Current knowledge and the future potential of extracellular vesicles in mammalian reproduction

Extracellular Vesicles from Follicular and Ampullary Fluid Isolated by Density Gradient Ultracentrifugation Improve Bovine Embryo Development and Quality

(2021) Anise Asaadi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicles and melatonin benefit embryonic develop by regulating reactive oxygen species and 5‐methylcytosine

(2020) Pengxiang Qu et al.   JOURNAL OF PINEAL RESEARCH

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Metabolism-associated genome-wide epigenetic changes in bovine oocytes during early lactation

(2020) Mikhael Poirier et al.   Scientific Reports

The expression of small RNAs in exosomes of follicular fluid altered in human polycystic ovarian syndrome

(2020) Junhe Hu et al.   PeerJ

In vitro cultured human endometrial cells release extracellular vesicles that can be uptaken by spermatozoa

(2020) Valentina Murdica et al.   Scientific Reports

Placental syncytiotrophoblast extracellular vesicles enter primary endothelial cells through clathrin-mediated endocytosis

(2020) Tina Cronqvist et al.   PLACENTA

Organoid technology in female reproductive biomedicine

(2020) Heidar Heidari-Khoei et al.   Reproductive Biology and Endocrinology

Differential expression profile of plasma exosomal microRNAs in women with polycystic ovary syndrome

(2020) Xiao Jiang et al.   FERTILITY AND STERILITY

Bovine Oviduct Epithelial Cell-Derived Culture Media and Exosomes Improve Mitochondrial Health by Restoring Metabolic Flux during Pre-Implantation Development

(2020) Tabinda Sidrat et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicles shuttle protective messages against heat stress in bovine granulosa cells

(2020) Samuel Gebremedhn et al.   Scientific Reports

Circulating exosomal miR‑125a‑5p as a novel biomarker for cervical cancer

(2020) Aixia Lv et al.   Oncology Letters

Extracellular Vesicles as Mediators of Environmental and Metabolic Stress Coping Mechanisms During Mammalian Follicular Development

(2020) Samuel Gebremedhn et al.   Frontiers in Veterinary Science

PCOS serum-derived exosomal miR-27a-5p stimulates endometrial cancer cells migration and invasion

(2019) Xiaoxia Che et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Extracellular vesicle-coupled miRNA profiles in follicular fluid of cows with divergent post-calving metabolic status

(2019) Tsige Hailay et al.   Scientific Reports

Metabolomic Profile of Oviductal Extracellular Vesicles across the Estrous Cycle in Cattle

(2019) Julie Gatien et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Progesterone effects on extracellular vesicles in the sheep uterus†

(2018) Gregory W Burns et al.   BIOLOGY OF REPRODUCTION

Mechanism of recipient cell-dependent differences in exosome uptake

(2018) Sayo Horibe et al.   BMC CANCER

Extracellular Vesicles in Human Reproduction in Health and Disease

(2018) Carlos Simon et al.   ENDOCRINE REVIEWS

Identification of altered microRNAs in serum of a mouse model of Parkinson’s disease

(2018) Hector Rosas-Hernandez et al.   NEUROSCIENCE LETTERS

Bovine oviductal and uterine fluid support in vitro embryo development

(2018) Meriem Hamdi et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Oxidative and endoplasmic reticulum stress defense mechanisms of bovine granulosa cells exposed to heat stress

(2018) Teshome Wondie Alemu et al.   THERIOGENOLOGY

Monitoring Extracellular Vesicle Cargo Active Uptake by Imaging Flow Cytometry

(2018) Yifat Ofir-Birin et al.   Frontiers in Immunology

Deciphering the oviductal extracellular vesicles content across the estrous cycle: implications for the gametes-oviduct interactions and the environment of the potential embryo

(2018) C. Almiñana et al.   BMC GENOMICS

Circulating miRNAs as Potential Biomarkers in Alzheimer's Disease

(2018) Daniela Galimberti et al.   JOURNAL OF ALZHEIMERS DISEASE

Low Oxygen Levels Induce Early Luteinization Associated Changes in Bovine Granulosa Cells

(2018) Vijay S. Baddela et al.   Frontiers in Physiology

Detection of extracellular vesicles in the mouse vaginal fluid: Their delivery of sperm proteins that stimulate capacitation and modulate fertility

(2018) Zeinab Fereshteh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice

(2018) Carlos Castaño et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Heat Stress on Reproduction in Dairy Cows: Insights into the Cellular and Molecular Responses of the Oocyte

(2017) Zvi Roth   Annual Review of Animal Biosciences

Cellular and exosome mediated molecular defense mechanism in bovine granulosa cells exposed to oxidative stress

(2017) Mohammed Saeed-Zidane et al.   PLoS One

Exosomes: Fundamental Biology and Roles in Cardiovascular Physiology

(2016) Ahmed Ibrahim et al.   Annual Review of Physiology

Human Endometrial Exosomes Contain Hormone-Specific Cargo Modulating Trophoblast Adhesive Capacity: Insights into Endometrial-Embryo Interactions1

(2016) David W. Greening et al.   BIOLOGY OF REPRODUCTION

Extracellular Vesicles Originate from the Conceptus and Uterus During Early Pregnancy in Sheep1

(2016) Gregory W. Burns et al.   BIOLOGY OF REPRODUCTION

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Comparing the effects of heat stress and mastitis on ovarian function in lactating cows: basic and applied aspects

(2016) Z. Roth et al.   DOMESTIC ANIMAL ENDOCRINOLOGY

Extracellular Vesicles from BOEC in In Vitro Embryo Development and Quality

(2016) Ricaurte Lopera-Vásquez et al.   PLoS One

Effects of chronic heat stress on granulosa cell apoptosis and follicular atresia in mouse ovary

(2016) Jieyun Li et al.   Journal of Animal Science and Biotechnology

Deep sequencing identifies circulating mouse miRNAs that are functionally implicated in manifestations of aging and responsive to calorie restriction

(2016) Joseph M Dhahbi et al.   Aging-US

Autocrine embryotropins revisited: how do embryos communicate with each other in vitro when cultured in groups?

(2015) Eline Wydooghe et al.   BIOLOGICAL REVIEWS

Extracellular Vesicles from Bovine Follicular Fluid Support Cumulus Expansion1

(2015) Wei-Ting Hung et al.   BIOLOGY OF REPRODUCTION

A panel of four decreased serum microRNAs as a novel biomarker for early Parkinson’s disease

(2015) Hui Dong et al.   BIOMARKERS

Hsa-miR-30d, secreted by the human endometrium, is taken up by the pre-implantation embryo and might modify its transcriptome

(2015) F. Vilella et al.   DEVELOPMENT

Identification of Circulating miR-101, miR-375 and miR-802 as Biomarkers for Type 2 Diabetes

(2015) Chigusa Higuchi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Diagnosis by extracellular vesicles

(2015) Clotilde Théry   NATURE

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters

(2015) Charles P. Lai et al.   Nature Communications

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Identification and bioinformatics analysis of microRNAs associated with stress and immune response in serum of heat-stressed and normal Holstein cows

(2014) Yue Zheng et al.   CELL STRESS & CHAPERONES

Improvement of Cloned Embryos Development by Co-Culturing with Parthenotes: A Possible Role of Exosomes/Microvesicles for Embryos Paracrine Communication

(2014) Islam M. Saadeldin et al.   Cellular Reprogramming

Molecular characterization of exosomes and their microRNA cargo in human follicular fluid: bioinformatic analysis reveals that exosomal microRNAs control pathways involved in follicular maturation

(2014) Manuela Santonocito et al.   FERTILITY AND STERILITY

Hyperthermia Induces Apoptosis through Endoplasmic Reticulum and Reactive Oxygen Species in Human Osteosarcoma Cells

(2014) Chun-Han Hou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prognostic serum miRNA biomarkers associated with Alzheimer’s disease shows concordance with neuropsychological and neuroimaging assessment

(2014) L Cheng et al.   MOLECULAR PSYCHIATRY

Extracellular Vesicles in Luminal Fluid of the Ovine Uterus

(2014) Gregory Burns et al.   PLoS One

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Sorting it out: Regulation of exosome loading

(2014) Carolina Villarroya-Beltri et al.   SEMINARS IN CANCER BIOLOGY

Transcriptome analysis of bovine granulosa cells of preovulatory follicles harvested 30, 60, 90, and 120 days postpartum

(2014) V.E. Golini et al.   THERIOGENOLOGY

Age-associated differential microRNA levels in human follicular fluid reveal pathways potentially determining fertility and success ofin vitrofertilization

(2014) Araceli Diez-Fraile et al.   Human Fertility

Exosomes and Autophagy: Coordinated Mechanisms for the Maintenance of Cellular Fitness

(2014) Francesc Baixauli et al.   Frontiers in Immunology

Epididymosomes Convey Different Repertoires of MicroRNAs Throughout the Bovine Epididymis1

(2013) Clémence Belleannée et al.   BIOLOGY OF REPRODUCTION

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Characterization and proteomic analysis of ovarian cancer-derived exosomes

(2013) Bing Liang et al.   Journal of Proteomics

Morphological and cytogenetic assessment of cleavage and blastocyst stage embryos

(2013) E. Fragouli et al.   MOLECULAR HUMAN REPRODUCTION

Endometrial Exosomes/Microvesicles in the Uterine Microenvironment: A New Paradigm for Embryo-Endometrial Cross Talk at Implantation

(2013) York Hunt Ng et al.   PLoS One

Meta-Analysis Using a Novel Database, miRStress, Reveals miRNAs That Are Frequently Associated with the Radiation and Hypoxia Stress-Responses

(2013) Laura Ann Jacobs et al.   PLoS One

Exosomal and Non-Exosomal Transport of Extra-Cellular microRNAs in Follicular Fluid: Implications for Bovine Oocyte Developmental Competence

(2013) Md. Mahmodul Hasan Sohel et al.   PLoS One

Expression and Secretion of Plasma Membrane Ca2+-ATPase 4a (PMCA4a) during Murine Estrus: Association with Oviductal Exosomes and Uptake in Sperm

(2013) Amal A. Al-Dossary et al.   PLoS One

Epididymosomes, prostasomes, and liposomes: their roles in mammalian male reproductive physiology

(2013) Robert Sullivan et al.   REPRODUCTION

Trash or Treasure: extracellular microRNAs and cell-to-cell communication

(2013) Nobuyoshi Kosaka et al.   Frontiers in Genetics

The Myxovirus-Resistance Protein, MX1, is a Component of Exosomes Secreted by Uterine Epithelial Cells

(2012) Karen Racicot et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Diabetes in Older Adults

(2012) M. S. Kirkman et al.   DIABETES CARE

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

(2012) M. Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of the oviduct in mammalian fertilization

(2012) P Coy et al.   REPRODUCTION

Follicular fluid supplementation during in vitro maturation promotes sperm penetration in bovine oocytes by enhancing cumulus expansion and increasing mitochondrial activity in oocytes

(2012) Tamás Somfai et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Maternal Communication with Gametes and Embryo: A Personal Opinion

(2012) A Fazeli   REPRODUCTION IN DOMESTIC ANIMALS

The effects of oxidative stress on female reproduction: a review

(2012) Ashok Agarwal et al.   Reproductive Biology and Endocrinology

Developmental competence in oocytes and cumulus cells: candidate genes and networks

(2012) Lynne C. O'Shea et al.   Systems Biology in Reproductive Medicine

Delivery of chemotherapeutic drugs in tumour cell-derived microparticles

(2012) Ke Tang et al.   Nature Communications

Multivesicular Body Morphogenesis

(2011) Phyllis I. Hanson et al.   Annual Review of Cell and Developmental Biology

Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle1

(2011) Juliano C. da Silveira et al.   BIOLOGY OF REPRODUCTION

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes

(2011) A. Montecalvo et al.   BLOOD

Interaction and uptake of exosomes by ovarian cancer cells

(2011) Cristina Escrevente et al.   BMC CANCER

Lipid mobilization and inflammatory responses during the transition period of dairy cows

(2011) G. Andres Contreras et al.   COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

Body fluid derived exosomes as a novel template for clinical diagnostics

(2011) Sascha Keller et al.   Journal of Translational Medicine

Novel signaling mechanisms in the ovary during oocyte maturation and ovulation

(2011) Marco Conti et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Connexins: Key Mediators of Endocrine Function

(2011) Domenico Bosco et al.   PHYSIOLOGICAL REVIEWS

Reactive oxygen species are indispensable in ovulation

(2011) K. Shkolnik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effects of cysteine addition during in vitro maturation on the developmental competence, ROS, GSH and apoptosis level of bovine oocytes exposed to heat stress

(2011) Hisashi Nabenishi et al.   ZYGOTE

Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: a clinical study

(2010) Lei Kong et al.   ACTA DIABETOLOGICA

Oxidative stress

(2010) Graham J. Burton et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: A form of communication during injury, infection, and cell damage

(2010) Antonio De Maio   CELL STRESS & CHAPERONES

Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling

(2010) Arthit Chairoungdua et al.   JOURNAL OF CELL BIOLOGY

Oviductal secretions: will they be key factors for the future ARTs?

(2010) Manuel Avilés et al.   MOLECULAR HUMAN REPRODUCTION

Exosomes Communicate Protective Messages during Oxidative Stress; Possible Role of Exosomal Shuttle RNA

(2010) Maria Eldh et al.   PLoS One

The Well-of-the-Well system: an efficient approach to improve embryo development

(2010) Gábor Vajta et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Group culture of human zygotes is superior to individual culture in terms of blastulation, implantation and life birth

(2010) T. Ebner et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Heat shock protein 70 is secreted from endothelial cells by a non-classical pathway involving exosomes

(2009) Rui Zhan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

The potential roles for embryotrophic ligands in preimplantation embryo development

(2008) Chris O’Neill   HUMAN REPRODUCTION UPDATE

Female reproductive tract fluids: composition, mechanism of formation and potential role in the developmental origins of health and disease

(2008) Henry J. Leese et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Comparison of embryo yield and pregnancy rate between in vivo and in vitro methods in the same Nelore (Bos indicus) donor cows

(2008) J.H.F. Pontes et al.   THERIOGENOLOGY