Metformin Mitigates Cartilage Degradation by Activating AMPK/SIRT1-Mediated Autophagy in a Mouse Osteoarthritis Model

Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR

(2020) Xiaofeng Feng et al.   Aging-US

Exploration of CRISPR/Cas9-based gene editing as therapy for osteoarthritis

(2019) Lan Zhao et al.   ANNALS OF THE RHEUMATIC DISEASES

Autophagy regulates apoptosis by targeting NOXA for degradation

(2018) Jingchao Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Metformin reverses established lung fibrosis in a bleomycin model

(2018) Sunad Rangarajan et al.   NATURE MEDICINE

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

Sirt1-Sirt3 axis regulates human blood-brain barrier permeability in response to ischemia

(2018) Tao Chen et al.   Redox Biology

Interleukin-1β signaling in osteoarthritis – chondrocytes in focus

(2018) Zsuzsa Jenei-Lanzl et al.   CELLULAR SIGNALLING

The interaction of Atg4B and Bcl-2 plays an important role in Cd-induced crosstalk between apoptosis and autophagy through disassociation of Bcl-2-Beclin1 in A549 cells

(2018) Zhiguo Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1/Parkin-dependent mitophagy in primary chondrocytes

(2018) Chenzhong Wang et al.   BioScience Trends

Local intra-articular injection of resveratrol delays cartilage degeneration in C57BL/6 mice by inducing autophagy via AMPK/mTOR pathway

(2017) Na Qin et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice

(2017) Sheng Zhou et al.   Scientific Reports

Chondrocyte-Specific Ablation ofAMPKα1Does Not Affect Bone Development or Pathogenesis of Osteoarthritis in Mice

(2016) Cheng Yang et al.   DNA AND CELL BIOLOGY

Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo

(2016) Deheng Chen et al.   Cell Death & Disease

Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis

(2015) Giuseppe Musumeci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway

(2014) Young Mi Song et al.   Autophagy

Metformin—mode of action and clinical implications for diabetes and cancer

(2014) Ida Pernicova et al.   Nature Reviews Endocrinology

Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice

(2013) Tokio Matsuzaki et al.   ANNALS OF THE RHEUMATIC DISEASES

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Histopathology of naturally occurring and surgically induced osteoarthritis in mice

(2012) M.A. McNulty et al.   OSTEOARTHRITIS AND CARTILAGE

Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy

(2012) W-Y Shi et al.   Cell Death & Disease

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

(2011) Beatriz Caramés et al.   ANNALS OF THE RHEUMATIC DISEASES

Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α

(2011) Robert Terkeltaub et al.   ARTHRITIS AND RHEUMATISM

Autophagy modulates osteoarthritis-related gene expression in human chondrocytes

(2011) Hiroshi Sasaki et al.   ARTHRITIS AND RHEUMATISM

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA

(2011) Martin K. Lotz et al.   Nature Reviews Rheumatology

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model

(2010) Yu Wang et al.   FEBS LETTERS

Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5

(2010) Paul W Caton et al.   JOURNAL OF ENDOCRINOLOGY

Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions

(2010) Norifumi Fujita et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

(2010) Masato Iwabu et al.   NATURE

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway

(2010) Mary D. L. Chau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE