Antineuroinflammatory therapy: potential treatment for autism spectrum disorder by inhibiting glial activation and restoring synaptic function

Maternal Systemic Interleukin-6 During Pregnancy Is Associated With Newborn Amygdala Phenotypes and Subsequent Behavior at 2 Years of Age

(2018) Alice M. Graham et al.   BIOLOGICAL PSYCHIATRY

Pre-eclampsia and the risk of autism-spectrum disorder in offspring: meta-analysis

(2018) Berihun Assefa Dachew et al.   BRITISH JOURNAL OF PSYCHIATRY

Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights

(2018) Diego de Sá Coutinho et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resveratrol: An overview of its anti-cancer mechanisms

(2018) Mohamed Elshaer et al.   LIFE SCIENCES

Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial

(2018) Hidenori Yamasue et al.   MOLECULAR PSYCHIATRY

Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli

(2018) Stephen Bent et al.   Molecular Autism

Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection

(2018) Jan Bakos et al.   NEURAL PLASTICITY

Microglia and Beyond: Innate Immune Cells As Regulators of Brain Development and Behavioral Function

(2018) Kathryn M. Lenz et al.   Frontiers in Immunology

Oxytocin improves animal behaviors and ameliorates oxidative stress and inflammation in autistic mice

(2018) Yu Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Autism spectrum disorder

(2018) Catherine Lord et al.   LANCET

Open-Label Trial of Vitamin D3 Supplementation in Children with Autism Spectrum Disorder

(2017) Stephen Bent et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Modulators of microglial activation and polarization after intracerebral haemorrhage

(2017) Xi Lan et al.   Nature Reviews Neurology

Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders

(2017) Urte Neniskyte et al.   NATURE REVIEWS NEUROSCIENCE

Resveratrol suppresses neuroinflammation in the experimental paradigm of autism spectrum disorders

(2017) Ranjana Bhandari et al.   NEUROCHEMISTRY INTERNATIONAL

Vitamin D and autism, what’s new?

(2017) John Jacob Cannell   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Cytokine levels and associations with symptom severity in male and female children with autism spectrum disorder

(2017) Anne Masi et al.   Molecular Autism

Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses

(2017) Amirhossein Modabbernia et al.   Molecular Autism

Maternal autoimmune diseases and the risk of autism spectrum disorders in offspring: A systematic review and meta-analysis

(2016) Shao-wei Chen et al.   BEHAVIOURAL BRAIN RESEARCH

Oxytocin Treatment, Circuitry, and Autism: A Critical Review of the Literature Placing Oxytocin Into the Autism Context

(2016) Adam J. Guastella et al.   BIOLOGICAL PSYCHIATRY

Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders

(2016) Ki Chan Kim et al.   Biomolecules & Therapeutics

Maternal infection during pregnancy and risk of autism spectrum disorders: A systematic review and meta-analysis

(2016) Hai-yin Jiang et al.   BRAIN BEHAVIOR AND IMMUNITY

Biomarker-Guided Strategy for Treatment of Autism Spectrum Disorder (ASD)

(2016) Hua Liu et al.   CNS & Neurological Disorders-Drug Targets

Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice

(2016) Lin Yuan et al.   Journal of Neuroinflammation

Resveratrol Reverses the Synaptic Plasticity Deficits in a Chronic Cerebral Hypoperfusion Rat Model

(2016) Huagang Li et al.   Journal of Stroke & Cerebrovascular Diseases

Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects

(2016) H-J Kim et al.   MOLECULAR PSYCHIATRY

Clinical improvement following vitamin D3 supplementation in Autism Spectrum Disorder

(2016) Junyan Feng et al.   NUTRITIONAL NEUROSCIENCE

Pharmacologic Treatment of Severe Irritability and Problem Behaviors in Autism: A Systematic Review and Meta-analysis

(2016) L. K. Fung et al.   PEDIATRICS

Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes

(2016) Won-Suk Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternal immune activation: Implications for neuropsychiatric disorders

(2016) M. L. Estes et al.   SCIENCE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Sulforaphane induces neurovascular protection against a systemic inflammatory challenge via both Nrf2-dependent and independent pathways

(2016) Paul M. Holloway et al.   VASCULAR PHARMACOLOGY

Astrocytes and Microglia and Their Potential Link with Autism Spectrum Disorders

(2016) Francesco Petrelli et al.   Frontiers in Cellular Neuroscience

Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex

(2016) G. O. Sipe et al.   Nature Communications

Astrocytes contribute to synapse elimination via type 2 inositol 1,4,5-trisphosphate receptor-dependent release of ATP

(2016) Junhua Yang et al.   eLife

Resveratrol Reverses the Synaptic Plasticity Deficits in a Chronic Cerebral Hypoperfusion Rat Model

(2016) Huagang Li et al.   Journal of Stroke & Cerebrovascular Diseases

From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition

(2016) Adam M. H. Young et al.   Molecular Autism

Oxytocin efficacy is modulated by dosage and oxytocin receptor genotype in young adults with high-functioning autism: a 24-week randomized clinical trial

(2016) H Kosaka et al.   Translational Psychiatry

Oxytocin for Male Subjects with Autism Spectrum Disorder and Comorbid Intellectual Disabilities: A Randomized Pilot Study

(2016) Toshio Munesue et al.   Frontiers in Psychiatry

Resveratrol supplementation: Where are we now and where should we go?

(2015) Marta G. Novelle et al.   AGEING RESEARCH REVIEWS

Sculpting Neural Circuits by Axon and Dendrite Pruning

(2015) Martin M. Riccomagno et al.   Annual Review of Cell and Developmental Biology

Serum concentration of 25-hydroxyvitamin D in autism spectrum disorder: a systematic review and meta-analysis

(2015) Tiantian Wang et al.   EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

Sulforaphane is anticonvulsant and improves mitochondrial function

(2015) Catalina Carrasco-Pozo et al.   JOURNAL OF NEUROCHEMISTRY

1,25-Dihydroxyvitamin D3 attenuates endotoxin-induced production of inflammatory mediators by inhibiting MAPK activation in primary cortical neuron-glia cultures

(2015) Ya-Ni Huang et al.   Journal of Neuroinflammation

Sulforaphane Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity by Activating the Keap1-Nrf2-ARE Pathway and Inhibiting the MAPKs and NF-κB Pathways

(2015) Minhee Jang et al.   MOLECULAR NEUROBIOLOGY

The effect of oxytocin nasal spray on social interaction deficits observed in young children with autism: a randomized clinical crossover trial

(2015) C J Yatawara et al.   MOLECULAR PSYCHIATRY

Immune mediators in the brain and peripheral tissues in autism spectrum disorder

(2015) Myka L. Estes et al.   NATURE REVIEWS NEUROSCIENCE

Anterograde C1ql1 Signaling Is Required in Order to Determine and Maintain a Single-Winner Climbing Fiber in the Mouse Cerebellum

(2015) Wataru Kakegawa et al.   NEURON

Microglia: Dynamic Mediators of Synapse Development and Plasticity

(2015) Yuwen Wu et al.   TRENDS IN IMMUNOLOGY

Autism spectrum disorder and low vitamin D at birth: a sibling control study

(2015) Elisabeth Fernell et al.   Molecular Autism

Oxytocin increases eye contact during a real-time, naturalistic social interaction in males with and without autism

(2015) B Auyeung et al.   Translational Psychiatry

NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review

(2015) Ruey-Horng Shih et al.   Frontiers in Molecular Neuroscience

Sulforaphane induces autophagy through ERK activation in neuronal cells

(2014) Chulman Jo et al.   FEBS LETTERS

Effects of astrocyte-targeted production of interleukin-6 in the mouse on the host response to nerve injury

(2014) Beatriz Almolda et al.   GLIA

The effects of a course of intranasal oxytocin on social behaviors in youth diagnosed with autism spectrum disorders: a randomized controlled trial

(2014) Adam J. Guastella et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

The Transcription Factor Nrf2 Is a Therapeutic Target against Brain Inflammation

(2014) N. G. Innamorato et al.   JOURNAL OF IMMUNOLOGY

Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease

(2014) Yanying Liu et al.   JOURNAL OF NEUROCHEMISTRY

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Maternal immune activation and abnormal brain development across CNS disorders

(2014) Irene Knuesel et al.   Nature Reviews Neurology

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

(2014) Guomei Tang et al.   NEURON

Resveratrol prevents social deficits in animal model of autism induced by valproic acid

(2014) Victorio Bambini-Junior et al.   NEUROSCIENCE LETTERS

Core Symptoms of Autism Improved After Vitamin D Supplementation

(2014) F. Jia et al.   PEDIATRICS

Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats

(2014) C. S. Latimer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sulforaphane treatment of autism spectrum disorder (ASD)

(2014) K. Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism

(2014) Claire Piochon et al.   Nature Communications

Costs of Autism Spectrum Disorders in the United Kingdom and the United States

(2014) Ariane V. S. Buescher et al.   JAMA Pediatrics

Altered glial marker expression in autistic post-mortem prefrontal cortex and cerebellum

(2014) Catherine Edmonson et al.   Molecular Autism

DNA methylation analysis of the autistic brain reveals multiple dysregulated biological pathways

(2014) S Nardone et al.   Translational Psychiatry

Vitamin D Activates the Nrf2-Keap1 Antioxidant Pathway and Ameliorates Nephropathy in Diabetic Rats

(2013) K. Nakai et al.   AMERICAN JOURNAL OF HYPERTENSION

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Effects of Intranasal Oxytocin on the Neural Basis of Face Processing in Autism Spectrum Disorder

(2013) Gregor Domes et al.   BIOLOGICAL PSYCHIATRY

Astrocyte-Microglia Cooperation in the Expression of a Pro-Inflammatory Phenotype

(2013) Massimo Barbierato et al.   CNS & Neurological Disorders-Drug Targets

Sulforaphane inhibits growth of phenotypically different breast cancer cells

(2013) Anna Pawlik et al.   EUROPEAN JOURNAL OF NUTRITION

Glial Cells Decipher Synaptic Competition at the Mammalian Neuromuscular Junction

(2013) H. Darabid et al.   JOURNAL OF NEUROSCIENCE

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

(2013) Won-Suk Chung et al.   NATURE

TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement

(2013) Allison R Bialas et al.   NATURE NEUROSCIENCE

Emerging roles of astrocytes in neural circuit development

(2013) Laura E. Clarke et al.   NATURE REVIEWS NEUROSCIENCE

Altered Cytokine and BDNF Levels in Autism Spectrum Disorder

(2013) S. Ricci et al.   NEUROTOXICITY RESEARCH

Oxytocin enhances brain function in children with autism

(2013) I. Gordon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitigation of Sociocommunicational Deficits of Autism Through Oxytocin-Induced Recovery of Medial Prefrontal Activity

(2013) Takamitsu Watanabe et al.   JAMA Psychiatry

The influence of maternal prenatal and early childhood nutrition and maternal prenatal stress on offspring immune system development and neurodevelopmental disorders

(2013) Andrea Horvath Marques et al.   Frontiers in Neuroscience

Abnormal microglial–neuronal spatial organization in the dorsolateral prefrontal cortex in autism

(2012) John T. Morgan et al.   BRAIN RESEARCH

Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease

(2012) Darryl W. Eyles et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Neuroprotective Effects of Sulforaphane after Contusive Spinal Cord Injury

(2012) Andrea L. Benedict et al.   JOURNAL OF NEUROTRAUMA

Neuropeptide Transmission in Brain Circuits

(2012) Anthony N. van den Pol   NEURON

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Implications of Childhood Autism for Parental Employment and Earnings

(2012) Zuleyha Cidav et al.   PEDIATRICS

Parthenolide Inhibits the LPS-induced Secretion of IL-6 and TNF-α and NF-κB Nuclear Translocation in BV-2 Microglia

(2012) Paolo Magni et al.   PHYTOTHERAPY RESEARCH

Modulation of NF-κB activation by resveratrol in LPS treated human intestinal cells results in downregulation of PGE2 production and COX-2 expression

(2012) Antonia Cianciulli et al.   TOXICOLOGY IN VITRO

Microglial Activation in Young Adults With Autism Spectrum Disorder

(2012) Katsuaki Suzuki et al.   JAMA Psychiatry

Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorders: a randomized controlled trial

(2012) Evdokia Anagnostou et al.   Molecular Autism

Resveratrol modulates astroglial functions: neuroprotective hypothesis

(2011) André Quincozes-Santos et al.   Annals of the New York Academy of Sciences

Pharmacological Targeting of the Transcription Factor Nrf2 at the Basal Ganglia Provides Disease Modifying Therapy for Experimental Parkinsonism

(2011) Agnieszka Jazwa et al.   ANTIOXIDANTS & REDOX SIGNALING

Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway

(2011) Miao Yu et al.   CELLULAR SIGNALLING

Autism Spectrum Disorders and Health Care Expenditures

(2011) Georgina Peacock et al.   JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS

IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation

(2011) Hongen Wei et al.   Journal of Neuroinflammation

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

(2011) Irina Voineagu et al.   NATURE

Disrupted Neural Synchronization in Toddlers with Autism

(2011) Ilan Dinstein et al.   NEURON

Plasma Cytokine Profiles in Subjects with High-Functioning Autism Spectrum Disorders

(2011) Katsuaki Suzuki et al.   PLoS One

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Developmental vitamin D deficiency alters learning in C57Bl/6J mice

(2010) Diana Andrea Fernandes de Abreu et al.   BEHAVIOURAL BRAIN RESEARCH

Inhibiting NF-κB activation by small molecules as a therapeutic strategy

(2010) Subash C. Gupta et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Activation of the maternal immune system induces endocrine changes in the placenta via IL-6

(2010) Elaine Y. Hsiao et al.   BRAIN BEHAVIOR AND IMMUNITY

Suppression of NF-κB signaling by KEAP1 regulation of IKKβ activity through autophagic degradation and inhibition of phosphorylation

(2010) Jeong-Eun Kim et al.   CELLULAR SIGNALLING

A big-world network in ASD: Dynamical connectivity analysis reflects a deficit in long-range connections and an excess of short-range connections

(2010) Pablo Barttfeld et al.   NEUROPSYCHOLOGIA

Promoting social behavior with oxytocin in high-functioning autism spectrum disorders

(2010) E. Andari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia

(2010) Julia Kofler et al.   TOXICOLOGIC PATHOLOGY

Intranasal Oxytocin Improves Emotion Recognition for Youth with Autism Spectrum Disorders

(2009) Adam J. Guastella et al.   BIOLOGICAL PSYCHIATRY

Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders

(2009) Jeffrey J. Hutsler et al.   BRAIN RESEARCH

Elevated immune response in the brain of autistic patients

(2009) Xiaohong Li et al.   JOURNAL OF NEUROIMMUNOLOGY

Aripiprazole in the Treatment of Irritability in Children and Adolescents With Autistic Disorder

(2009) R. Owen et al.   PEDIATRICS

Transient prenatal vitamin D deficiency is associated with changes of synaptic plasticity in the dentate gyrus in adult rats

(2009) Gisela Grecksch et al.   PSYCHONEUROENDOCRINOLOGY

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis

(2008) S Nair et al.   BRITISH JOURNAL OF CANCER

Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles

(2008) H. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA