Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism

Metabolic plasticity of human T cells: Preserved cytokine production under glucose deprivation or mitochondrial restriction, but 2-deoxy-glucose affects effector functions

(2015) Kathrin Renner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TCR-mediated functions are enhanced in activated peripheral blood T cells isolated from leucocyte reduction systems

(2015) Mikaela M. Tremblay et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Increased Th1 and suppressed Th2 serum cytokine levels in subjects with diabetic coronary artery disease

(2014) Haridoss Madhumitha et al.   Cardiovascular Diabetology

New insights into IL-12-mediated tumor suppression

(2014) S Tugues et al.   CELL DEATH AND DIFFERENTIATION

Activated PLC-γ1 is catalytically induced at LAT but activated PLC-γ1 is localized at both LAT- and TCR-containing complexes

(2014) Noemi Cruz-Orcutt et al.   CELLULAR SIGNALLING

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

Dynamic Functional Modulation of CD4+ T Cell Recall Responses Is Dependent on the Inflammatory Environment of the Secondary Stimulus

(2014) Chulwoo Kim et al.   PLoS Pathogens

Plasticity of Human CD4 T Cell Subsets

(2014) Jens Geginat et al.   Frontiers in Immunology

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Human Monocyte-Derived Dendritic Cells Exposed to Microorganisms Involved in Hypersensitivity Pneumonitis Induce a Th1-Polarized Immune Response

(2013) Anne-Pauline Bellanger et al.   Clinical and Vaccine Immunology

Focal Adhesion Kinase Negatively Regulates Lck Function Downstream of the T Cell Antigen Receptor

(2013) N. M. Chapman et al.   JOURNAL OF IMMUNOLOGY

IL-7- and IL-15-Mediated TCR Sensitization Enables T Cell Responses to Self-Antigens

(2013) P. Deshpande et al.   JOURNAL OF IMMUNOLOGY

Prior TLR5 induction in human T cells results in a transient potentiation of subsequent TCR-induced cytokine production

(2013) Mikaela M. Tremblay et al.   MOLECULAR IMMUNOLOGY

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

(2013) Patrick M Gubser et al.   NATURE IMMUNOLOGY

The CD4-centered universe of human T cell subsets

(2013) J. Geginat et al.   SEMINARS IN IMMUNOLOGY

The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

(2012) Arvand Haschemi et al.   Cell Metabolism

Pathogen-Specific Inflammatory Milieux Tune the Antigen Sensitivity of CD8+ T Cells by Enhancing T Cell Receptor Signaling

(2012) Martin J. Richer et al.   IMMUNITY

Cytokine-Mediated Programmed Proliferation of Virus-Specific CD8+ Memory T Cells

(2012) Hans-Peter Raué et al.   IMMUNITY

Possible roles of IL-12-family cytokines in rheumatoid arthritis

(2012) Richard M. Pope et al.   Nature Reviews Rheumatology

The rate of oxygen utilization by cells

(2011) Brett A. Wagner et al.   FREE RADICAL BIOLOGY AND MEDICINE

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Inflammatory cytokines as a third signal for T cell activation

(2010) Julie M Curtsinger et al.   CURRENT OPINION IN IMMUNOLOGY

T cell receptor activation leads to two distinct phases of Pyk2 activation and actin cytoskeletal rearrangement in human T cells

(2010) Michaela Collins et al.   MOLECULAR IMMUNOLOGY

Effector T cell plasticity: flexibility in the face of changing circumstances

(2010) Kenneth M Murphy et al.   NATURE IMMUNOLOGY

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells

(2010) J. J. O'Shea et al.   SCIENCE

T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance

(2009) Robert J. Salmond et al.   IMMUNOLOGICAL REVIEWS

The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems

(2009) Michaela Collins et al.   JOURNAL OF LEUKOCYTE BIOLOGY

PI3 kinase function is vital for the function but not formation of LAT-mediated signaling complexes

(2009) Noemi Cruz-Orcutt et al.   MOLECULAR IMMUNOLOGY

Comparison of T Cell Receptor-Induced Proximal Signaling and Downstream Functions in Immortalized and Primary T Cells

(2009) Rebekah R. Bartelt et al.   PLoS One