Senotherapeutic-like effect of Silybum marianum flower extract revealed on human skin cells

Senolytics for Cancer Therapy: Is All that Glitters Really Gold?

(2021) Valerie J. Carpenter et al.   Cancers

The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice

(2020) Birgit Ritschka et al.   GENES & DEVELOPMENT

Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

(2020) Estela González‐Gualda et al.   AGING CELL

An Appraisal on the Value of Using Nutraceutical Based Senolytics and Senostatics in Aging

(2020) Amanpreet Kaur et al.   Frontiers in Cell and Developmental Biology

Obesity is associated with senescence of mesenchymal stromal cells derived from bone marrow, subcutaneous and visceral fat of young mice

(2020) Nicola Alessio et al.   Aging-US

Breed-related expression patterns of Ki67, γH2AX, and p21 during ageing in the canine liver

(2020) Laura J. A. Hardwick et al.   VETERINARY RESEARCH COMMUNICATIONS

AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts

(2019) Anna Lewinska et al.   Redox Biology

Hsp90 inhibitors as senolytic drugs to extend healthy aging

(2018) Heike Fuhrmann-Stroissnigg et al.   CELL CYCLE

Mechanisms and functions of cellular senescence

(2018) Nicolás Herranz et al.   JOURNAL OF CLINICAL INVESTIGATION

Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy

(2018) Marco Malavolta et al.   MEDIATORS OF INFLAMMATION

Effects of senolytic drugs on human mesenchymal stromal cells

(2018) Clara Grezella et al.   Stem Cell Research & Therapy

Senescent fibroblasts drive ageing pigmentation: ​A potential therapeutic target for senile lentigo

(2018) Jung Eun Yoon et al.   Theranostics

Biomarkers of Cellular Senescence and Skin Aging

(2018) Audrey S. Wang et al.   Frontiers in Genetics

Fisetin is a senotherapeutic that extends health and lifespan

(2018) Matthew J. Yousefzadeh et al.   EBioMedicine

Combined Virtual and Experimental Screening for CK1 Inhibitors Identifies a Modulator of p53 and Reveals Important Aspects of in Silico Screening Performance

(2017) Vassilios Myrianthopoulos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Clinical Potential of Senolytic Drugs

(2017) James L. Kirkland et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

Cellular Senescence: A Translational Perspective

(2017) James L. Kirkland et al.   EBioMedicine

The Dual Role of Cellular Senescence in Developing Tumors and Their Response to Cancer Therapy

(2017) Markus Schosserer et al.   Frontiers in Oncology

Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells

(2017) Kevin M. Perrott et al.   GeroScience

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycin-induced senescence in BJ fibroblasts

(2015) Hyun Lim et al.   BIOCHEMICAL PHARMACOLOGY

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity

(2015) Saima Jadoon et al.   Oxidative Medicine and Cellular Longevity

Resveratrol Induced Premature Senescence Is Associated with DNA Damage Mediated SIRT1 and SIRT2 Down-Regulation

(2015) Mehtap Kilic Eren et al.   PLoS One

ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer

(2015) Qiongrong Chen et al.   Oncotarget

Nuclear DNA Methylation and Chromatin Condensation Phenotypes Are Distinct Between Normally Proliferating/Aging, Rapidly Growing/Immortal, and Senescent Cells

(2015) Jin Ho Oh et al.   Oncotarget

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Co-culture with human fetal epidermal keratinocytes promotes proliferation and migration of human fetal and adult dermal fibroblasts

(2014) ZHE WANG et al.   Molecular Medicine Reports

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

(2013) Olga Moiseeva et al.   AGING CELL

Senescent Fibroblasts Enhance Early Skin Carcinogenic Events via a Paracrine MMP-PAR-1 Axis

(2013) Nicolas Malaquin et al.   PLoS One

Prognostic Value and Targeted Inhibition of Survivin Expression in Esophageal Adenocarcinoma and Cancer-Adjacent Squamous Epithelium

(2013) Usha Malhotra et al.   PLoS One

Cysteine-rich protein 61 (CCN1) mediates replicative senescence-associated aberrant collagen homeostasis in human skin fibroblasts

(2012) Taihao Quan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Anti-apoptotic and anti-inflammatory effects of Silybum marianum in treatment of experimental steatohepatitis

(2010) Safiyeh Aghazadeh et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

The IGF-1/IGF-1R signaling axis in the skin: a new role for the dermis in aging-associated skin cancer

(2009) D A Lewis et al.   ONCOGENE