Combining in vitro assays and mathematical modelling to study developmental neurotoxicity induced by chemical mixtures

Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models

(2021) Susana Proença et al.   TOXICOLOGY IN VITRO

The endogenous and exogenous brain-derived neurotrophic factor plays pivotal roles in the pathogenesis of stroke onset in high salt-loaded hypertensive rats

(2021) Yu Hasegawa et al.   EXPERIMENTAL GERONTOLOGY

Acute oral methylmercury exposure perturbs the gut microbiome and alters gut-brain axis related metabolites in rats

(2020) Xiaoying Lin et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Assessment of developmental neurotoxicity induced by chemical mixtures using an adverse outcome pathway concept

(2020) Francesca Pistollato et al.   Environmental Health

Prenatal Ethanol Exposure Leads to Attention Deficits in Both Male and Female Rats

(2020) Ruixiang Wang et al.   Frontiers in Neuroscience

Ginseng Gintonin Attenuates Lead-Induced Rat Cerebellar Impairments during Gestation and Lactation

(2020) Sung Min Nam et al.   Biomolecules

Analysis of lead, arsenic and calcium content in the hair of children with autism spectrum disorder

(2020) Joanna Fiłon et al.   BMC PUBLIC HEALTH

Disruption of synaptic expression pattern and age-related DNA oxidation in a neuronal model of lead-induced toxicity

(2020) Zuntao Wu et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Certain ortho-hydroxylated brominated ethers are promiscuous kinase inhibitors that impair neuronal signaling and neurodevelopmental processes

(2020) Robert G. Poston et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Red Beetroot Extract Abrogates Chlorpyrifos-Induced Cortical Damage in Rats

(2020) Gadah Albasher et al.   Oxidative Medicine and Cellular Longevity

Organophosphate Pesticides Exposure during Fetal Development and IQ Scores in 3 and 4-Year Old Canadian Children

(2020) Patrick Ntantu Nkinsa et al.   ENVIRONMENTAL RESEARCH

Deciphering the star codings: astrocyte manipulation alters mouse behavior

(2020) Keebum Park et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Prenatal bisphenol-A exposure altered exploratory and anxiety-like behaviour and induced non-monotonic, sex-specific changes in the cortical expression of CYP19A1, BDNF and intracellular signaling proteins in F1 rats

(2020) Glancis Luzeena Raja et al.   FOOD AND CHEMICAL TOXICOLOGY

Combination effect of exercise training and eugenol supplementation on the hippocampus apoptosis induced by chlorpyrifos

(2020) Sina Nikbin et al.   MOLECULAR BIOLOGY REPORTS

An analysis of the limitations and uncertainties of in vivo developmental neurotoxicity testing and assessment to identify the potential for alternative approaches

(2020) Martin Paparella et al.   REPRODUCTIVE TOXICOLOGY

Effects of methylmercury on the pattern of NADPH diaphorase expression and astrocytic activation in the rat

(2020) Marco Aurelio M. Freire et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Integrating biokinetics and in vitro studies to evaluate developmental neurotoxicity induced by chlorpyrifos in human iPSC-derived neural stem cells undergoing differentiation towards neuronal and glial cells

(2020) Emma Di Consiglio et al.   REPRODUCTIVE TOXICOLOGY

Exposure to human relevant mixtures of halogenated persistent organic pollutants (POPs) alters neurodevelopmental processes in human neural stem cells undergoing differentiation

(2020) Nichlas Davidsen et al.   REPRODUCTIVE TOXICOLOGY

Very low-level prenatal mercury exposure and behaviors in children: the HOME Study

(2019) Nimesh B. Patel et al.   Environmental Health

Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue

(2019) Jun Nagai et al.   CELL

Neurodegeneration, demyelination, and astrogliosis in rat spinal cord by chronic lead treatment

(2019) Sheila Adela Villa‐Cedillo et al.   CELL BIOLOGY INTERNATIONAL

Memantine Is Protective against Cytotoxicity Caused by Lead and Quinolinic Acid in Cultured Rat Embryonic Hippocampal Cells

(2019) Abdur Rahman et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Extenuation of in utero toxic effects of MeHg in the developing neurons by Fisetin via modulating the expression of synaptic transmission and plasticity regulators in hippocampus of the rat offspring

(2019) Sherin Jacob et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Blood heavy metals and brain-derived neurotrophic factor in the first trimester of pregnancy among migrant workers

(2019) Ye Htet Zaw et al.   PLoS One

Development and analysis of an adverse outcome pathway network for human neurotoxicity

(2019) Nicoleta Spinu et al.   ARCHIVES OF TOXICOLOGY

Correction to: c-Jun Amino-Terminal Kinase is Involved in Valproic Acid-Mediated Neuronal Differentiation of Mouse Embryonic NSCs and Neurite Outgrowth of NSC-Derived Neurons

(2019) Lu Lu et al.   NEUROCHEMICAL RESEARCH

Antineuroinflammatory therapy: potential treatment for autism spectrum disorder by inhibiting glial activation and restoring synaptic function

(2019) Yong-Jiang Li et al.   CNS SPECTRUMS

Developmental exposure to lead at environmentally relevant concentrations impaired neurobehavior and NMDAR-dependent BDNF signaling in zebrafish larvae

(2019) Jing Zhao et al.   ENVIRONMENTAL POLLUTION

Neuroprotective activation of astrocytes by methylmercury exposure in the inferior colliculus

(2019) Yasuhiro Ishihara et al.   Scientific Reports

Increased expression of BDNF mRNA in the frontal cortex of autistic patients

(2018) Gilles Maussion et al.   BEHAVIOURAL BRAIN RESEARCH

Cypermethrin, chlorpyrifos, deltamethrin, and imidacloprid exposure up-regulates the mRNA and protein levels of bdnf and c-fos in the brain of adult zebrafish ( Danio rerio )

(2018) Selçuk Özdemir et al.   CHEMOSPHERE

2,3,7,8-Tetrachlorodibenzo- p -dioxin promotes migration ability of primary cultured rat astrocytes via aryl hydrocarbon receptor

(2018) Yangsheng Chen et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

Chemical Contaminants in Raw and Pasteurized Human Milk

(2018) Jennifer C. Hartle et al.   JOURNAL OF HUMAN LACTATION

The protective effect of α-lipoic acid against bisphenol A-induced neurobehavioral toxicity

(2018) Jasim Khan et al.   NEUROCHEMISTRY INTERNATIONAL

The miR206-JunD Circuit Mediates the Neurotoxic Effect of Methylmercury in Cortical Neurons

(2018) Natascia Guida et al.   TOXICOLOGICAL SCIENCES

Testing for developmental neurotoxicity using a battery of in vitro assays for key cellular events in neurodevelopment

(2018) Joshua A. Harrill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Development of the Adverse Outcome Pathway (AOP): Chronic binding of antagonist to N -methyl- d -aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities of children

(2018) Magdalini Sachana et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Strategies to improve the regulatory assessment of developmental neurotoxicity (DNT) using in vitro methods

(2018) Anna Bal-Price et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Valproic acid promotes the neuronal differentiation of spiral ganglion neural stem cells with robust axonal growth

(2018) Byoung-San Moon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of lead, mercury, aluminium and manganese co-exposure on the serum BDNF concentration of pre-school children in Taizhou, China

(2018) Can-Can Zhou et al.   CHEMOSPHERE

Prenatal naled and chlorpyrifos exposure is associated with deficits in infant motor function in a cohort of Chinese infants

(2017) Monica K. Silver et al.   ENVIRONMENT INTERNATIONAL

Valproate Attenuates Endoplasmic Reticulum Stress-Induced Apoptosis in SH-SY5Y Cells via the AKT/GSK3β Signaling Pathway

(2017) Zhengmao Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Methylmercury exposure for 14 days (short-term) produces behavioral and biochemical changes in mouse cerebellum, liver, and serum

(2017) Sérgio José Macedo-Júnior et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

The Putative Role of Environmental Mercury in the Pathogenesis and Pathophysiology of Autism Spectrum Disorders and Subtypes

(2017) G. Morris et al.   MOLECULAR NEUROBIOLOGY

Evaluation of the rotenone-induced activation of the Nrf2 pathway in a neuronal model derived from human induced pluripotent stem cells

(2017) Dimitra Zagoura et al.   NEUROCHEMISTRY INTERNATIONAL

Adverse outcome pathways: Application to enhance mechanistic understanding of neurotoxicity

(2017) Anna Bal-Price et al.   PHARMACOLOGY & THERAPEUTICS

From the Cover: AstrocytesAre Protective Against Chlorpyrifos Developmental Neurotoxicity in Human Pluripotent Stem Cell-Derived Astrocyte-Neuron Cocultures

(2017) Xian Wu et al.   TOXICOLOGICAL SCIENCES

Meta-Analysis of BDNF Levels in Autism

(2016) Raluca Armeanu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Pesticide exposure and neurodevelopment in children aged 6–9 years from Talamanca, Costa Rica

(2016) Berna van Wendel de Joode et al.   CORTEX

Biomarkers of exposure to environmental contaminants in French pregnant women from the Elfe cohort in 2011

(2016) Clémentine Dereumeaux et al.   ENVIRONMENT INTERNATIONAL

Effects of Perinatal Dioxin Exposure on Development of Children during the First 3 Years of Life

(2016) Pham The Tai et al.   JOURNAL OF PEDIATRICS

Role of astrocyte-synapse interactions in CNS disorders

(2016) Elena Blanco-Suárez et al.   JOURNAL OF PHYSIOLOGY-LONDON

Should the scope of human mixture risk assessment span legislative/regulatory silos for chemicals?

(2016) Richard M. Evans et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Impairment of object recognition memory by maternal bisphenol A exposure is associated with inhibition of Akt and ERK/CREB/BDNF pathway in the male offspring hippocampus

(2016) Chong Wang et al.   TOXICOLOGY

Repeated exposure to neurotoxic levels of chlorpyrifos alters hippocampal expression of neurotrophins and neuropeptides

(2016) Young S. Lee et al.   TOXICOLOGY

Opposing presynaptic roles of BDNF and ProBDNF in the regulation of persistent activity in the entorhinal cortex

(2016) Julien Gibon et al.   Molecular Brain

Serum levels of valproic acid during delivery in mothers and in umbilical cord - correlation with birth length and weight

(2015) Ivana Kacirova et al.   BIOMEDICAL PAPERS-OLOMOUC

Valproic Acid Modifies Synaptic Structure and Accelerates Neurite Outgrowth Via the Glycogen Synthase Kinase-3β Signaling Pathway in an Alzheimer's Disease Model

(2015) Zhi-Min Long et al.   CNS Neuroscience & Therapeutics

Putative adverse outcome pathways relevant to neurotoxicity

(2015) Anna Bal-Price et al.   CRITICAL REVIEWS IN TOXICOLOGY

Common Mechanisms of Excitatory and Inhibitory Imbalance in Schizophrenia and Autism Spectrum Disorders

(2015) R. Gao et al.   CURRENT MOLECULAR MEDICINE

Differential Gene Expression Patterns in Developing Sexually Dimorphic Rat Brain Regions Exposed to Antiandrogenic, Estrogenic, or Complex Endocrine Disruptor Mixtures: Glutamatergic Synapses as Target

(2015) Walter Lichtensteiger et al.   ENDOCRINOLOGY

Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury

(2015) Takuya Takemoto et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Brain derived neurotrophic factor (BDNF) and autism spectrum disorders (ASD) in childhood

(2015) V. Bryn et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Plasticity-related genes in brain development and amygdala-dependent learning

(2015) D. E. Ehrlich et al.   GENES BRAIN AND BEHAVIOR

Urinary biomarker concentrations of captan, chlormequat, chlorpyrifos and cypermethrin in UK adults and children living near agricultural land

(2015) Karen S Galea et al.   Journal of Exposure Science and Environmental Epidemiology

Exposure to Mixtures of Metals and Neurodevelopmental Outcomes: A Multidisciplinary Review Using an Adverse Outcome Pathway Framework

(2015) Katherine von Stackelberg et al.   RISK ANALYSIS

Neonatal chlorpyrifos exposure induces loss of dopaminergic neurons in young adult rats

(2015) Jie Zhang et al.   TOXICOLOGY

Epigenetic effects of low perinatal doses of flame retardant BDE-47 on mitochondrial and nuclear genes in rat offspring

(2015) Hyang-Min Byun et al.   TOXICOLOGY

Lead exposure induced microgliosis and astrogliosis in hippocampus of young mice potentially by triggering TLR4–MyD88–NFκB signaling cascades

(2015) Jin-Tao Liu et al.   TOXICOLOGY LETTERS

Rapid method for the simultaneous determination of DDTs and PCBs in hair of children by headspace solid phase microextraction and gas chromatography-mass spectrometry (HSSPME/GC-MS)

(2014) Manolis N. Tzatzarakis et al.   Drug Testing and Analysis

Prenatal exposure to endocrine disrupting chemicals in relation to thyroid hormone levels in infants – a Dutch prospective cohort study

(2014) Marijke de Cock et al.   Environmental Health

Current concepts in neuroendocrine disruption

(2014) Martha León-Olea et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Attention, locomotor activity and developmental milestones in rats prenatally exposed to ethanol

(2014) Ivani Brys et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Astrocyte-Derived BDNF Supports Myelin Protein Synthesis after Cuprizone-Induced Demyelination

(2014) C. G. Fulmer et al.   JOURNAL OF NEUROSCIENCE

Neurobehavioural effects of developmental toxicity

(2014) Philippe Grandjean et al.   LANCET NEUROLOGY

Selective cognitive deficits in adult rats after prenatal exposure to inhaled ethanol

(2014) W.M. Oshiro et al.   NEUROTOXICOLOGY AND TERATOLOGY

Developmental neurotoxicity and anticonvulsant drugs: A possible link

(2014) A. Verrotti et al.   REPRODUCTIVE TOXICOLOGY

Maternal Bisphenol A Diet Induces Anxiety-Like Behavior in Female Juvenile with Neuroimmune Activation

(2014) Guangying Luo et al.   TOXICOLOGICAL SCIENCES

Oral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats

(2014) Tingting Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Environmental Chemical Exposures and Autism Spectrum Disorders: A Review of the Epidemiological Evidence

(2014) Amy E. Kalkbrenner et al.   Current Problems in Pediatric and Adolescent Health Care

In utero exposure to environmental lead and manganese and neurodevelopment at 2 years of age

(2013) Ching-Chun Lin et al.   ENVIRONMENTAL RESEARCH

Exposure to an organophosphate pesticide, individually or in combination with other Gulf War agents, impairs synaptic integrity and neuronal differentiation, and is accompanied by subtle microvascular injury in a mouse model of Gulf War agent exposure

(2013) Joseph O. Ojo et al.   NEUROPATHOLOGY

In utero exposure to valproic acid and autism — A current review of clinical and animal studies

(2013) Florence I. Roullet et al.   NEUROTOXICOLOGY AND TERATOLOGY

Polychlorinated biphenyls impair dibutyryl cAMP-induced astrocytic differentiation in rat C6 glial cell line

(2013) Annagrazia Adornetto et al.   FEBS Open Bio

In vitroevaluation of gene expression changes for gonadotropin-releasing hormone 1, brain-derived neurotrophic factor and neurotrophic tyrosine kinase, receptor, type 2, in response to bisphenol A treatment

(2012) Katsuhiko Warita et al.   CONGENITAL ANOMALIES

Tipping the Balance of Autism Risk: Potential Mechanisms Linking Pesticides and Autism

(2012) Janie F. Shelton et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

In Utero and Childhood Polybrominated Diphenyl Ether (PBDE) Exposures and Neurodevelopment in the CHAMACOS Study

(2012) Brenda Eskenazi et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Brain anomalies in children exposed prenatally to a common organophosphate pesticide

(2012) V. A. Rauh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulation of BDNF-TrkB Signaling in Developing Hippocampal Neurons by Pb2+: Implications for an Environmental Basis of Neurodevelopmental Disorders

(2012) Kirstie H. Stansfield et al.   TOXICOLOGICAL SCIENCES

High dose bisphenol A impairs hippocampal neurogenesis in female mice across generations

(2012) Young Jung Jang et al.   TOXICOLOGY

Hair Toxic Metal Concentrations and Autism Spectrum Disorder Severity in Young Children

(2012) David Geier et al.   International Journal of Environmental Research and Public Health

Bisphenol-A suppresses neurite extension due to inhibition of phosphorylation of mitogen-activated protein kinase in PC12 cells

(2011) Sayaka Seki et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Neuron Number and Size in Prefrontal Cortex of Children With Autism

(2011) Eric Courchesne et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The effect of consequent exposure of stress and dermal application of low doses of chlorpyrifos on the expression of glial fibrillary acidic protein in the hippocampus of adult mice

(2011) Kian Lim et al.   Journal of Occupational Medicine and Toxicology

Polychlorinated Biphenyls PCB 52, PCB 180, and PCB 138 Impair the Glutamate−Nitric Oxide−cGMP Pathway in Cerebellar Neurons in Culture by Different Mechanisms

(2010) Marta Llansola et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Exposure patterns of UV filters, fragrances, parabens, phthalates, organochlor pesticides, PBDEs, and PCBs in human milk: Correlation of UV filters with use of cosmetics

(2010) Margret Schlumpf et al.   CHEMOSPHERE

Developmental and metabolic brain alterations in rats exposed to bisphenol A during gestation and lactation

(2010) Nicolas Kunz et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Lead Exposure during Synaptogenesis Alters Vesicular Proteins and Impairs Vesicular Release: Potential Role of NMDA Receptor–Dependent BDNF Signaling

(2010) April P. Neal et al.   TOXICOLOGICAL SCIENCES

A glutamatergic component of lead toxicity in adult brain: The role of astrocytic glutamate transporters

(2009) Lidia Strużyńska   NEUROCHEMISTRY INTERNATIONAL

Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro

(2008) Theodore A. Slotkin et al.   BRAIN RESEARCH BULLETIN

BDNF is essential to promote persistence of long-term memory storage

(2008) P. Bekinschtein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bisphenol A Prevents the Synaptogenic Response to Testosterone in the Brain of Adult Male Rats

(2007) Csaba Leranth et al.   ENDOCRINOLOGY