Intratumoral expression of IL-12 from lentiviral or RNA vectors acts synergistically with TLR4 agonist (GLA) to generate anti-tumor immunological memory

Oncolytic Virus-based Cytokine Expression to Improve Immune Activity in Brain and Solid Tumors

(2019) Taylor M. Pearl et al.   Molecular Therapy-Oncolytics

Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs

(2019) Susannah L. Hewitt et al.   Science Translational Medicine

The Immunobiology of the Interleukin-12 Family: Room for Discovery

(2019) Elia D. Tait Wojno et al.   IMMUNITY

Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy

(2019) Noor Momin et al.   Science Translational Medicine

Tumor-targeted IL-12 combined with tumor resection yields a survival-favorable immune profile

(2019) Qingnan Zhao et al.   Journal for ImmunoTherapy of Cancer

Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial

(2019) E. Antonio Chiocca et al.   Science Translational Medicine

Intratumoral Delivery of Plasmid IL12 Via Electroporation Leads to Regression of Injected and Noninjected Tumors in Merkel Cell Carcinoma

(2019) Shailender Bhatia et al.   CLINICAL CANCER RESEARCH

Regulated intratumoral expression of IL-12 using a RheoSwitch Therapeutic System® (RTS®) gene switch as gene therapy for the treatment of glioma

(2018) John A. Barrett et al.   CANCER GENE THERAPY

Revisiting Interleukin-12 as a Cancer Immunotherapy Agent

(2018) Pedro Berraondo et al.   CLINICAL CANCER RESEARCH

Improving therapeutic efficacy of IL-12 intratumoral gene electrotransfer through novel plasmid design and modified parameters

(2018) C. Burkart et al.   GENE THERAPY

Characterization of abscopal effects of intratumoral electroporation-mediated IL-12 gene therapy

(2018) Anandaroop Mukhopadhyay et al.   GENE THERAPY

Correlates of GLA family adjuvants’ activities

(2018) Steven G. Reed et al.   SEMINARS IN IMMUNOLOGY

Polyethylenimine-based micro/nanoparticles as vaccine adjuvants

(2017) Chen Shen et al.   International Journal of Nanomedicine

Pretreatment of activated human CD8 T cells with IL-12 leads to enhanced TCR-induced signaling and cytokine production

(2017) Aldo Vacaflores et al.   MOLECULAR IMMUNOLOGY

HIV-1 Conserved Mosaics Delivered by Regimens with Integration-Deficient DC-Targeting Lentiviral Vector Induce Robust T Cells

(2017) Edmund G. Wee et al.   MOLECULAR THERAPY

Tumor-targeted IL-12 combined with local irradiation leads to systemic tumor control via abscopal effects in vivo

(2017) Franziska Eckert et al.   OncoImmunology

IL-12 stimulates CTLs to secrete exosomes capable of activating bystander CD8+ T cells

(2017) Lei Li et al.   Scientific Reports

Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis

(2016) Isabel Ohs et al.   Nature Communications

IL-12 Expressing oncolytic herpes simplex virus promotes anti-tumor activity and immunologic control of metastatic ovarian cancer in mice

(2016) Eric D. Thomas et al.   Journal of Ovarian Research

LV305, a dendritic cell-targeting integration-deficient ZVex TM -based lentiviral vector encoding NY-ESO-1, induces potent anti-tumor immune response

(2016) Tina Chang Albershardt et al.   Molecular Therapy-Oncolytics

Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism

(2016) Aldo Vacaflores et al.   PLoS One

Lentiviral vectors in cancer immunotherapy

(2015) Robyn AA Oldham et al.   Immunotherapy

Virological and Preclinical Characterization of a Dendritic Cell Targeting, Integration-deficient Lentiviral Vector for Cancer Immunotherapy

(2015) Jared M. Odegard et al.   JOURNAL OF IMMUNOTHERAPY

IL-12 Augments Antitumor Responses to Cycled Chemotherapy

(2015) Lingbing Zhang et al.   JOURNAL OF IMMUNOTHERAPY

Virotherapy with a Semliki Forest Virus–Based Vector Encoding IL12 Synergizes with PD-1/PD-L1 Blockade

(2015) José I. Quetglas et al.   Cancer Immunology Research

Interleukin 12: still a promising candidate for tumor immunotherapy?

(2014) Witold Lasek et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

New insights into IL-12-mediated tumor suppression

(2014) S Tugues et al.   CELL DEATH AND DIFFERENTIATION

Squalene emulsion potentiates the adjuvant activity of the TLR4 agonist, GLA, via inflammatory caspases, IL-18, and IFN-γ

(2014) Anthony L. Desbien et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Phase I trial of a formulated IL-12 plasmid in combination with carboplatin and docetaxel chemotherapy in the treatment of platinum-sensitive recurrent ovarian cancer

(2013) Khursheed Anwer et al.   GYNECOLOGIC ONCOLOGY

Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell–mediated glioma rejection

(2013) Johannes vom Berg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Design of a Novel Integration-deficient Lentivector Technology That Incorporates Genetic and Posttranslational Elements to Target Human Dendritic Cells

(2013) Semih U Tareen et al.   MOLECULAR THERAPY

Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning

(2012) H. J. Pegram et al.   BLOOD

Differential Effects of IL-12 on Tregs and Non-Treg T Cells: Roles of IFN-γ, IL-2 and IL-2R

(2012) Jingxian Zhao et al.   PLoS One

IL-12 selectively programs effector pathways that are stably expressed in human CD8+ effector memory T cells in vivo

(2011) F. Z. Chowdhury et al.   BLOOD

A new synthetic TLR4 agonist, GLA, allows dendritic cells targeted with antigen to elicit Th1 T-cell immunity in vivo

(2011) Austin Pantel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The role of interleukin-12 on modulating myeloid-derived suppressor cells, increasing overall survival and reducing metastasis

(2011) Catherine E. Steding et al.   IMMUNOLOGY

IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors

(2011) Sid P. Kerkar et al.   JOURNAL OF CLINICAL INVESTIGATION

Development and Characterization of Synthetic Glucopyranosyl Lipid Adjuvant System as a Vaccine Adjuvant

(2011) Rhea N. Coler et al.   PLoS One

Defect of CD8+ Memory T Cells Developed in Absence of IL-12 Priming for Secondary Expansion

(2010) Zhenmin Ye et al.   Cellular & Molecular Immunology

Intratumoral Immunotherapy of Established Solid Tumors With Chitosan/IL-12

(2010) David A. Zaharoff et al.   JOURNAL OF IMMUNOTHERAPY

Intratumoral IL-12 Gene Therapy Results in the Crosspriming of Tc1 Cells Reactive Against Tumor-associated Stromal Antigens

(2010) Xi Zhao et al.   MOLECULAR THERAPY

Cancer gene therapy by IL-12 gene delivery using liposomal bubbles and tumoral ultrasound exposure

(2009) Ryo Suzuki et al.   JOURNAL OF CONTROLLED RELEASE

Programming for CD8 T Cell Memory Development Requires IL-12 or Type I IFN

(2009) Z. Xiao et al.   JOURNAL OF IMMUNOLOGY

Phase I Trial of Interleukin-12 Plasmid Electroporation in Patients With Metastatic Melanoma

(2008) Adil I. Daud et al.   JOURNAL OF CLINICAL ONCOLOGY

An IFN-γ-IL-18 Signaling Loop Accelerates Memory CD8+ T Cell Proliferation

(2008) Yoshiko Iwai et al.   PLoS One