RasGRP1 is a causal factor in the development of l-DOPA–induced dyskinesia in Parkinson’s disease

The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson’s disease patients

(2019) Tommaso Nuzzo et al.   Scientific Reports

A Selective Phosphodiesterase 10A Inhibitor Reduces L -Dopa-Induced Dyskinesias in Parkinsonian Monkeys

(2018) Goichi Beck et al.   MOVEMENT DISORDERS

Aberrant Striatal Activity in Parkinsonism and Levodopa-Induced Dyskinesia

(2018) Michael B. Ryan et al.   Cell Reports

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Human COMT over-expression confers a heightened susceptibility to dyskinesia in mice

(2017) Oscar Solís et al.   NEUROBIOLOGY OF DISEASE

A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton

(2016) Erin Janssen et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic deletion of Rhes or pharmacological blockade of mTORC1 prevent striato-nigral neurons activation in levodopa-induced dyskinesia

(2016) Alberto Brugnoli et al.   NEUROBIOLOGY OF DISEASE

RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum

(2016) N. Shahani et al.   Science Signaling

RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum

(2016) N. Shahani et al.   Science Signaling

Glial activation is associated with l-DOPA induced dyskinesia and blocked by a nitric oxide synthase inhibitor in a rat model of Parkinson's disease

(2015) Mariza Bortolanza et al.   NEUROBIOLOGY OF DISEASE

Loss of glutamic acid decarboxylase (Gad67) in striatal neurons expressing the Drdr1a dopamine receptor prevents l-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned mice

(2015) K. Zhang et al.   NEUROSCIENCE

Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease

(2014) W. M. Pryor et al.   Science Signaling

Dysregulated RasGRP1 Responds to Cytokine Receptor Input in T Cell Leukemogenesis

(2013) C. Hartzell et al.   Science Signaling

Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells

(2013) Robert L. Kortum et al.   TRENDS IN IMMUNOLOGY

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

(2013) Jeffrey S Iwig et al.   eLife

Orientation and Cellular Distribution of Membrane-bound Catechol-O-methyltransferase in Cortical Neurons

(2011) Jingshan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutive abnormal expression of RasGRP-1 isoforms and low expression of PARP-1 in patients with systemic lupus erythematosus

(2011) MJ Rapoport et al.   LUPUS

Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA–induced dyskinesia

(2011) Srinivasa Subramaniam et al.   NATURE NEUROSCIENCE

Impact of the lesion procedure on the profiles of motor impairment and molecular responsiveness to L-DOPA in the 6-hydroxydopamine mouse model of Parkinson's disease

(2011) Veronica Francardo et al.   NEUROBIOLOGY OF DISEASE

Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex

(2011) Mahomi Kuroiwa et al.   PSYCHOPHARMACOLOGY

Inhibition of phosphodiesterases rescues striatal long-term depression and reduces levodopa-induced dyskinesia

(2010) Barbara Picconi et al.   BRAIN

Striatal inhibition of PKA prevents levodopa-induced behavioural and molecular changes in the hemiparkinsonian rat

(2010) Manon Lebel et al.   NEUROBIOLOGY OF DISEASE

Inhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with L-dopa-induced dyskinesia

(2010) S. Fasano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Inactivation of Dopamine D1 but Not D2 Receptors Inhibits L-DOPA–Induced Dyskinesia and Histone Activation

(2009) Sanja Darmopil et al.   BIOLOGICAL PSYCHIATRY

Dysregulation of CalDAG-GEFI and CalDAG-GEFII predicts the severity of motor side-effects induced by anti-parkinsonian therapy

(2009) Jill R. Crittenden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Striatal Akt/GSK3 signaling pathway in the development of L-Dopa-induced dyskinesias in MPTP monkeys

(2009) Marc Morissette et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA-Induced Dyskinesia

(2009) E. Santini et al.   Science Signaling

Amino acid regulation of TOR complex 1

(2008) Joseph Avruch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM