Isoforskolin, an adenylyl cyclase activator, attenuates cigarette smoke-induced COPD in rats

The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation

(2020) Guowei Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent Advances in the Management of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

(2020) Stacey-Ann Whittaker Brown et al.   MEDICAL CLINICS OF NORTH AMERICA

Isoforskolin and forskolin attenuate lipopolysaccharide-induced inflammation through TLR4/MyD88/NF-κB cascades in human mononuclear leukocytes

(2019) Xiaohua Du et al.   PHYTOTHERAPY RESEARCH

The Th17/Treg Cytokine Imbalance in Chronic Obstructive Pulmonary Disease Exacerbation in an Animal Model of Cigarette Smoke Exposure and Lipopolysaccharide Challenge Association

(2019) Daniela A. B. Cervilha et al.   Scientific Reports

Phosphodiesterases as therapeutic targets for respiratory diseases

(2019) Haoxiao Zuo et al.   PHARMACOLOGY & THERAPEUTICS

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor

(2019) Jenna L Jewell et al.   eLife

GOATOOLS: A Python library for Gene Ontology analyses

(2018) D. V. Klopfenstein et al.   Scientific Reports

Roles of Myeloid and Lymphoid Cells in the Pathogenesis of Chronic Obstructive Pulmonary Disease

(2018) Ling Ni et al.   Frontiers in Immunology

PubChem 2019 update: improved access to chemical data

(2018) Sunghwan Kim et al.   NUCLEIC ACIDS RESEARCH

Chronic obstructive pulmonary disease

(2017) Klaus F Rabe et al.   LANCET

cAMP Signaling Compartmentation: Adenylyl Cyclases as Anchors of Dynamic Signaling Complexes

(2017) Timothy B. Johnstone et al.   MOLECULAR PHARMACOLOGY

International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases

(2017) Carmen W. Dessauer et al.   PHARMACOLOGICAL REVIEWS

Adenylyl cyclase signalling complexes – Pharmacological challenges and opportunities

(2017) Michelle L. Halls et al.   PHARMACOLOGY & THERAPEUTICS

Suppression of Th17-polarized airway inflammation by rapamycin

(2017) Oana Joean et al.   Scientific Reports

Experimental animal models for COPD: a methodological review

(2017) Vahideh Ghorani et al.   Tobacco Induced Diseases

Lung tissue proteomics identifies elevated transglutaminase 2 levels in stable chronic obstructive pulmonary disease

(2016) Steffen Ohlmeier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Novel relaxant effects of RPL554 on guinea pig tracheal smooth muscle contractility

(2016) R Venkatasamy et al.   BRITISH JOURNAL OF PHARMACOLOGY

The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic obstructive pulmonary disease in a mouse model

(2016) A G Jarnicki et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal models of COPD: What do they tell us?

(2016) Bernadette Jones et al.   RESPIROLOGY

Roflumilast: a review of its use in the treatment of COPD

(2016) Jadwiga Wedzicha et al.   International Journal of Chronic Obstructive Pulmonary Disease

Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells – Role of Anchored Protein Kinase A Signaling Units

(2016) Vanessa L. Wehbi et al.   Frontiers in Immunology

The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases

(2016) Verena Katharina Raker et al.   Frontiers in Immunology

A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product

(2015) Blaine Phillips et al.   FOOD AND CHEMICAL TOXICOLOGY

Dual PDE3/4 and PDE4 Inhibitors: Novel Treatments For COPD and Other Inflammatory Airway Diseases

(2014) Katharine H. Abbott-Banner et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

KEGG-PATH: Kyoto encyclopedia of genes and genomes-based pathway analysis using a path analysis model

(2014) Junli Du et al.   Molecular BioSystems

Advances in targeting cyclic nucleotide phosphodiesterases

(2014) Donald H. Maurice et al.   NATURE REVIEWS DRUG DISCOVERY

Immunopathogenesis of chronic obstructive pulmonary disease

(2013) Rebecca A. Holloway et al.   CURRENT OPINION IN PULMONARY MEDICINE

Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials

(2013) Lui G Franciosi et al.   Lancet Respiratory Medicine

Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease

(2011) Klaus F. Rabe   BRITISH JOURNAL OF PHARMACOLOGY

Novel cAMP signalling paradigms: therapeutic implications for airway disease

(2011) Charlotte K Billington et al.   BRITISH JOURNAL OF PHARMACOLOGY

cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity

(2011) Jianling Xie et al.   CELLULAR SIGNALLING

Isoforskolin pretreatment attenuates lipopolysaccharide-induced acute lung injury in animal models

(2011) Weimin Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases

(2011) Chen Xie et al.   NUCLEIC ACIDS RESEARCH

A low-polynomial algorithm for assembling clusters of orthologous groups from intergenomic symmetric best matches

(2010) David M. Kristensen et al.   BIOINFORMATICS

Cyclic AMP-mediated immune regulation — Overview of mechanisms of action in T cells

(2010) Randi Mosenden et al.   CELLULAR SIGNALLING

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

(2010) D. Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

(2010) Armin Hatzelmann et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Adenylyl cyclases as innovative therapeutic goals

(2009) Barbara Pavan et al.   DRUG DISCOVERY TODAY

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Capturing adenylyl cyclases as potential drug targets

(2009) Sandra Pierre et al.   NATURE REVIEWS DRUG DISCOVERY

Activation and Inhibition of Adenylyl Cyclase Isoforms by Forskolin Analogs

(2008) C. Pinto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS