Biochemical autoregulatory gene therapy for focal epilepsy

Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs

(2018) Zhibin Chen et al.   JAMA Neurology

Eliminating HIV-1 Packaging Sequences from Lentiviral Vector Proviruses Enhances Safety and Expedites Gene Transfer for Gene Therapy

(2017) Conrad A. Vink et al.   MOLECULAR THERAPY

Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers

(2017) Fei Tang et al.   Frontiers in Neurology

50 Hz hippocampal stimulation in refractory epilepsy: Higher level of basal glutamate predicts greater release of glutamate

(2016) Idil Cavus et al.   EPILEPSIA

Reduced tonic inhibition after stroke promotes motor performance and epileptic seizures

(2016) Nadine Jaenisch et al.   Scientific Reports

Ictal perfusion changes associated with seizure progression in the amygdala kindling model in the rhesus monkey

(2015) Evy Cleeren et al.   EPILEPSIA

Glutamatergic Mechanisms Associated with Seizures and Epilepsy

(2015) Melissa Barker-Haliski et al.   Cold Spring Harbor Perspectives in Medicine

Tonic glutamate in CA1 of aging rats correlates with phasic glutamate dysregulation during seizure

(2014) Michelle L. Stephens et al.   EPILEPSIA

Epilepsy surgery in children and adults

(2014) Philippe Ryvlin et al.   LANCET NEUROLOGY

Gene therapy in epilepsy—is it time for clinical trials?

(2014) Dimitri M. Kullmann et al.   Nature Reviews Neurology

Chemical–genetic attenuation of focal neocortical seizures

(2014) Dennis Kätzel et al.   Nature Communications

An Engineered Glutamate-gated Chloride (GluCl) Channel for Sensitive, Consistent Neuronal Silencing by Ivermectin

(2013) Shawnalea J. Frazier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prediction of seizure likelihood with a long-term, implanted seizure advisory system in patients with drug-resistant epilepsy: a first-in-man study

(2013) Mark J Cook et al.   LANCET NEUROLOGY

Characterization of the Properties of Seven Promoters in the Motor Cortex of Rats and Monkeys After Lentiviral Vector-Mediated Gene Transfer

(2013) Masae Yaguchi et al.   Human Gene Therapy Methods

Tetanus neurotoxin-induced epilepsy in mouse visual cortex

(2012) Marco Mainardi et al.   EPILEPSIA

Adverse effects of antiepileptic drugs

(2012) Piero Perucca et al.   LANCET NEUROLOGY

Optogenetic and Potassium Channel Gene Therapy in a Rodent Model of Focal Neocortical Epilepsy

(2012) R. C. Wykes et al.   Science Translational Medicine

Glutamate release by primary brain tumors induces epileptic activity

(2011) Susan C Buckingham et al.   NATURE MEDICINE

Drug-Resistant Epilepsy

(2011) Patrick Kwan et al.   NEW ENGLAND JOURNAL OF MEDICINE