-dependent recognition of Aubergine by Tudor

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TDRD3 Is an Effector Molecule for Arginine-Methylated Histone Marks

(2010) Yanzhong Yang et al.   MOLECULAR CELL

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Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis

(2010) Magdalena Strzelecka et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The spinal muscular atrophy protein SMN affects Drosophila germline nuclear organization through the U body–P body pathway

(2009) Lin Lee et al.   DEVELOPMENTAL BIOLOGY

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules

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Spherical nanosized focal spot unravels the interior of cells

(2008) Roman Schmidt et al.   NATURE METHODS