Metformin attenuates osteoclast-mediated abnormal subchondral bone remodeling and alleviates osteoarthritis via AMPK/NF-κB/ERK signaling pathway

Metformin Hydrochloride Encapsulation by Alginate Strontium Hydrogel for Cartilage Regeneration by Reliving Cellular Senescence

(2021) Lei Xu et al.   BIOMACROMOLECULES

Association Analysis of Insulin Resistance and Osteoporosis Risk in Chinese Patients with T2DM

(2021) Xinshui Wang et al.   Therapeutics and Clinical Risk Management

Metformin coordinates osteoblast/osteoclast differentiation associated with ischemic osteonecrosis

(2020) See-Hyoung Park et al.   Aging-US

Initiating factors for the onset of OA: A systematic review of animal bone and cartilage pathology in OA

(2020) Michelle E. Casper‐Taylor et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Metformin limits osteoarthritis development and progression through activation of AMPK signalling

(2020) Jun Li et al.   ANNALS OF THE RHEUMATIC DISEASES

Effect of Intravenous Zoledronic Acid on Tibiofemoral Cartilage Volume Among Patients With Knee Osteoarthritis With Bone Marrow Lesions

(2020) Guoqi Cai et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A natural compound (LCA) isolated from Litsea cubeba inhibits RANKL-induced osteoclast differentiation by suppressing Akt and MAPK pathways in mouse bone marrow macrophages

(2020) Luyao Yu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Metformin Mitigates Cartilage Degradation by Activating AMPK/SIRT1-Mediated Autophagy in a Mouse Osteoarthritis Model

(2020) Chenzhong Wang et al.   Frontiers in Pharmacology

Metformin inhibits inflammation and bone destruction in collagen- induced arthritis in rats

(2020) Kai-Jian Fan et al.   Annals of Translational Medicine

Therapeutic Options Targeting Oxidative Stress, Mitochondrial Dysfunction and Inflammation to Hinder the Progression of Vascular Complications of Diabetes

(2019) João S. Teodoro et al.   Frontiers in Physiology

Metformin‐induced autophagy and irisin improves INS‐1 cell function and survival in high‐glucose environment via AMPK/SIRT1/PGC‐1α signal pathway

(2019) Qingxue Li et al.   Food Science & Nutrition

Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)

(2019) Emmanuel Biver et al.   AGEING RESEARCH REVIEWS

Bone matrix microdamage and vascular changes characterize bone marrow lesions in the subchondral bone of knee osteoarthritis

(2018) Dzenita Muratovic et al.   BONE

AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice

(2017) Sheng Zhou et al.   Scientific Reports

Selective Regulation of MAPK Signaling Mediates RANKL-dependent Osteoclast Differentiation

(2016) Kyunghee Lee et al.   International Journal of Biological Sciences

Emerging role of metabolic signaling in synovial joint remodeling and osteoarthritis

(2016) Ronald K. June et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage–bone crosstalk

(2016) Steven R. Goldring et al.   Nature Reviews Rheumatology

Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo

(2016) Deheng Chen et al.   Cell Death & Disease

Dihydroartemisinin prevents breast cancer-induced osteolysis via inhibiting both breast caner cells and osteoclasts

(2016) Ming-Xuan Feng et al.   Scientific Reports

Animal models of osteoarthritis: classification, update, and measurement of outcomes

(2016) Emmanuel L. Kuyinu et al.   Journal of Orthopaedic Surgery and Research

Osteoarthritis

(2016) Johanne Martel-Pelletier et al.   Nature Reviews Disease Primers

Extracts from Aralia elata (Miq) Seem alleviate hepatosteatosis via improving hepatic insulin sensitivity

(2015) Kyung-A Hwang et al.   BMC Complementary and Alternative Medicine

Osteoclasts on Bone and Dentin In Vitro: Mechanism of Trail Formation and Comparison of Resorption Behavior

(2013) M. Rumpler et al.   CALCIFIED TISSUE INTERNATIONAL

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE